Imperial College London
Portrait Picture

Dr Ricardo Petraco

Faculty of Medicine, National Heart & Lung Institute

Honorary Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3386r.petraco

 
 
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Location

 

Block B Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Petraco:2018:10.1136/openhrt-2017-000663,
author = {Petraco, Da Cunha R and Dehbi, H-M and Howard, J and Shun-Shin, MJ and Sen, S and Nijjer, S and Mayet, J and Davies, JE and Francis, DF},
doi = {10.1136/openhrt-2017-000663},
journal = {Open Heart},
title = {Effects of disease severity distribution on the performance of quantitative diagnostic methods and proposal of a novel ‘V-plot’ methodology to display accuracy values},
url = {http://dx.doi.org/10.1136/openhrt-2017-000663},
volume = {5},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background Diagnostic accuracy is widely accepted by researchers and clinicians as an optimal expression of a test’s performance. The aim of this study was to evaluate the effects of disease severity distribution on values of diagnostic accuracy as well as propose a sample-independent methodology to calculate and display accuracy of diagnostic tests.Methods and findings We evaluated the diagnostic relationship between two hypothetical methods to measure serum cholesterol (Cholrapid and Cholgold) by generating samples with statistical software and (1) keeping the numerical relationship between methods unchanged and (2) changing the distribution of cholesterol values. Metrics of categorical agreement were calculated (accuracy, sensitivity and specificity). Finally, a novel methodology to display and calculate accuracy values was presented (the V-plot of accuracies).Conclusion No single value of diagnostic accuracy can be used to describe the relationship between tests, as accuracy is a metric heavily affected by the underlying sample distribution. Our novel proposed methodology, the V-plot of accuracies, can be used as a sample-independent measure of a test performance against a reference gold standard.
AU  - Petraco,Da Cunha R
AU  - Dehbi,H-M
AU  - Howard,J
AU  - Shun-Shin,MJ
AU  - Sen,S
AU  - Nijjer,S
AU  - Mayet,J
AU  - Davies,JE
AU  - Francis,DF
DO  - 10.1136/openhrt-2017-000663
PY  - 2018///
SN  - 2053-3624
TI  - Effects of disease severity distribution on the performance of quantitative diagnostic methods and proposal of a novel ‘V-plot’ methodology to display accuracy values
T2  - Open Heart
UR  - http://dx.doi.org/10.1136/openhrt-2017-000663
UR  - http://hdl.handle.net/10044/1/54345
VL  - 5
ER  -
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