Imperial College London
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Dr Sara De Matteis

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

s.de-matteis

 
 
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Location

 

G51Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{De:2019:10.1183/13993003.00186-2019,
author = {De, Matteis S and Jarvis, D and Darnton, A and Hutchings, S and Sadhra, S and Fishwick, D and Rushton, L and Cullinan, P},
doi = {10.1183/13993003.00186-2019},
journal = {European Respiratory Journal},
pages = {1--9},
title = {The occupations at increased risk of chronic obstructive pulmonary disease (COPD): analysis of lifetime job-histories in the population-based UK Biobank Cohort},
url = {http://dx.doi.org/10.1183/13993003.00186-2019},
volume = {54},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Occupational exposures are important, preventable causes of chronic obstructive pulmonary disease (COPD). Identification of COPD high-risk jobs is key to focus preventive strategies, but a definitive job-list is unavailable.We addressed this issue by evaluating the association of lifetime job-histories and lung function data in the population-based UK Biobank cohort, whose unprecedented sample size allowed analyses restricted to never-smokers to rule out the most important confounder, tobacco smoking. COPD was spirometrically-defined as forced expiratory volume in 1s (FEV1)/forced vital capacity (FVC) <lower limit of normal (LLN). Lifetime job-histories were collected via OSCAR, a new validated online-tool that automatically codes jobs into the UK Standard Occupational Classification v.2000. Prevalence ratios for COPD by employment duration in each job compared to lifetime office workers were estimated using robust Poisson regression adjusted for age, sex, centre and smoking. Only associations confirmed among never-smokers and never-asthmatics were considered reliable.From the 116375 participants with complete job-histories, 94551 had acceptable/repeatable spirometry data and smoking information and were included in the analysis. Six occupations showed an increased COPD risk also among never-smokers and never-asthmatics; most of these also with positive exposure-response trends. Interesting new findings included sculptors, gardeners, and warehouse workers.COPD patients, especially never-smokers, should be asked about their job-history for better disease management. Focussed preventive strategies in COPD high-risk jobs are warranted.
AU  - De,Matteis S
AU  - Jarvis,D
AU  - Darnton,A
AU  - Hutchings,S
AU  - Sadhra,S
AU  - Fishwick,D
AU  - Rushton,L
AU  - Cullinan,P
DO  - 10.1183/13993003.00186-2019
EP  - 9
PY  - 2019///
SN  - 0903-1936
SP  - 1
TI  - The occupations at increased risk of chronic obstructive pulmonary disease (COPD): analysis of lifetime job-histories in the population-based UK Biobank Cohort
T2  - European Respiratory Journal
UR  - http://dx.doi.org/10.1183/13993003.00186-2019
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31248951
UR  - https://erj.ersjournals.com/content/54/1/1900186
UR  - http://hdl.handle.net/10044/1/71333
VL  - 54
ER  -
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