Imperial College London
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Emeritus ProfessorStephenFranks

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Emeritus Professor of Reproductive Endocrinology
 
 
 
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Contact

 

+44 (0)20 7594 2109s.franks Website

 
 
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Assistant

 

Miss Kiran Dosanjh +44 (0)20 7594 4217

 
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Location

 

5009Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Polson:1987:10.1111/j.1365-2265.1987.tb00777.x,
author = {Polson, DW and Mason, HD and Franks, S},
doi = {10.1111/j.1365-2265.1987.tb00777.x},
journal = {Clin Endocrinol (Oxf)},
pages = {197--203},
title = {Bromocriptine treatment of women with clomiphene-resistant polycystic ovary syndrome.},
url = {http://dx.doi.org/10.1111/j.1365-2265.1987.tb00777.x},
volume = {26},
year = {1987}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Twenty-three patients with polycystic ovary syndrome and anovulatory infertility have been treated with bromocriptine. All had previously failed to respond to clomiphene. Twenty had normal serum prolactin concentrations and, of these, four (20%) developed regular ovulatory cycles. All three women with moderate hyperprolactinaemia ovulated regularly on bromocriptine so that, overall, seven of 23(30%) responded, which was a significantly higher proportion than that observed during a control period of no treatment. A further eight women ovulated at least once during the study period but these occasional ovulations were no more common during bromocriptine than with either clomiphene or no treatment. No suppression of LH was noted except during the luteal phase of ovulatory cycles and there was no change in the pattern of pulsatile release of LH. Testosterone and androstenedione concentrations remained elevated and unchanged. We conclude that bromocriptine may be expected to induce ovulation in hyperprolactinaemic women with polycystic ovary syndrome but that there is no clear indication for its use in clomiphene-resistant patients with normal serum prolactin concentrations.
AU  - Polson,DW
AU  - Mason,HD
AU  - Franks,S
DO  - 10.1111/j.1365-2265.1987.tb00777.x
EP  - 203
PY  - 1987///
SN  - 0300-0664
SP  - 197
TI  - Bromocriptine treatment of women with clomiphene-resistant polycystic ovary syndrome.
T2  - Clin Endocrinol (Oxf)
UR  - http://dx.doi.org/10.1111/j.1365-2265.1987.tb00777.x
UR  - https://www.ncbi.nlm.nih.gov/pubmed/3117444
VL  - 26
ER  -
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