Imperial College London
Alternate

ProfessorPaulLangford

Faculty of Medicine, Department of Infectious Disease

Professor of Paediatric Infectious Diseases
 
 
 
//

Contact

 

+44 (0)20 7594 3359p.langford Website

 
 
//

Location

 

236Wright Fleming WingSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@inbook{Hamilton:2010:10.1002/9780470665497.ch11,
author = {Hamilton, S and Levin, M and Kroll, JS and Langford, PR},
booktitle = {Mass Spectrometry for Microbial Proteomics},
doi = {10.1002/9780470665497.ch11},
pages = {223--253},
title = {Microbial Disease Biomarkers Using ProteinChip Arrays},
url = {http://dx.doi.org/10.1002/9780470665497.ch11},
year = {2010}
}
Download

RIS format (EndNote, RefMan)

TY  - CHAP
AB  - The last few years has seen a rapid increase in the use of surface enhanced laser desorption ionisation-time of flight (SELDI, SELDI-TOF) mass spectrometry, at the core of which are ProteinChip arrays, to search for biomarkers of infectious disease. Reasons include the greater reproducibility of current technology (instrument and ProteinChip arrays), the availability of increasingly powerful analytical tools and the appreciation of confounding variables (e.g. sample preparation and study design). Biomarkers have been sought for diagnosis of infection, disease progression, prediction of those at high risk from other disease as the result of infection (e.g. cancer) and to increase understanding of infectious disease processes. SELDI has been used for biomarker discovery in humans and animals as a result of infection by bacteria, viruses and parasites. The molecular identification of the discriminatory peptides/proteins allows the development or utilisation of cheaper simpler tests such as ELISAs. In some instances, SELDI has been used to measure biomarkers for infectious disease where conventional tests are unavailable or of insufficient sensitivity and specificity. It is likely that there will be increased use of SELDI, particularly if it is combined with parallel developments in sample preparation, allowing the detection of less abundant and potentially more informative peptides/proteins. © 2010 John Wiley & Sons, Ltd.
AU  - Hamilton,S
AU  - Levin,M
AU  - Kroll,JS
AU  - Langford,PR
DO  - 10.1002/9780470665497.ch11
EP  - 253
PY  - 2010///
SN  - 9780470681992
SP  - 223
TI  - Microbial Disease Biomarkers Using ProteinChip Arrays
T1  - Mass Spectrometry for Microbial Proteomics
UR  - http://dx.doi.org/10.1002/9780470665497.ch11
ER  -
Download