Imperial College London
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Peter Openshaw - Professor of Experimental Medicine

Faculty of Medicine, National Heart & Lung Institute

Proconsul, Professor of Experimental Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3854p.openshaw Website CV

 
 
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Assistant

 

Ms Gale Lewis +44 (0)20 7594 0944

 
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Location

 

353Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Costigan:2024:10.1016/j.mucimm.2023.11.005,
author = {Costigan, D and Fenn, J and Yen, S and Ilott, N and Bullers, S and Hale, J and Greenhalf, W and Conibear, E and Koycheva, A and Madon, K and Jahan, I and Huang, M and Badhan, A and Parker, E and Rosadas, C and Jones, K and McClure, M and Tedder, R and Taylor, G and Baillie, KJ and Semple, MG and Openshaw, PJM and Pearson, C and Johnson, J and INSTINCT, Study Group and ISARIC4C, investigators and Lalvani, A and Thornton, EE},
doi = {10.1016/j.mucimm.2023.11.005},
journal = {Mucosal Immunology},
pages = {111--123},
title = {A pro-inflammatory gut mucosal cytokine response is associated with mild COVID-19 disease and superior induction of serum antibodies},
url = {http://dx.doi.org/10.1016/j.mucimm.2023.11.005},
volume = {17},
year = {2024}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The relationship between gastrointestinal tract infection, the host immune response, and the clinical outcome of disease is not well understood in COVID-19. We sought to understand the effect of intestinal immune responses to SARS-CoV-2 on patient outcomes including the magnitude of systemic antibody induction. Combining two prospective cohort studies, International Severe Acute Respiratory and emerging Infections Consortium Comprehensive Clinical Characterisations Collaboration (ISARIC4C) and Integrated Network for Surveillance, Trials and Investigations into COVID-19 Transmission (INSTINCT), we acquired samples from 88 COVID-19 cases representing the full spectrum of disease severity and analysed viral RNA and host gut cytokine responses in the context of clinical and virological outcome measures. There was no correlation between the upper respiratory tract and faecal viral loads. Using hierarchical clustering, we identified a group of fecal cytokines including Interleukin-17A, Granulocyte macrophage colony-stimulating factor, Tumor necrosis factorα, Interleukin-23, and S100A8, that were transiently elevated in mild cases and also correlated with the magnitude of systemic anti-Spike-receptor-binding domain antibody induction. Receiver operating characteristic curve analysis showed that expression of these gut cytokines at study enrolment in hospitalised COVID-19 cases was associated negatively with overall clinical severity implicating a protective role in COVID-19. This suggests that a productive intestinal immune response may be beneficial in the response to a respiratory pathogen and a biomarker of a successful barrier response.
AU  - Costigan,D
AU  - Fenn,J
AU  - Yen,S
AU  - Ilott,N
AU  - Bullers,S
AU  - Hale,J
AU  - Greenhalf,W
AU  - Conibear,E
AU  - Koycheva,A
AU  - Madon,K
AU  - Jahan,I
AU  - Huang,M
AU  - Badhan,A
AU  - Parker,E
AU  - Rosadas,C
AU  - Jones,K
AU  - McClure,M
AU  - Tedder,R
AU  - Taylor,G
AU  - Baillie,KJ
AU  - Semple,MG
AU  - Openshaw,PJM
AU  - Pearson,C
AU  - Johnson,J
AU  - INSTINCT,Study Group
AU  - ISARIC4C,investigators
AU  - Lalvani,A
AU  - Thornton,EE
DO  - 10.1016/j.mucimm.2023.11.005
EP  - 123
PY  - 2024///
SN  - 1933-0219
SP  - 111
TI  - A pro-inflammatory gut mucosal cytokine response is associated with mild COVID-19 disease and superior induction of serum antibodies
T2  - Mucosal Immunology
UR  - http://dx.doi.org/10.1016/j.mucimm.2023.11.005
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37995912
UR  - http://hdl.handle.net/10044/1/108742
VL  - 17
ER  -
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