Imperial College London
Professor Robert Wilkinson

ProfessorRobertWilkinson

Faculty of Medicine, Department of Infectious Disease

Professor in Infectious Diseases
 
 
 
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Contact

 

r.j.wilkinson Website

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Coussens:2015:10.1073/pnas.1500909112,
author = {Coussens, AK and Naude, CE and Goliath, R and Chaplin, G and Wilkinson, RJ and Jablonski, NG},
doi = {10.1073/pnas.1500909112},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
pages = {8052--8057},
title = {High-dose vitamin D3 reduces deficiency caused by low UVB exposure and limits HIV-1 replication in urban Southern Africans.},
url = {http://dx.doi.org/10.1073/pnas.1500909112},
volume = {112},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cape Town, South Africa, has a seasonal pattern of UVB radiation and a predominantly dark-skinned urban population who suffer high HIV-1 prevalence. This coexistent environmental and phenotypic scenario puts residents at risk for vitamin D deficiency, which may potentiate HIV-1 disease progression. We conducted a longitudinal study in two ethnically distinct groups of healthy young adults in Cape Town, supplemented with vitamin D3 in winter, to determine whether vitamin D status modifies the response to HIV-1 infection and to identify the major determinants of vitamin D status (UVB exposure, diet, pigmentation, and genetics). Vitamin D deficiency was observed in the majority of subjects in winter and in a proportion of individuals in summer, was highly correlated with UVB exposure, and was associated with greater HIV-1 replication in peripheral blood cells. High-dosage oral vitamin D3 supplementation attenuated HIV-1 replication, increased circulating leukocytes, and reversed winter-associated anemia. Vitamin D3 therefore presents as a low-cost supplementation to improve HIV-associated immunity.
AU  - Coussens,AK
AU  - Naude,CE
AU  - Goliath,R
AU  - Chaplin,G
AU  - Wilkinson,RJ
AU  - Jablonski,NG
DO  - 10.1073/pnas.1500909112
EP  - 8057
PY  - 2015///
SN  - 1091-6490
SP  - 8052
TI  - High-dose vitamin D3 reduces deficiency caused by low UVB exposure and limits HIV-1 replication in urban Southern Africans.
T2  - Proceedings of the National Academy of Sciences of the United States of America
UR  - http://dx.doi.org/10.1073/pnas.1500909112
UR  - http://hdl.handle.net/10044/1/25022
VL  - 112
ER  -
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