Imperial College London
Professor Robert Wilkinson

ProfessorRobertWilkinson

Faculty of Medicine, Department of Infectious Disease

Professor in Infectious Diseases
 
 
 
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Contact

 

r.j.wilkinson Website

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Getahun:2015:10.1183/13993003.01245-2015,
author = {Getahun, H and Matteelli, A and Abubakar, I and Aziz, MA and Baddeley, A and Barreira, D and Den, Boon S and Borroto, Gutierrez SM and Bruchfeld, J and Burhan, E and Cavalcante, S and Cedillos, R and Chaisson, R and Chee, CB and Chesire, L and Corbett, E and Dara, M and Denholm, J and de, Vries G and Falzon, D and Ford, N and Gale-Rowe, M and Gilpin, C and Girardi, E and Go, UY and Govindasamy, D and Grant, AD and Grzemska, M and Harris, R and Horsburgh, CR and Ismayilov, A and Jaramillo, E and Kik, S and Kranzer, K and Lienhardt, C and LoBue, P and Lönnroth, K and Marks, G and Menzies, D and Migliori, GB and Mosca, D and Mukadi, YD and Mwinga, A and Nelson, L and Nishikiori, N and Oordt-Speets, A and Rangaka, MX and Reis, A and Rotz, L and Sandgren, A and Sañé, Schepisi M and Schünemann, HJ and Sharma, SK and Sotgiu, G and Stagg, HR and Sterling, TR and Tayeb, T and Uplekar, M and van, der Werf MJ and Vandevelde, W and van, Kessel F and Van't, Hoog A and Varma, JK and Vezhnina, N and },
doi = {10.1183/13993003.01245-2015},
journal = {European Respiratory Journal},
title = {Management of latent Mycobacterium tuberculosis infection: WHO guidelines for low tuberculosis burden countries.},
url = {http://dx.doi.org/10.1183/13993003.01245-2015},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Latent tuberculosis infection (LTBI) is characterised by the presence of immune responses to previously acquired Mycobacterium tuberculosis infection without clinical evidence of active tuberculosis (TB). Here we report evidence-based guidelines from the World Health Organization for a public health approach to the management of LTBI in high risk individuals in countries with high or middle upper income and TB incidence of <100 per 100000 per year. The guidelines strongly recommend systematic testing and treatment of LTBI in people living with HIV, adult and child contacts of pulmonary TB cases, patients initiating anti-tumour necrosis factor treatment, patients receiving dialysis, patients preparing for organ or haematological transplantation, and patients with silicosis. In prisoners, healthcare workers, immigrants from high TB burden countries, homeless persons and illicit drug users, systematic testing and treatment of LTBI is conditionally recommended, according to TB epidemiology and resource availability. Either commercial interferon-gamma release assays or Mantoux tuberculin skin testing could be used to test for LTBI. Chest radiography should be performed before LTBI treatment to rule out active TB disease. Recommended treatment regimens for LTBI include: 6 or 9month isoniazid; 12week rifapentine plus isoniazid; 3-4month isoniazid plus rifampicin; or 3-4month rifampicin alone.
AU  - Getahun,H
AU  - Matteelli,A
AU  - Abubakar,I
AU  - Aziz,MA
AU  - Baddeley,A
AU  - Barreira,D
AU  - Den,Boon S
AU  - Borroto,Gutierrez SM
AU  - Bruchfeld,J
AU  - Burhan,E
AU  - Cavalcante,S
AU  - Cedillos,R
AU  - Chaisson,R
AU  - Chee,CB
AU  - Chesire,L
AU  - Corbett,E
AU  - Dara,M
AU  - Denholm,J
AU  - de,Vries G
AU  - Falzon,D
AU  - Ford,N
AU  - Gale-Rowe,M
AU  - Gilpin,C
AU  - Girardi,E
AU  - Go,UY
AU  - Govindasamy,D
AU  - Grant,AD
AU  - Grzemska,M
AU  - Harris,R
AU  - Horsburgh,CR
AU  - Ismayilov,A
AU  - Jaramillo,E
AU  - Kik,S
AU  - Kranzer,K
AU  - Lienhardt,C
AU  - LoBue,P
AU  - Lönnroth,K
AU  - Marks,G
AU  - Menzies,D
AU  - Migliori,GB
AU  - Mosca,D
AU  - Mukadi,YD
AU  - Mwinga,A
AU  - Nelson,L
AU  - Nishikiori,N
AU  - Oordt-Speets,A
AU  - Rangaka,MX
AU  - Reis,A
AU  - Rotz,L
AU  - Sandgren,A
AU  - Sañé,Schepisi M
AU  - Schünemann,HJ
AU  - Sharma,SK
AU  - Sotgiu,G
AU  - Stagg,HR
AU  - Sterling,TR
AU  - Tayeb,T
AU  - Uplekar,M
AU  - van,der Werf MJ
AU  - Vandevelde,W
AU  - van,Kessel F
AU  - Van't,Hoog A
AU  - Varma,JK
AU  - Vezhnina,N
AU  - Voniatis,C
AU  - Vonk,Noordegraaf-Schouten M
AU  - Weil,D
AU  - Weyer,K
AU  - Wilkinson,RJ
AU  - Yoshiyama,T
AU  - Zellweger,JP
AU  - Raviglione,M
DO  - 10.1183/13993003.01245-2015
PY  - 2015///
SN  - 1399-3003
TI  - Management of latent Mycobacterium tuberculosis infection: WHO guidelines for low tuberculosis burden countries.
T2  - European Respiratory Journal
UR  - http://dx.doi.org/10.1183/13993003.01245-2015
ER  -
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