Imperial College London
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DrPedroFerreira

Faculty of Medicine, National Heart & Lung Institute

Honorary Research Fellow
 
 
 
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Contact

 

p.f.ferreira05

 
 
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Location

 

Sydney StreetRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Alemany:2023:10.1002/mrm.29737,
author = {Alemany, I and Rose, JN and Ferreira, PF and Pennell, DJ and Nielles-Vallespin, S and Scott, AD and Doorly, DJ},
doi = {10.1002/mrm.29737},
journal = {Magnetic Resonance in Medicine},
pages = {1641--1656},
title = {Realistic numerical simulations of diffusion tensor cardiovascular magnetic resonance: the effects of perfusion and membrane permeability},
url = {http://dx.doi.org/10.1002/mrm.29737},
volume = {90},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - PurposeTo study the sensitivity of diffusion tensor cardiovascular magnetic resonance (DT-CMR) to microvascular perfusion and changes in cell permeability.MethodsMonte Carlo (MC) random walk simulations in the myocardium have been performed to simulate self-diffusion of water molecules in histology-based media with varying extracellular volume fraction (ECV) and permeable membranes. The effect of microvascular perfusion on simulations of the DT-CMR signal has been incorporated by adding the contribution of particles traveling through an anisotropic capillary network to the diffusion signal. The simulations have been performed considering three pulse sequences with clinical gradient strengths: monopolar stimulated echo acquisition mode (STEAM), monopolar pulsed-gradient spin echo (PGSE), and second-order motion-compensated spin echo (MCSE).ResultsReducing ECV intensifies the diffusion restriction and incorporating membrane permeability reduces the anisotropy of the diffusion tensor. Widening the intercapillary velocity distribution results in increased measured diffusion along the cardiomyocytes long axis when the capillary networks are anisotropic. Perfusion amplifies the mean diffusivity for STEAM while the opposite is observed for short diffusion encoding time sequences (PGSE and MCSE).ConclusionThe effect of perfusion on the measured diffusion tensor is reduced using an increased reference b-value. Our results pave the way for characterization of the response of DT-CMR to microstructural changes underlying cardiac pathology and highlight the higher sensitivity of STEAM to permeability and microvascular circulation due to its longer diffusion encoding time.
AU  - Alemany,I
AU  - Rose,JN
AU  - Ferreira,PF
AU  - Pennell,DJ
AU  - Nielles-Vallespin,S
AU  - Scott,AD
AU  - Doorly,DJ
DO  - 10.1002/mrm.29737
EP  - 1656
PY  - 2023///
SN  - 0740-3194
SP  - 1641
TI  - Realistic numerical simulations of diffusion tensor cardiovascular magnetic resonance: the effects of perfusion and membrane permeability
T2  - Magnetic Resonance in Medicine
UR  - http://dx.doi.org/10.1002/mrm.29737
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:001023247800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://onlinelibrary.wiley.com/doi/full/10.1002/mrm.29737
UR  - http://hdl.handle.net/10044/1/107408
VL  - 90
ER  -
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