Imperial College London

ProfessorRobertWilkinson

Faculty of MedicineDepartment of Infectious Disease

Professor in Infectious Diseases
 
 
 
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Contact

 

r.j.wilkinson Website

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

525 results found

Dodd LE, Wilkinson RJ, 2013, Diagnosis of paediatric tuberculosis: the culture conundrum, LANCET INFECTIOUS DISEASES, Vol: 13, Pages: 3-4, ISSN: 1473-3099

Journal article

O'Garra A, Redford PS, McNab FW, Bloom CI, Wilkinson RJ, Berry MPRet al., 2013, The Immune Response in Tuberculosis, ANNUAL REVIEW OF IMMUNOLOGY, VOL 31, Vol: 31, Pages: 475-527, ISSN: 0732-0582

Journal article

Bloom CI, Graham CM, Berry MP, Rozakeas F, Redford PS, Wang Y, Xu Z, Wilkinson KA, Wilkinson RJ, Kendrick Y, Devouassoux G, Ferry T, Miyara M, Bouvry D, Dominique V, Gorochov G, Blankenship D, Saadatian M, Vanhems P, Beynon H, Vancheeswaran R, Wickremasinghe M, Chaussabel D, Banchereau J, Pascual V, Ho LP, Lipman M, O'Garra Aet al., 2013, Correction: Transcriptional Blood Signatures Distinguish Pulmonary Tuberculosis, Pulmonary Sarcoidosis, Pneumonias and Lung Cancers., PLoS One, Vol: 8

[This corrects the article on p. e70630 in vol. 8.].

Journal article

Oni T, Tsekela R, Kwaza B, Manjezi L, Bangani N, Wilkinson KA, Coetzee D, Wilkinson RJet al., 2012, A Recent HIV Diagnosis Is Associated with Non-Completion of Isoniazid Preventive Therapy in an HIV-Infected Cohort in Cape Town, PLOS ONE, Vol: 7, ISSN: 1932-6203

Journal article

Gideon HP, Wilkinson KA, Rustad TR, Oni T, Guio H, Sherman DR, Vordermeier HM, Robertson BD, Young DB, Wilkinson RJet al., 2012, Bioinformatic and Empirical Analysis of Novel Hypoxia-Inducible Targets of the Human Antituberculosis T Cell Response, JOURNAL OF IMMUNOLOGY, Vol: 189, Pages: 5867-5876, ISSN: 0022-1767

Journal article

Rangaka MX, Wilkinson RJ, Glynn JR, Boulle A, van Cutsem G, Goliath R, Mathee S, Maartens Get al., 2012, Effect of Antiretroviral Therapy on the Diagnostic Accuracy of Symptom Screening for Intensified Tuberculosis Case Finding in a South African HIV Clinic, CLINICAL INFECTIOUS DISEASES, Vol: 55, Pages: 1698-1706, ISSN: 1058-4838

Journal article

Skolimowska KH, Rangaka MX, Meintjes G, Pepper DJ, Seldon R, Matthews K, Wilkinson RJ, Wilkinson KAet al., 2012, Altered Ratio of IFN-γ/IL-10 in Patients with Drug Resistant <i>Mycobacterium tuberculosis</i> and HIV-Tuberculosis Immune Reconstitution Inflammatory Syndrome, PLOS ONE, Vol: 7, ISSN: 1932-6203

Journal article

Oni T, Gideon HP, Bangani N, Tsekela R, Seldon R, Wood K, Wilkinson KA, Goliath RT, Ottenhoff THM, Wilkinson RJet al., 2012, Smoking, BCG and Employment and the Risk of Tuberculosis Infection in HIV-Infected Persons in South Africa, PLOS ONE, Vol: 7, ISSN: 1932-6203

Journal article

Bloom CI, Graham CM, Berry MPR, Wilkinson KA, Oni T, Rozakeas F, Xu Z, Rossello-Urgell J, Chaussabel D, Banchereau J, Pascual V, Lipman M, Wilkinson RJ, O'Garra Aet al., 2012, Detectable Changes in The Blood Transcriptome Are Present after Two Weeks of Antituberculosis Therapy, PLOS ONE, Vol: 7, ISSN: 1932-6203

Journal article

Conesa-Botella A, Meintjes G, Coussens AK, van der Plas H, Goliath R, Schutz C, Moreno-Reyes R, Mehta M, Martineau AR, Wilkinson RJ, Colebunders R, Wilkinson KAet al., 2012, Corticosteroid Therapy, Vitamin D Status, and Inflammatory Cytokine Profile in the HIV-Tuberculosis Immune Reconstitution Inflammatory Syndrome, CLINICAL INFECTIOUS DISEASES, Vol: 55, Pages: 1004-1011, ISSN: 1058-4838

Journal article

Rangaka MX, Boulle A, Wilkinson RJ, van Cutsem G, Goemaere E, Goliath R, Titus R, Mathee S, Maartens Get al., 2012, Randomized controlled trial of isoniazid preventive therapy in HIV-infected persons on antiretroviral therapy, JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, Vol: 15, Pages: 49-50

Journal article

Coussens AK, Wilkinson RJ, Hanifa Y, Nikolayevskyy V, Elkington PT, Islam K, Timms PM, Venton TR, Bothamley GH, Packe GE, Darmalingam M, Davidson RN, Milburn HJ, Baker LV, Barker RD, Mein CA, Bhaw-Rosun L, Nuamah R, Young DB, Drobniewski FA, Griffiths CJ, Martineau ARet al., 2012, Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 109, Pages: 15449-15454, ISSN: 0027-8424

Journal article

Klassen K, Martineau AR, Wilkinson RJ, Cooke G, Courtney AP, Hickson Met al., 2012, The Effect of Tenofovir on Vitamin D Metabolism in HIV-Infected Adults Is Dependent on Sex and Ethnicity, PLOS ONE, Vol: 7, ISSN: 1932-6203

Journal article

Ntsekhe M, Matthews K, Wolske J, Badri M, Wilkinson KA, Wilkinson RJ, Sturrock ED, Mayosi BMet al., 2012, Scientific letter: Ac-SDKP (N-acetyl-seryl-aspartyl-lysyl-proline) and Galectin-3 levels in tuberculous pericardial effusion: implications for pathogenesis and prevention of pericardial constriction, HEART, Vol: 98, Pages: 1326-1328, ISSN: 1355-6037

Journal article

Sarkar R, Lenders L, Wilkinson KA, Wilkinson RJ, Nicol MPet al., 2012, Modern Lineages of <i>Mycobacterium tuberculosis</i> Exhibit Lineage-Specific Patterns of Growth and Cytokine Induction in Human Monocyte-Derived Macrophages, PLOS ONE, Vol: 7, ISSN: 1932-6203

Journal article

Meintjes G, Skolimowska KH, Wilkinson KA, Matthews K, Tadokera R, Conesa-Botella A, Seldon R, Rangaka MX, Rebe K, Pepper DJ, Morroni C, Colebunders R, Maartens G, Wilkinson RJet al., 2012, Corticosteroid-modulated Immune Activation in the Tuberculosis Immune Reconstitution Inflammatory Syndrome, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 186, Pages: 369-377, ISSN: 1073-449X

Journal article

Vordermeier HM, Hewinson RG, Wilkinson RJ, Wilkinson KA, Gideon HP, Young DB, Sampson SLet al., 2012, Conserved Immune Recognition Hierarchy of Mycobacterial PE/PPE Proteins during Infection in Natural Hosts, Plos One

Journal article

Oni T, Gideon HP, Bangani N, Tsekela R, Seldon R, Wood K, Wilkinson KA, Goliath RT, Ottenhoff THM, Wilkinson RJet al., 2012, Risk Factors Associated with Indeterminate Gamma Interferon Responses in the Assessment of Latent Tuberculosis Infection in a High-Incidence Environment, CLINICAL AND VACCINE IMMUNOLOGY, Vol: 19, Pages: 1243-1247, ISSN: 1556-6811

Journal article

Robertson BD, Altmann D, Barry C, Bishai B, Cole S, Dick T, Duncan K, Dye C, Ehrt S, Esmail H, Flynn J, Hafner R, Handley G, Hanekom W, van Helden P, Kaplan G, Kaufmann SHE, Kim P, Lienhardt C, Mizrahi V, Rubin E, Schnappinger D, Sherman D, Thole J, Vandal O, Walzl G, Warner D, Wilkinson R, Young Det al., 2012, Detection and treatment of subclinical tuberculosis, Tuberculosis, Vol: 92, Pages: 447-452, ISSN: 1873-281X

Reduction of active disease by preventive therapy has the potential to make an important contribution towards the goal of tuberculosis (TB) elimination. This report summarises discussions amongst a Working Group convened to consider areas of research that will be important in optimising the design and delivery of preventative therapies. The Working Group met in Cape Town on 26th February 2012, following presentation of results from the GC11 Grand Challenges in Global Health project to discover drugs for latent TB.

Journal article

Oni T, Wilkinson RJ, 2012, Immunodiagnosis of tuberculosis in HIV-infected adults in settings of high HIV/tuberculosis burden, European Respiratory Disease, Vol: 8, Pages: 148-153, ISSN: 1754-5552

The diagnosis of HIV-associated tuberculosis (TB) is challenging. In the diagnosis of latent TB, the sensitivity ofthe tuberculin skin test is impaired in HIV-infected persons and the test lacks specificity because of cross-reactivity with environmental mycobacteria and Bacille Calmette-Guérin vaccine. The conventional method for diagnosis of active TB is sputum smear microscopy and culture of Mycobacterium tuberculosis. However, the paucibacillary nature of TB disease in HIV infection means microscopy is often negative and diagnosis is reliant on a six-week culture. This highlights the need for new and rapid diagnostic tests. Immunodiagnostics represent a recent advance in TB diagnosis and many studies have been conducted to evaluate their performance. However, few have been conducted in HIV-infected adults, who bear a disproportionate burden of TB disease morbidity and mortality, and fewer still in low-income, high-burden settings. This review is of immunodiagnostic tests in the diagnosis of active and latent TB, with a focus on HIV-infected adults in high-burden settings. © TOUCH BRIEFINGS 2012.

Journal article

Pepper DJ, Marais S, Bhaijee F, Wilkinson RJ, De Azevedo V, Meintjes Get al., 2012, Assessment at Antiretroviral Clinics during TB Treatment Reduces Loss to Follow-Up among HIV-Infected Patients, PLOS ONE, Vol: 7, ISSN: 1932-6203

Journal article

Wilkinson KA, Meintjes G, Seldon R, Goliath R, Wilkinson RJet al., 2012, Immunological characterisation of an unmasking TB-IRIS case, SAMJ SOUTH AFRICAN MEDICAL JOURNAL, Vol: 102, Pages: 512-517, ISSN: 0256-9574

Journal article

Schutz C, Ismail Z, Proxenos CJ, Marais S, Burton R, Kenyon C, Maartens G, Wilkinson RJ, Meintjes Get al., 2012, Burden of antituberculosis and antiretroviral drug-induced liver injury at a secondary hospital in South Africa, SAMJ SOUTH AFRICAN MEDICAL JOURNAL, Vol: 102, Pages: 506-511, ISSN: 0256-9574

Journal article

Walker NF, Clark SO, Oni T, Andreu N, Tezera L, Singh S, Saraiva L, Pedersen B, Kelly DL, Tree JA, D'Armiento JM, Meintjes G, Mauri FA, Williams A, Wilkinson RJ, Friedland JS, Elkington PTet al., 2012, Doxycycline and HIV Infection Suppress Tuberculosis-induced Matrix Metalloproteinases, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 185, Pages: 989-997, ISSN: 1073-449X

Journal article

Esmail H, Barry CE, Wilkinson RJ, 2012, Understanding latent tuberculosis: the key to improved diagnostic and novel treatment strategies, DRUG DISCOVERY TODAY, Vol: 17, Pages: 514-521, ISSN: 1359-6446

Journal article

Wilkinson RJ, 2012, Human Genetic Susceptibility to Tuberculosis: Time for a Bottom-Up Approach?, JOURNAL OF INFECTIOUS DISEASES, Vol: 205, Pages: 525-527, ISSN: 0022-1899

Journal article

Lowe DM, Redford PS, Wilkinson RJ, O'Garra A, Martineau ARet al., 2012, Neutrophils in tuberculosis: friend or foe?, TRENDS IN IMMUNOLOGY, Vol: 33, Pages: 14-25, ISSN: 1471-4906

Journal article

Bond E, Liang F, Sandgren KJ, Smed-Sorensen A, Bergman P, Brighenti S, Adams WC, Betemariam SA, Rangaka MX, Lange C, Wilkinson RJ, Andersson J, Lore Ket al., 2012, Plasmacytoid Dendritic Cells Infiltrate the Skin in Positive Tuberculin Skin Test Indurations, JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol: 132, Pages: 114-123, ISSN: 0022-202X

Journal article

Rangaka MX, Gideon HP, Wilkinson KA, Pai M, Mwansa-Kambafwile J, Maartens G, Glynn JR, Boulle A, Fielding K, Goliath R, Titus R, Mathee S, Wilkinson RJet al., 2012, Interferon release does not add discriminatory value to smear-negative HIV-tuberculosis algorithms, EUROPEAN RESPIRATORY JOURNAL, Vol: 39, Pages: 163-171, ISSN: 0903-1936

Journal article

Rangaka MX, Wilkinson KA, Glynn JR, Ling D, Menzies D, Mwansa-Kambafwile J, Fielding K, Wilkinson RJ, Pai Met al., 2012, Predictive value of interferon-γ release assays for incident active tuberculosis: a systematic review and meta-analysis, LANCET INFECTIOUS DISEASES, Vol: 12, Pages: 45-55, ISSN: 1473-3099

Journal article

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