Imperial College London
Alternate

ProfessorRobinShattock

Faculty of Medicine, Department of Infectious Disease

Chair in Mucosal Infection and Immunity
 
 
 
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Contact

 

+44 (0)20 7594 5206r.shattock

 
 
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Location

 

453Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Margolis:2006:10.1038/nrmicro1387,
author = {Margolis, L and Shattock, R},
doi = {10.1038/nrmicro1387},
journal = {Nat Rev Microbiol},
pages = {312--317},
title = {Selective transmission of CCR5-utilizing HIV-1: the 'gatekeeper' problem resolved?},
url = {http://dx.doi.org/10.1038/nrmicro1387},
volume = {4},
year = {2006}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Understanding the mechanisms of HIV-1 transmission is crucial for the development of effective preventive microbicides and vaccine strategies, and remains one of the main goals of HIV research. Over the past decade, many studies have focused on trying to identify the 'gatekeeping' mechanism that restricts the transmission of CXCR4-utilizing HIV-1 more efficiently than CCR5-utilizing HIV-1. However, to date, no study has explained the almost perfect negative selection of the former in vivo. Here, we propose that there is no single gatekeeper and that, instead, the selective transmission of R5 HIV-1 depends on the superimposition of multiple imperfect gatekeepers.
AU  - Margolis,L
AU  - Shattock,R
DO  - 10.1038/nrmicro1387
EP  - 317
PY  - 2006///
SN  - 1740-1526
SP  - 312
TI  - Selective transmission of CCR5-utilizing HIV-1: the 'gatekeeper' problem resolved?
T2  - Nat Rev Microbiol
UR  - http://dx.doi.org/10.1038/nrmicro1387
UR  - https://www.ncbi.nlm.nih.gov/pubmed/16541138
VL  - 4
ER  -
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