Imperial College London
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DrRahaPazoki

Faculty of Medicine, School of Public Health

Honorary Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 1174r.pazoki

 
 
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Location

 

VC7Praed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pazoki:2010:10.1007/s12170-010-0128-2,
author = {Pazoki, R and Wilde, AAM and Bezzina, CR},
doi = {10.1007/s12170-010-0128-2},
journal = {Curr Cardiovasc Risk Rep},
pages = {454--460},
title = {Genetic Basis of Ventricular Arrhythmias.},
url = {http://dx.doi.org/10.1007/s12170-010-0128-2},
volume = {4},
year = {2010}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Sudden cardiac death (SCD) is a leading cause of total and cardiovascular mortality, and ventricular fibrillation is the underlying arrhythmia in the majority of cases. In the young, where the incidence of SCD is low, a great proportion of SCDs occur in the context of inherited disorders such as cardiomyopathy or primary electrical disease, where a monogenic hereditary component is a strong determinant of risk. Marked advancement has been made over the past 15 years in the understanding of the genetic basis of the primary electrical disorders, and this has had an enormous impact on the management of these patients. At older ages, the great majority of SCDs occur in the context of acute myocardial ischemia and infarction. Although epidemiologic studies have shown that heritable factors also determine risk in these cases, inheritance is likely complex and multifactorial, and progress in understanding the genetic and molecular mechanisms that determine susceptibility to these arrhythmias, affecting a greater proportion of the population, has been very limited. We review the most recent insights gained into the genetic basis of both the monogenic and the more complex ventricular arrhythmias.
AU  - Pazoki,R
AU  - Wilde,AAM
AU  - Bezzina,CR
DO  - 10.1007/s12170-010-0128-2
EP  - 460
PY  - 2010///
SN  - 1932-9520
SP  - 454
TI  - Genetic Basis of Ventricular Arrhythmias.
T2  - Curr Cardiovasc Risk Rep
UR  - http://dx.doi.org/10.1007/s12170-010-0128-2
UR  - https://www.ncbi.nlm.nih.gov/pubmed/20936162
VL  - 4
ER  -
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