Summary
Bacterial pathogens cause many diseases in humans and are frequently well controlled by treatment with antibiotics. However, antibiotics are increasingly becoming inefficient. In addition to the well-documented cases of antibiotic resistance, persistence, characterised by relapsing infections following antibiotic treatment, is a major problem. We investigate Salmonella persisters during infection.
After completing my Ph.D. at Universite Paris 5- Necker, Paris, France, in 2006 with Dr Vladimir Pelicic, I joined the CMBI in the Department of Medicine at Imperial College London as a Research Associate in the laboratory of Prof David Holden in 2007. I have been awarded a Junior Research Fellowship by Imperial College London in 2012 and started my own research group as a Senior Research Fellow to study the formation and biology of Salmonella persisters during infection of the host in 2013. I became a senior lecturer of the MRC Centre for Molecular Bacteriology of Infection at Imperial College London and a Lister Research Prize fellow since 2017. I moved my lab to Harvard Medical School in the Department of Microbiology in summer 2019.
www.helainelab.com
Publications
Journals
Grabe GJ, Giorgio RT, Wieczór M, et al., 2024, Molecular stripping underpins derepression of a toxin-antitoxin system., Nat Struct Mol Biol
Ronneau S, Michaux C, Giorgio RT, et al., 2024, Intoxication of antibiotic persisters by host RNS inactivates their efflux machinery during infection., Plos Pathog, Vol:20
Thurston TLM, Helaine S, 2023, Editorial overview: Two to tango: The intricate communications between host and bacteria, Current Opinion in Microbiology, Vol:74, ISSN:1369-5274
Ronneau S, Michaux C, Helaine S, 2023, Decline in nitrosative stress drives antibiotic persister regrowth during infection, Cell Host & Microbe, Vol:31, ISSN:1931-3128, Pages:993-+
Rizvanovic A, Michaux C, Panza M, et al., 2022, The RNA-Binding Protein ProQ Promotes Antibiotic Persistence in Salmonella, Mbio, Vol:13, ISSN:2150-7511