Publications
525 results found
Dodd LE, Wilkinson RJ, 2013, Diagnosis of paediatric tuberculosis: the culture conundrum, LANCET INFECTIOUS DISEASES, Vol: 13, Pages: 3-4, ISSN: 1473-3099
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- Citations: 10
O'Garra A, Redford PS, McNab FW, et al., 2013, The Immune Response in Tuberculosis, ANNUAL REVIEW OF IMMUNOLOGY, VOL 31, Vol: 31, Pages: 475-527, ISSN: 0732-0582
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- Citations: 861
Bloom CI, Graham CM, Berry MP, et al., 2013, Correction: Transcriptional Blood Signatures Distinguish Pulmonary Tuberculosis, Pulmonary Sarcoidosis, Pneumonias and Lung Cancers., PLoS One, Vol: 8
[This corrects the article on p. e70630 in vol. 8.].
Oni T, Tsekela R, Kwaza B, et al., 2012, A Recent HIV Diagnosis Is Associated with Non-Completion of Isoniazid Preventive Therapy in an HIV-Infected Cohort in Cape Town, PLOS ONE, Vol: 7, ISSN: 1932-6203
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- Citations: 12
Gideon HP, Wilkinson KA, Rustad TR, et al., 2012, Bioinformatic and Empirical Analysis of Novel Hypoxia-Inducible Targets of the Human Antituberculosis T Cell Response, JOURNAL OF IMMUNOLOGY, Vol: 189, Pages: 5867-5876, ISSN: 0022-1767
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- Citations: 22
Rangaka MX, Wilkinson RJ, Glynn JR, et al., 2012, Effect of Antiretroviral Therapy on the Diagnostic Accuracy of Symptom Screening for Intensified Tuberculosis Case Finding in a South African HIV Clinic, CLINICAL INFECTIOUS DISEASES, Vol: 55, Pages: 1698-1706, ISSN: 1058-4838
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- Citations: 44
Skolimowska KH, Rangaka MX, Meintjes G, et al., 2012, Altered Ratio of IFN-γ/IL-10 in Patients with Drug Resistant <i>Mycobacterium tuberculosis</i> and HIV-Tuberculosis Immune Reconstitution Inflammatory Syndrome, PLOS ONE, Vol: 7, ISSN: 1932-6203
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- Citations: 21
Oni T, Gideon HP, Bangani N, et al., 2012, Smoking, BCG and Employment and the Risk of Tuberculosis Infection in HIV-Infected Persons in South Africa, PLOS ONE, Vol: 7, ISSN: 1932-6203
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- Citations: 19
Bloom CI, Graham CM, Berry MPR, et al., 2012, Detectable Changes in The Blood Transcriptome Are Present after Two Weeks of Antituberculosis Therapy, PLOS ONE, Vol: 7, ISSN: 1932-6203
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- Citations: 149
Conesa-Botella A, Meintjes G, Coussens AK, et al., 2012, Corticosteroid Therapy, Vitamin D Status, and Inflammatory Cytokine Profile in the HIV-Tuberculosis Immune Reconstitution Inflammatory Syndrome, CLINICAL INFECTIOUS DISEASES, Vol: 55, Pages: 1004-1011, ISSN: 1058-4838
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- Citations: 59
Rangaka MX, Boulle A, Wilkinson RJ, et al., 2012, Randomized controlled trial of isoniazid preventive therapy in HIV-infected persons on antiretroviral therapy, JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, Vol: 15, Pages: 49-50
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- Citations: 2
Coussens AK, Wilkinson RJ, Hanifa Y, et al., 2012, Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 109, Pages: 15449-15454, ISSN: 0027-8424
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- Citations: 225
Klassen K, Martineau AR, Wilkinson RJ, et al., 2012, The Effect of Tenofovir on Vitamin D Metabolism in HIV-Infected Adults Is Dependent on Sex and Ethnicity, PLOS ONE, Vol: 7, ISSN: 1932-6203
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- Citations: 16
Ntsekhe M, Matthews K, Wolske J, et al., 2012, Scientific letter: Ac-SDKP (N-acetyl-seryl-aspartyl-lysyl-proline) and Galectin-3 levels in tuberculous pericardial effusion: implications for pathogenesis and prevention of pericardial constriction, HEART, Vol: 98, Pages: 1326-1328, ISSN: 1355-6037
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- Citations: 15
Sarkar R, Lenders L, Wilkinson KA, et al., 2012, Modern Lineages of <i>Mycobacterium tuberculosis</i> Exhibit Lineage-Specific Patterns of Growth and Cytokine Induction in Human Monocyte-Derived Macrophages, PLOS ONE, Vol: 7, ISSN: 1932-6203
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- Citations: 52
Meintjes G, Skolimowska KH, Wilkinson KA, et al., 2012, Corticosteroid-modulated Immune Activation in the Tuberculosis Immune Reconstitution Inflammatory Syndrome, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 186, Pages: 369-377, ISSN: 1073-449X
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- Citations: 62
Vordermeier HM, Hewinson RG, Wilkinson RJ, et al., 2012, Conserved Immune Recognition Hierarchy of Mycobacterial PE/PPE Proteins during Infection in Natural Hosts, Plos One
Oni T, Gideon HP, Bangani N, et al., 2012, Risk Factors Associated with Indeterminate Gamma Interferon Responses in the Assessment of Latent Tuberculosis Infection in a High-Incidence Environment, CLINICAL AND VACCINE IMMUNOLOGY, Vol: 19, Pages: 1243-1247, ISSN: 1556-6811
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- Citations: 21
Robertson BD, Altmann D, Barry C, et al., 2012, Detection and treatment of subclinical tuberculosis, Tuberculosis, Vol: 92, Pages: 447-452, ISSN: 1873-281X
Reduction of active disease by preventive therapy has the potential to make an important contribution towards the goal of tuberculosis (TB) elimination. This report summarises discussions amongst a Working Group convened to consider areas of research that will be important in optimising the design and delivery of preventative therapies. The Working Group met in Cape Town on 26th February 2012, following presentation of results from the GC11 Grand Challenges in Global Health project to discover drugs for latent TB.
Oni T, Wilkinson RJ, 2012, Immunodiagnosis of tuberculosis in HIV-infected adults in settings of high HIV/tuberculosis burden, European Respiratory Disease, Vol: 8, Pages: 148-153, ISSN: 1754-5552
The diagnosis of HIV-associated tuberculosis (TB) is challenging. In the diagnosis of latent TB, the sensitivity ofthe tuberculin skin test is impaired in HIV-infected persons and the test lacks specificity because of cross-reactivity with environmental mycobacteria and Bacille Calmette-Guérin vaccine. The conventional method for diagnosis of active TB is sputum smear microscopy and culture of Mycobacterium tuberculosis. However, the paucibacillary nature of TB disease in HIV infection means microscopy is often negative and diagnosis is reliant on a six-week culture. This highlights the need for new and rapid diagnostic tests. Immunodiagnostics represent a recent advance in TB diagnosis and many studies have been conducted to evaluate their performance. However, few have been conducted in HIV-infected adults, who bear a disproportionate burden of TB disease morbidity and mortality, and fewer still in low-income, high-burden settings. This review is of immunodiagnostic tests in the diagnosis of active and latent TB, with a focus on HIV-infected adults in high-burden settings. © TOUCH BRIEFINGS 2012.
Pepper DJ, Marais S, Bhaijee F, et al., 2012, Assessment at Antiretroviral Clinics during TB Treatment Reduces Loss to Follow-Up among HIV-Infected Patients, PLOS ONE, Vol: 7, ISSN: 1932-6203
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- Citations: 8
Wilkinson KA, Meintjes G, Seldon R, et al., 2012, Immunological characterisation of an unmasking TB-IRIS case, SAMJ SOUTH AFRICAN MEDICAL JOURNAL, Vol: 102, Pages: 512-517, ISSN: 0256-9574
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- Citations: 10
Schutz C, Ismail Z, Proxenos CJ, et al., 2012, Burden of antituberculosis and antiretroviral drug-induced liver injury at a secondary hospital in South Africa, SAMJ SOUTH AFRICAN MEDICAL JOURNAL, Vol: 102, Pages: 506-511, ISSN: 0256-9574
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- Citations: 24
Walker NF, Clark SO, Oni T, et al., 2012, Doxycycline and HIV Infection Suppress Tuberculosis-induced Matrix Metalloproteinases, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 185, Pages: 989-997, ISSN: 1073-449X
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- Citations: 103
Esmail H, Barry CE, Wilkinson RJ, 2012, Understanding latent tuberculosis: the key to improved diagnostic and novel treatment strategies, DRUG DISCOVERY TODAY, Vol: 17, Pages: 514-521, ISSN: 1359-6446
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- Citations: 73
Wilkinson RJ, 2012, Human Genetic Susceptibility to Tuberculosis: Time for a Bottom-Up Approach?, JOURNAL OF INFECTIOUS DISEASES, Vol: 205, Pages: 525-527, ISSN: 0022-1899
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- Citations: 10
Lowe DM, Redford PS, Wilkinson RJ, et al., 2012, Neutrophils in tuberculosis: friend or foe?, TRENDS IN IMMUNOLOGY, Vol: 33, Pages: 14-25, ISSN: 1471-4906
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- Citations: 223
Bond E, Liang F, Sandgren KJ, et al., 2012, Plasmacytoid Dendritic Cells Infiltrate the Skin in Positive Tuberculin Skin Test Indurations, JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol: 132, Pages: 114-123, ISSN: 0022-202X
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- Citations: 20
Rangaka MX, Gideon HP, Wilkinson KA, et al., 2012, Interferon release does not add discriminatory value to smear-negative HIV-tuberculosis algorithms, EUROPEAN RESPIRATORY JOURNAL, Vol: 39, Pages: 163-171, ISSN: 0903-1936
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- Citations: 23
Rangaka MX, Wilkinson KA, Glynn JR, et al., 2012, Predictive value of interferon-γ release assays for incident active tuberculosis: a systematic review and meta-analysis, LANCET INFECTIOUS DISEASES, Vol: 12, Pages: 45-55, ISSN: 1473-3099
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- Citations: 385
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