Imperial College London
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ProfessorRoxySenior

Faculty of Medicine, National Heart & Lung Institute

Professor of Clinical Cardiology
 
 
 
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Contact

 

+44 (0)20 7351 8635r.senior

 
 
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Location

 

Chelsea WingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Moceri:2016:ehjci/jew277,
author = {Moceri, P and Bouvier, P and Baudouy, D and Dimopoulos, K and Cerboni, P and Wort, SJ and Doyen, D and Schouver, ED and Gibelin, P and Senior, R and Gatzoulis, MA and Ferrari, E and Li, W},
doi = {ehjci/jew277},
journal = {Eur Heart J Cardiovasc Imaging},
title = {Cardiac remodelling amongst adults with various aetiologies of pulmonary arterial hypertension including Eisenmenger syndrome-implications on survival and the role of right ventricular transverse strain.},
url = {http://dx.doi.org/10.1093/ehjci/jew277},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - AIMS: Survival in pulmonary arterial hypertension (PAH) and Eisenmenger syndrome (ES) relates to right ventricular (RV) function. Little is known about differences of ventricular function between ES patients and those suffering from other PAH aetiologies. In this study, we compared global ventricular function assessed by speckle-tracking in adult patients with ES, other PAH aetiologies, or healthy controls; and assessed the relationship between ventricular function and survival. METHODS AND RESULTS: We performed a prospective cohort study recruiting 83 adult PAH patients (43 ES and 40 other PAH aetiologies patients) and 37 controls between March 2011 and June 2015. Patients with complex congenital heart disease were excluded. Fifty-three patients (63.9%) were in NYHA functional class ≥III at baseline and 60 (72.3%) were on advanced therapies. Mean RV peak longitudinal strain was -16.3 ± 7% in ES, lower compared with healthy controls (P < 0.001) but similar to other PAH aetiologies (P = 0.6). Mean RV peak transverse strain was +26.1 ± 17% in ES, lower than in controls (P < 0.001) but higher than in other PAH aetiologies (P < 0.001). No difference was observed between ES and other PAH in LV circumferential and longitudinal strain. Over a median follow-up of 22.6 months (3.3-32.2), 22 (26.5%) patients died all from cardio-pulmonary causes. ES and RV peak transverse strain were independent predictors of survival. RV peak transverse strain ≤22% identified patients with a 14-fold increased risk of death. CONCLUSION: Right ventricular remodelling differs between adults with ES and other PAH aetiologies. ES and increased RV free wall transverse strain are associated with better survival.
AU  - Moceri,P
AU  - Bouvier,P
AU  - Baudouy,D
AU  - Dimopoulos,K
AU  - Cerboni,P
AU  - Wort,SJ
AU  - Doyen,D
AU  - Schouver,ED
AU  - Gibelin,P
AU  - Senior,R
AU  - Gatzoulis,MA
AU  - Ferrari,E
AU  - Li,W
DO  - ehjci/jew277
PY  - 2016///
TI  - Cardiac remodelling amongst adults with various aetiologies of pulmonary arterial hypertension including Eisenmenger syndrome-implications on survival and the role of right ventricular transverse strain.
T2  - Eur Heart J Cardiovasc Imaging
UR  - http://dx.doi.org/10.1093/ehjci/jew277
UR  - http://www.ncbi.nlm.nih.gov/pubmed/28011668
ER  -
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