Imperial College London
Professor Robert Wilkinson

ProfessorRobertWilkinson

Faculty of Medicine, Department of Infectious Disease

Professor in Infectious Diseases
 
 
 
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Contact

 

r.j.wilkinson Website

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hussey:2022:10.1016/j.ijid.2022.02.051,
author = {Hussey, H and Davies, M-A and Heekes, A and Williamson, C and Valley-Omar, Z and Hardie, D and Korsman, S and Doolabh, D and Preiser, W and Maponga, T and Iranzadeh, A and Wasserman, S and Boloko, L and Symons, G and Raubenheimer, P and Parker, A and Schrueder, N and Solomon, W and Rousseau, P and Wolter, N and Jassat, W and Cohen, C and Lessells, R and Wilkinson, RJ and Boulle, A and Hsiao, N-Y},
doi = {10.1016/j.ijid.2022.02.051},
journal = {International Journal of Infectious Diseases},
pages = {150--154},
title = {Assessing the clinical severity of the Omicron variant in the Western Cape Province, South Africa, using the diagnostic PCR proxy marker of RdRp target delay to distinguish between Omicron and Delta infections - a survival analysis},
url = {http://dx.doi.org/10.1016/j.ijid.2022.02.051},
volume = {118},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: The extent to which the reduced risk of severe disease seen with SARS-CoV-2 Omicron is due to a decrease in variant virulence, or higher levels of population immunity, is currently not clear. METHODS: RdRp target delay (RTD) in the Seegene AllplexTM 2019-nCoV PCR assay is a proxy marker for the Delta variant. The absence of this proxy marker in the transition period was used to identify suspected Omicron infections. Cox regression was performed for the outcome of hospital admission in those who tested positive for SARS-CoV-2 on the Seegene AllplexTM assay from 1 November to 14 December 2021 in the Western Cape Province, South Africa, public sector. Vaccination status and prior diagnosed infection, were adjusted for. RESULTS: 150 cases with RTD and 1486 cases without RTD were included. Cases without RTD had a lower hazard of admission (adjusted Hazard Ratio [aHR] of 0.56, 95%CI 0.34-0.91). Complete vaccination was protective of admission with an aHR of 0.45 (95%CI 0.26-0.77). CONCLUSION: Omicron has resulted in a lower risk of hospital admission, compared to contemporaneous Delta infection, when using the proxy marker of RTD. Under-ascertainment of reinfections with an immune escape variant remains a challenge to accurately assessing variant virulence.
AU  - Hussey,H
AU  - Davies,M-A
AU  - Heekes,A
AU  - Williamson,C
AU  - Valley-Omar,Z
AU  - Hardie,D
AU  - Korsman,S
AU  - Doolabh,D
AU  - Preiser,W
AU  - Maponga,T
AU  - Iranzadeh,A
AU  - Wasserman,S
AU  - Boloko,L
AU  - Symons,G
AU  - Raubenheimer,P
AU  - Parker,A
AU  - Schrueder,N
AU  - Solomon,W
AU  - Rousseau,P
AU  - Wolter,N
AU  - Jassat,W
AU  - Cohen,C
AU  - Lessells,R
AU  - Wilkinson,RJ
AU  - Boulle,A
AU  - Hsiao,N-Y
DO  - 10.1016/j.ijid.2022.02.051
EP  - 154
PY  - 2022///
SN  - 1201-9712
SP  - 150
TI  - Assessing the clinical severity of the Omicron variant in the Western Cape Province, South Africa, using the diagnostic PCR proxy marker of RdRp target delay to distinguish between Omicron and Delta infections - a survival analysis
T2  - International Journal of Infectious Diseases
UR  - http://dx.doi.org/10.1016/j.ijid.2022.02.051
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35235826
UR  - http://hdl.handle.net/10044/1/95846
VL  - 118
ER  -
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