Imperial College London
Alternate

ProfessorPraveenAnand

Faculty of Medicine, Department of Brain Sciences

Professor
 
 
 
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Contact

 

+44 (0)20 3313 3319p.anand

 
 
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Location

 

Area A Grd FloorUnknownHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Banati:2001,
author = {Banati, RB and Cagnin, A and Brooks, DJ and Gunn, RN and Myers, R and Jones, T and Birch, R and Anand, P},
journal = {Neuroreport},
pages = {3439--3442},
title = {Long-term trans-synaptic glial responses in the human thalamus after peripheral nerve injury},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11733686},
volume = {12},
year = {2001}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Limb denervation leads to reorganization of the representational zones of the somatosensory cortex. Using [11C](R)-PK11195, a sensitive in vivo marker of glial cell activation, and PET, we provide first evidence that limb denervation induces a trans-synaptic increase in [11C](R)-PK11195 binding in the human thalamus but not somatosensory cortex: these brain structures appeared morphologically normal on magnetic resonance imaging (MRI). The increased thalamic signal was detectable many years after nerve injury, indicating persistent reorganization of the thalamus. This glial activation, beyond the first-order projection area of the injured neurons, may reflect continually altered afferent activity. Our findings support the view that long-term rearrangement of cortical representational maps is significantly determined within the thalamus.
AU  - Banati,RB
AU  - Cagnin,A
AU  - Brooks,DJ
AU  - Gunn,RN
AU  - Myers,R
AU  - Jones,T
AU  - Birch,R
AU  - Anand,P
EP  - 3442
PY  - 2001///
SN  - 0959-4965
SP  - 3439
TI  - Long-term trans-synaptic glial responses in the human thalamus after peripheral nerve injury
T2  - Neuroreport
UR  - http://www.ncbi.nlm.nih.gov/pubmed/11733686
VL  - 12
ER  -
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