Imperial College London
Professor Robert Wilkinson

ProfessorRobertWilkinson

Faculty of Medicine, Department of Infectious Disease

Professor in Infectious Diseases
 
 
 
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Contact

 

r.j.wilkinson Website

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rangaka:2014:10.1016/S0140-6736(14)60162-8,
author = {Rangaka, MX and Wilkinson, RJ and Boulle, A and Glynn, JR and Fielding, K and van, Cutsem G and Wilkinson, KA and Goliath, R and Mathee, S and Goemaere, E and Maartens, G},
doi = {10.1016/S0140-6736(14)60162-8},
journal = {The Lancet},
pages = {682--690},
title = {Isoniazid plus antiretroviral therapy to prevent tuberculosis: a randomised double-blind, placebo-controlled trial},
url = {http://dx.doi.org/10.1016/S0140-6736(14)60162-8},
volume = {384},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundAntiretroviral therapy reduces the risk of tuberculosis, but tuberculosis is more common in people with HIV than in people without HIV. We aimed to assess the effect of isoniazid preventive therapy on the risk of tuberculosis in people infected with HIV-1 concurrently receiving antiretroviral therapy.MethodsFor this pragmatic randomised double-blind, placebo-controlled trial in Khayelitsha, South Africa, we randomly assigned (1:1) patients to receive either isoniazid preventive therapy or a placebo for 12 months (could be completed during 15 months). Randomisation was done with random number generator software. Participants, physicians, and pharmacy staff were masked to group assignment. The primary endpoint was time to development of incident tuberculosis (definite, probable, or possible). We excluded tuberculosis at screening by sputum culture. We did a modified intention-to-treat analysis and excluded all patients randomly assigned to groups who withdrew before receiving study drug or whose baseline sputum culture results suggested prevalent tuberculosis. This study is registered with ClinicalTrials.gov, number NCT00463086.Findings1329 participants were randomly assigned to receive isoniazid preventive therapy (n=662) or placebo (n=667) between Jan 31, 2008, and Sept 31, 2011, and contributed 3227 person-years of follow-up to the analysis. We recorded 95 incident cases of tuberculosis; 37 were in the isoniazid preventive therapy group (2·3 per 100 person-years, 95% CI 1·6–3·1), and 58 in the placebo group (3·6 per 100 person-years, 2·8–4·7; hazard ratio [HR] 0·63, 95% CI 0·41–0·94). Study drug was discontinued because of grade 3 or 4 raised alanine transaminase concentrations in 19 of 662 individuals in the isoniazid preventive therapy group and ten of the 667 individuals in the placebo group (risk ratio 1·9, 95% CI 0·90–4·09). We noted no evidenc
AU  - Rangaka,MX
AU  - Wilkinson,RJ
AU  - Boulle,A
AU  - Glynn,JR
AU  - Fielding,K
AU  - van,Cutsem G
AU  - Wilkinson,KA
AU  - Goliath,R
AU  - Mathee,S
AU  - Goemaere,E
AU  - Maartens,G
DO  - 10.1016/S0140-6736(14)60162-8
EP  - 690
PY  - 2014///
SN  - 0140-6736
SP  - 682
TI  - Isoniazid plus antiretroviral therapy to prevent tuberculosis: a randomised double-blind, placebo-controlled trial
T2  - The Lancet
UR  - http://dx.doi.org/10.1016/S0140-6736(14)60162-8
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000341359100026&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
VL  - 384
ER  -
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