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@article{Klasse:2008:10.1146/annurev.med.59.061206.112737,
author = {Klasse, PJ and Shattock, R and Moore, JP},
doi = {10.1146/annurev.med.59.061206.112737},
journal = {Annu Rev Med},
pages = {455--471},
title = {Antiretroviral drug-based microbicides to prevent HIV-1 sexual transmission.},
url = {http://dx.doi.org/10.1146/annurev.med.59.061206.112737},
volume = {59},
year = {2008}
}

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TY  - JOUR
AB  - The development of a vaginal (and perhaps a rectal) microbicide would be of major benefit for slowing the global spread of human immunodeficiency virus type 1 (HIV-1). A microbicide is a gel or related device that, when inserted vaginally or rectally, acts to prevent infection of a woman or a man by HIV-1 during sexual intercourse. A practical microbicide must be not only effective, safe, and user-friendly but also economically affordable in the developing world. To date, the performance of microbicide candidates in efficacy trials has been disappointing, but next-generation concepts now in or approaching clinical trials offer improved prospects for efficacy. The most plausible approaches involve topical application of antiretroviral agents with specific activity against HIV-1, compounds similar to drugs used to treat HIV-1 infection. How these inhibitors are applied may also be critical, with sustained-release formulations and vaginal ring delivery systems now becoming a high priority.
AU  - Klasse,PJ
AU  - Shattock,R
AU  - Moore,JP
DO  - 10.1146/annurev.med.59.061206.112737
EP  - 471
PY  - 2008///
SN  - 0066-4219
SP  - 455
TI  - Antiretroviral drug-based microbicides to prevent HIV-1 sexual transmission.
T2  - Annu Rev Med
UR  - http://dx.doi.org/10.1146/annurev.med.59.061206.112737
UR  - https://www.ncbi.nlm.nih.gov/pubmed/17892435
VL  - 59
ER  -

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