Imperial College London
Professor Robert Wilkinson

ProfessorRobertWilkinson

Faculty of Medicine, Department of Infectious Disease

Professor in Infectious Diseases
 
 
 
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Contact

 

r.j.wilkinson Website

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Norval:2016:10.3390/ijerph13101019,
author = {Norval, M and Coussens, AK and Wilkinson, RJ and Bornmann, L and Lucas, RM and Wright, CV},
doi = {10.3390/ijerph13101019},
journal = {International Journal of Environmental Research and Public Health},
title = {Vitamin D Status and Its Consequences for Health in South Africa},
url = {http://dx.doi.org/10.3390/ijerph13101019},
volume = {13},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In this review, reports were retrieved in which vitamin D status, as assessed by serum25-hydroxyvitamin D [25(OH)D] levels, was measured in South African population groups withvaried skin colours and ethnicities. Healthy children and adults were generally vitamin D-sufficient[25(OH)D level >50 nmol/L] but the majority of those aged above 65 years were deficient. A majorrole for exposure to solar ultraviolet radiation (UVR) in determining 25(OH)D levels was apparent,with the dietary contribution being minor. Limited data exist regarding the impact of recentchanges in lifestyles on vitamin D status, such as urbanisation. With regard to disease susceptibility,11 of 22 relevant publications indicated association between low 25(OH)D levels and disease, withdeficiency most notably found in individuals with tuberculosis and HIV-1. Information on therelationship between vitamin D receptor variants and ethnicity, disease or treatment response in theSouth African population groups demonstrated complex interactions between genetics, epigeneticsand the environment. Whether vitamin D plays an important role in protection against the rangeof diseases that currently constitute a large burden on the health services in South Africa requiresfurther investigation. Only then can accurate advice be given about personal sun exposure or dietaryvitamin D supplementation.
AU  - Norval,M
AU  - Coussens,AK
AU  - Wilkinson,RJ
AU  - Bornmann,L
AU  - Lucas,RM
AU  - Wright,CV
DO  - 10.3390/ijerph13101019
PY  - 2016///
SN  - 1660-4601
TI  - Vitamin D Status and Its Consequences for Health in South Africa
T2  - International Journal of Environmental Research and Public Health
UR  - http://dx.doi.org/10.3390/ijerph13101019
UR  - http://hdl.handle.net/10044/1/41743
VL  - 13
ER  -
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