Imperial College London
Professor Robert Wilkinson

ProfessorRobertWilkinson

Faculty of Medicine, Department of Infectious Disease

Professor in Infectious Diseases
 
 
 
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Contact

 

r.j.wilkinson Website

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Coussens:2014:2014/903680,
author = {Coussens, AK and Martineau, AR and Wilkinson, RJ},
doi = {2014/903680},
journal = {Scientifica (Cairo)},
pages = {903680--903680},
title = {Anti-Inflammatory and Antimicrobial Actions of Vitamin D in Combating TB/HIV.},
url = {http://dx.doi.org/10.1155/2014/903680},
volume = {2014},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - TUBERCULOSIS (TB) DISEASE ACTIVATION IS NOW BELIEVED TO ARISE DUE TO A LACK OF INFLAMMATORY HOMEOSTATIC CONTROL AT EITHER END OF THE SPECTRUM OF INFLAMMATION: either due to immunosuppression (decreased antimicrobial activity) or due to immune activation (excess/aberrant inflammation). Vitamin D metabolites can increase antimicrobial activity in innate immune cells, which, in the context of HIV-1 coinfection, have insufficient T cell-mediated help to combat Mycobacterium tuberculosis (MTB) infection. Moreover, maintaining vitamin D sufficiency prior to MTB infection enhances the innate antimicrobial response to T cell-mediated interferon-γ. Conversely, vitamin D can act to inhibit expression and secretion of a broad range of inflammatory mediators and matrix degrading enzymes driving immunopathology during active TB and antiretroviral- (ARV-) mediated immune reconstitution inflammatory syndrome (IRIS). Adjunct vitamin D therapy during treatment of active TB may therefore reduce lung pathology and TB morbidity, accelerate resolution of cavitation and thereby decrease the chance of transmission, improve lung function following therapy, prevent relapse, and prevent IRIS in those initiating ARVs. Future clinical trials of vitamin D for TB prevention and treatment must be designed to detect the most appropriate primary endpoint, which in some cases should be anti-inflammatory and not antimicrobial.
AU  - Coussens,AK
AU  - Martineau,AR
AU  - Wilkinson,RJ
DO  - 2014/903680
EP  - 903680
PY  - 2014///
SN  - 2090-908X
SP  - 903680
TI  - Anti-Inflammatory and Antimicrobial Actions of Vitamin D in Combating TB/HIV.
T2  - Scientifica (Cairo)
UR  - http://dx.doi.org/10.1155/2014/903680
UR  - https://www.ncbi.nlm.nih.gov/pubmed/25101194
UR  - http://hdl.handle.net/10044/1/18514
VL  - 2014
ER  -
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