Imperial College London
Alternate

Professor Richard Reynolds, BSc AKC PhD

Faculty of Medicine, Department of Brain Sciences

Professor of Cellular Neurobiology
 
 
 
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Contact

 

+44 (0)20 7594 6668r.reynolds

 
 
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Location

 

E414Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cencioni:2024:10.1186/s12974-024-03077-9,
author = {Cencioni, MT and Magliozzi, R and Palmisano, I and Suwan, K and Mensi, A and Fuentes-Font, L and Villar, LM and Fernández-Velasco, JI and Migallón, NV and Costa-Frossard, L and Monreal, E and Ali, R and Romozzi, M and Mazarakis, N and Reynolds, R and Nicholas, R and Muraro, PA},
doi = {10.1186/s12974-024-03077-9},
journal = {Journal of Neuroinflammation},
title = {Soluble CD27 is an intrathecal biomarker of T-cell-mediated lesion activity in multiple sclerosis},
url = {http://dx.doi.org/10.1186/s12974-024-03077-9},
volume = {21},
year = {2024}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ObjectiveSoluble CD27 is a promising cerebrospinal fluid inflammatory biomarker in multiple sclerosis. In this study, we investigate relevant immune and neuro-pathological features of soluble CD27 in multiple sclerosis.MethodsProtein levels of soluble CD27 were correlated to inflammatory cell subpopulations and inflammatory cytokines and chemokines detected in cerebrospinal fluid of 137 patients with multiple sclerosis and 47 patients with inflammatory and non-inflammatory neurological disease from three independent cohorts. Production of soluble CD27 was investigated in cell cultures of activated T and B cells and CD27-knockout T cells. In a study including matched cerebrospinal fluid and post-mortem brain tissues of patients with multiple sclerosis and control cases, levels of soluble CD27 were correlated with perivascular and meningeal infiltrates and with neuropathological features.ResultsWe demonstrate that soluble CD27 favours the differentiation of interferon-γ-producing T cells and is released through a secretory mechanism activated by TCR engagement and regulated by neutral sphingomyelinase. We also show that the levels of soluble CD27 correlate with the representation of inflammatory T cell subsets in the CSF of patients with relapsing-remitting multiple sclerosis and with the magnitude of perivascular and meningeal CD27 + CD4 + and CD8 + T cell infiltrates in post-mortem central nervous system tissue, defining a subgroup of patients with extensive active inflammatory lesions.InterpretationOur results demonstrate that soluble CD27 is a biomarker of disease activity, potentially informative for personalized treatment and monitoring of treatment outcomes.
AU  - Cencioni,MT
AU  - Magliozzi,R
AU  - Palmisano,I
AU  - Suwan,K
AU  - Mensi,A
AU  - Fuentes-Font,L
AU  - Villar,LM
AU  - Fernández-Velasco,JI
AU  - Migallón,NV
AU  - Costa-Frossard,L
AU  - Monreal,E
AU  - Ali,R
AU  - Romozzi,M
AU  - Mazarakis,N
AU  - Reynolds,R
AU  - Nicholas,R
AU  - Muraro,PA
DO  - 10.1186/s12974-024-03077-9
PY  - 2024///
SN  - 1742-2094
TI  - Soluble CD27 is an intrathecal biomarker of T-cell-mediated lesion activity in multiple sclerosis
T2  - Journal of Neuroinflammation
UR  - http://dx.doi.org/10.1186/s12974-024-03077-9
UR  - https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-024-03077-9
UR  - http://hdl.handle.net/10044/1/111031
VL  - 21
ER  -
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