Publications
184 results found
Erro R, Picillo M, Vitale C, et al., 2016, Clinical clusters and dopaminergic dysfunction in de-novo Parkinson disease, Parkinsonism & Related Disorders, Vol: 28, Pages: 137-140, ISSN: 1353-8020
BACKGROUND: The heterogeneity of PD suggests the existence of different subtypes. While some motor clusters have been consistently identified, little is known about non-motor PD subtypes and motor-non-motor interplay. Research in this regard has produced somewhat contradictory results, which might be biased by the inclusion of treated patients. PATIENTS AND METHODS: We performed a non-hierarchical cluster analysis using both motor and non-motor data on 398 newly diagnosed untreated PD patients enrolled in the Parkinson's Progressive Marker Initiative (PPMI) study. We further evaluated whether dopaminergic dysfunction, as measured by (123)[I]-FP-CIT SPECT scan, could explain, at least partially, the observed difference between the clusters. RESULTS: Three clusters were identified. Group 1 was characterized by the lowest motor and non-motor burden, whereas group 2 and 3 had similar motor disability, but different non-motor involvement, especially with regards to apathy and hallucinations. (123)[I]-FP-CIT binding values paralleled motor disability burden among the 3 clusters, but further multivariate analyses also revealed a negative correlation with depression. DISCUSSION: Our results confirm the motor as well as non-motor heterogeneity of PD, suggesting the existence of 3 different subtypes. Dopaminergic dysfunction only marginally explains the non-motor variability of PD. Identification of such clusters can have important implications for generating novel pathophysiological hypotheses and therapeutic strategies.
Moccia M, Palladino R, Falco A, et al., 2016, Google Trends: new evidence for seasonality of multiple sclerosis, Journal of Neurology Neurosurgery and Psychiatry, Vol: 87, Pages: 1028-1029, ISSN: 1468-330X
Moccia M, Palladino R, Lanzillo R, et al., 2016, Predictors of Long-Term Interferon Discontinuation in Newly Diagnosed Relapsing Multiple Sclerosis, 68th Annual Meeting of the American-Academy-of-Neurology (AAN), Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0028-3878
Moccia M, Palladino R, Lanzillo R, et al., 2016, Predictors of Long-Term Interferon Discontinuation in Newly Diagnosed Relapsing Multiple Sclerosis, 68th Annual Meeting of the American-Academy-of-Neurology (AAN), Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0028-3878
Picillo M, Palladino R, Moccia M, et al., 2016, Gender and non motor fluctuations in Parkinson's disease: A prospective study, Parkinsonism & Related Disorders, Vol: 27, Pages: 89-92, ISSN: 1353-8020
Palladino R, Tayu Lee J, Ashworth M, et al., 2016, Associations between multimorbidity, healthcare utilisation and health status: evidence from 16 European countries, Age and Ageing, Vol: 45, Pages: 431-435, ISSN: 1468-2834
Background: with ageing populations and increasing exposure to risk factors for chronic diseases, the prevalence of chronic disease multimorbidity is rising globally. There is little evidence on the determinants of multimorbidity and its impact on healthcare utilisation and health status in Europe.Methods: we used cross-sectional data from the Survey of Health, Ageing and Retirement in Europe (SHARE) in 2011–12, which included nationally representative samples of persons aged 50 and older from 16 European nations. Negative binomial and logistic regression models were used to assess the association between number of chronic diseases and healthcare utilisation, self-perceived health, depression and reduction of functional capacity.Results: overall, 37.3% of participants reported multimorbidity; the lowest prevalence was in Switzerland (24.7%), the highest in Hungary (51.0%). The likelihood of having multimorbidity increased substantially with age. Number of chronic conditions was associated with greater healthcare utilisation in both primary (regression coefficient for medical doctor visits = 0.29, 95% CI = 0.27–0.30) and secondary setting (adjusted odds ratio (AOR) for having any hospitalisation in the last year = 1.49, 95% CI = 1.42–1.55) in all countries analysed. Number of chronic diseases was associated with fair/poor health status (AOR 2.13, 95% CI = 2.03–2.24), being depressed (AOR 1.48, 95% CI = 1.42–1.54) and reduced functional capacity (AOR 2.12, 95% CI = 2.02–2.22).Conclusion: multimorbidity is associated with greater healthcare utilisation, worse self-reported health status, depression and reduced functional capacity in European countries. European health systems should prioritise improving the management of patients with multimorbidity to improve their health status and increase healthcare efficiency.
Hone T, Palladino R, Filippidis FT, 2016, Association of searching for health-related information online with self-rated health in the European Union., European Journal of Public Health, Vol: 26, Pages: 748-753, ISSN: 1464-360X
BACKGROUND: The Internet is widely accessed for health information, but poor quality information may lead to health-worsening behaviours (e.g. non-compliance). Little is known about the health of individuals who use the Internet for health information. METHODS: Using the Flash Eurobarometer survey 404, European Union (EU) citizens aged ≥15 (n = 26 566) were asked about Internet utilisation for health information ('general' or 'disease-specific'), the sources used, self-rated health, and socioeconomic variables. Multivariable logistic regression was employed to assess the likelihood of bad self-rated health and accessing different health information sources (social networks, official website, online newspaper, dedicated websites, search engines). RESULTS: Those searching for general information were less likely to report bad health [odds ratios (OR) = 0.80; 95% confidence intervals (CI): 0.70-0.92], whilst those searching for disease-specific information were more likely (OR = 1.22; 95% CI: 1.07-1.38). Higher education and frequent doctor visits were associated with use of official websites and dedicated apps for health. Variation between EU member states in the proportion of people who had searched for general or disease-specific information online was high. CONCLUSIONS: Searching for general health information may be more conducive to better health, as it is easier to understand, and those accessing it may already be or looking to lead healthier lives. Disease-specific information may be harder to understand and assimilate into appropriate care worsening self-rated health. It may also be accessed if health services fail to meet individuals' needs, and health status is currently poor. Ensuring individuals' access to quality health services and health information will be key to addressing inequalities in health.
Moccia M, Erro R, Picillo M, et al., 2016, A Four-Year Longitudinal Study on Restless Legs Syndrome in Parkinson Disease, SLEEP, Vol: 39, Pages: 405-412
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- Citations: 56
Moccia M, Palladino R, Russo C, et al., 2015, How many injections did you miss last month? A simple question to predict interferon β-1a adherence in multiple sclerosis, EXPERT OPINION ON DRUG DELIVERY, Vol: 12, Pages: 1829-1835, ISSN: 1742-5247
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- Citations: 25
Moccia M, Lanzillo R, Palladino R, et al., 2015, Cognitive impairment at diagnosis predicts 10-year multiple sclerosis progression, Multiple Sclerosis Journal, Vol: 22, Pages: 659-667, ISSN: 1477-0970
Background: Cognitive impairment occurs from the early phases of multiple sclerosis (MS), and more frequently affects secondary progressive (SP) subjects than relapsing–remitting (RR).Objective: To investigate relationships between cognitive dysfunctions in newly diagnosed RRMS, and long-term MS-related outcomes.Methods: The present 10-year retrospective longitudinal study included 155 RRMS subjects, tested with the Rao Brief Repeatable Battery at MS diagnosis. The reaching of Expanded Disability Status Scale (EDSS) 4.0, and the SP conversion were recorded.Results: 67 subjects (43.2%) reached EDSS 4.0, and 34 subjects (21.9%) converted to SP during a follow-up period of 10.0±1.8 years. Subjects with cognitive impairment at diagnosis had a rate of reaching EDSS 4.0 more than three times greater (p<0.001; HR=3.183), and a rate of SP conversion more than two times greater, as compared to cognitively preserved subjects (p=0.008; HR=2.535). In particular, better scores in the Selective Reminding Test-Delayed Recall and in the Symbol Digit Modalities Test at baseline were associated with lower SP conversion rates during the follow-up period (p=0.018; HR=0.835; and p=0.001; HR=0.941, respectively).Conclusion: Cognitive impairment, with particular involvement of processing speed and memory, predicts disability progression and SP conversion in newly diagnosed RRMS, highlighting the importance of cognitive assessment from the beginning of MS.
Moccia M, Quarantelli M, Lanzillo R, et al., 2015, Grey/white matter ratio at diagnosis, and the risk of 10-year multiple sclerosis progression, 31st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), Publisher: SAGE PUBLICATIONS LTD, Pages: 181-181, ISSN: 1352-4585
Moccia M, Palladino R, Russo C, et al., 2015, How many injections did you miss last month? A simple question to predict Interferon β-1a adherence in multiple sclerosis, 31st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), Publisher: SAGE PUBLICATIONS LTD, Pages: 694-695, ISSN: 1352-4585
Moccia M, Lanzillo R, Palladino R, et al., 2015, The Framingham cardiovascular risk score in multiple sclerosis, EUROPEAN JOURNAL OF NEUROLOGY, Vol: 22, Pages: 1176-1183, ISSN: 1351-5101
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- Citations: 49
Palladino R, Moccia M, De Pascale T, et al., 2015, Season of birth and Parkinson's disease: possible relationship?, NEUROLOGICAL SCIENCES, Vol: 36, Pages: 1457-1462, ISSN: 1590-1874
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- Citations: 5
Erro R, Rocchi L, Antelmi E, et al., 2015, High frequency repetitive sensory stimulation improves temporal discrimination in healthy subjects, CLINICAL NEUROPHYSIOLOGY, Vol: 127, Pages: 817-820, ISSN: 1388-2457
ObjectiveHigh frequency electrical stimulation of an area of skin on a finger improves two-point spatial discrimination in the stimulated area, likely depending on plastic changes in the somatosensory cortex. However, it is unknown whether improvement also applies to temporal discrimination.MethodsTwelve young and ten elderly volunteers underwent the stimulation protocol onto the palmar skin of the right index finger. Somatosensory temporal discrimination threshold (STDT) was evaluated before and immediately after stimulation as well as 2.5 h and 24 h later.ResultsThere was a significant reduction in somatosensory temporal threshold only on the stimulated finger. The effect was reversible, with STDT returning to the baseline values within 24 h, and was smaller in the elderly than in the young participants.ConclusionsHigh frequency stimulation of the skin focally improves temporal discrimination in the area of stimulation. Given previous suggestions that the perceptual effects rely on plastic changes in the somatosensory cortex, our results are consistent with the idea that the timing of sensory stimuli is, at least partially, encoded in the primary somatosensory cortex.SignificanceSuch a protocol could potentially be used as a therapeutic intervention to ameliorate physiological decline in the elderly or in other disorders of sensorimotor integration.
Moccia M, Picillo M, Erro R, et al., 2015, Increased bilirubin levels in <i>de novo</i> Parkinson's disease, EUROPEAN JOURNAL OF NEUROLOGY, Vol: 22, Pages: 954-959, ISSN: 1351-5101
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- Citations: 25
Criscuolo C, Lanzillo R, Cianflone A, et al., 2015, Endothelin-1 serum levels are increased in patients with multiple sclerosis, 1st Congress of the European-Academy-of-Neurology, Publisher: WILEY, Pages: 299-299, ISSN: 1351-5101
Moccia M, Lanzillo R, Palladino R, et al., 2015, Cognitive impairment predicts disability and progression in newly-diagnosed relapsing-remitting multiple sclerosis, 1st Congress of the European-Academy-of-Neurology, Publisher: WILEY, Pages: 87-87, ISSN: 1351-5101
Moccia M, Lanzillo R, Palladino R, et al., 2015, The Framingham cardiovascular risk score in multiple sclerosis, 1st Congress of the European-Academy-of-Neurology, Publisher: WILEY, Pages: 202-202, ISSN: 1351-5101
Laverty AA, Palladino R, Lee JT, et al., 2015, Associations between active travel and weight, blood pressure and diabetes in six middle income countries: a cross-sectional study in older adults, International Journal of Behavioral Nutrition and Physical Activity, Vol: 12, ISSN: 1479-5868
Moccia M, Lanzillo R, Palladino R, et al., 2015, Uric acid: a potential biomarker of multiple sclerosis and of its disability, CLINICAL CHEMISTRY AND LABORATORY MEDICINE, Vol: 53, Pages: 753-759, ISSN: 1434-6621
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- Citations: 30
Moccia M, Lanzillo R, Costabile T, et al., 2015, Uric acid in relapsing-remitting multiple sclerosis: a 2-year longitudinal study, JOURNAL OF NEUROLOGY, Vol: 262, Pages: 961-967, ISSN: 0340-5354
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- Citations: 27
Moccia M, Erro R, Picillo M, et al., 2015, Quitting smoking: An early non-motor feature of Parkinson's disease?, PARKINSONISM & RELATED DISORDERS, Vol: 21, Pages: 216-220, ISSN: 1353-8020
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- Citations: 17
Moccia M, Pappata S, Erro R, et al., 2015, Uric acid relates to dopamine transporter availability in Parkinson's disease, ACTA NEUROLOGICA SCANDINAVICA, Vol: 131, Pages: 127-131, ISSN: 0001-6314
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- Citations: 26
Moccia M, Picillo M, Erro R, et al., 2015, Presence and progression of non-motor symptoms in relation to uric acid in <i>de novo</i> Parkinson's disease, EUROPEAN JOURNAL OF NEUROLOGY, Vol: 22, Pages: 93-98, ISSN: 1351-5101
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- Citations: 47
Moccia M, Mollenhauer B, Erro R, et al., 2015, Non-Motor Correlates of Smoking Habits in de Novo Parkinson's Disease, JOURNAL OF PARKINSONS DISEASE, Vol: 5, Pages: 913-924, ISSN: 1877-7171
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- Citations: 7
Moccia M, Lanzillo R, Palladino R, et al., 2014, Uric acid levels are reduced in multiple sclerosis, Joint ACTRIMS-ECTRIMS Meeting, Publisher: SAGE PUBLICATIONS LTD, Pages: 186-186, ISSN: 1352-4585
Laverty AA, Palladino R, Lee JT, et al., 2014, ASSOCIATIONS BETWEEN ACTIVE TRAVEL AND WEIGHT AND HYPERTENSION IN SIX LOWER AND MIDDLE INCOME COUNTRIES: A CROSS-SECTIONAL STUDY, JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, Vol: 68, Pages: A76-A76, ISSN: 0143-005X
Moccia M, Picillo M, Erro R, et al., 2014, How does smoking affect olfaction in Parkinson's disease?, JOURNAL OF THE NEUROLOGICAL SCIENCES, Vol: 340, Pages: 215-217, ISSN: 0022-510X
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- Citations: 10
Costantino C, Mazzucco W, Azzolini E, et al., 2014, Influenza vaccination coverage among medical residents An Italian multicenter survey, HUMAN VACCINES & IMMUNOTHERAPEUTICS, Vol: 10, Pages: 1204-1210, ISSN: 2164-5515
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- Citations: 29
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