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@article{Castro-Verdes:2020:ehjcr/ytaa470,
author = {Castro-Verdes, M and Gkouma, A and Wort, J and Ridge, C and Mirsadraee, S and Padley, S and Sheikh, A and Singh, S},
doi = {ehjcr/ytaa470},
journal = {European Heart Journal: Case Reports},
pages = {1--7},
title = {Corona Virus Disease 2019 in situ arterial and venous thrombosis in critically ill patients: a case series},
url = {http://dx.doi.org/10.1093/ehjcr/ytaa470},
volume = {4},
year = {2020}
}

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TY  - JOUR
AB  - BackgroundCorona Virus Disease 2019 (COVID-19) pneumonitis associated with severe respiratory failure carries a high mortality. Coagulopathy has emerged as a significant contributor to thrombotic complications.Case summaryWe describe two cases of severe COVID-19 pneumonitis refractory to conventional mechanical ventilation and proning position, transferred to our specialist centre for cardiorespiratory failure. Cross-sectional imaging demonstrated concurrent venous and aortic thrombosis with end-organ ischaemic changes. One patient received thrombolysis with a partial response. This could not be offered to the other patient due to a recent haemorrhagic event. Both patients died of multi-organ failure in the hospital.DiscussionConcurrent aortic and venous thromboses are rare. This finding in COVID-19 cases, who were both critically ill patients, likely reflects the strongly thrombogenic nature of this illness which ultimately contributed to poor outcomes. The absence of deep vein thrombosis or a potential systemic source of embolism suggests in situ thrombosis. Further, the management of anticoagulation and thrombolysis is challenging in patients where an attendant bleeding risk exists.
AU  - Castro-Verdes,M
AU  - Gkouma,A
AU  - Wort,J
AU  - Ridge,C
AU  - Mirsadraee,S
AU  - Padley,S
AU  - Sheikh,A
AU  - Singh,S
DO  - ehjcr/ytaa470
EP  - 7
PY  - 2020///
SN  - 2514-2119
SP  - 1
TI  - Corona Virus Disease 2019 in situ arterial and venous thrombosis in critically ill patients: a case series
T2  - European Heart Journal: Case Reports
UR  - http://dx.doi.org/10.1093/ehjcr/ytaa470
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000646047700152&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://academic.oup.com/ehjcr/article/4/6/1/6032477
UR  - http://hdl.handle.net/10044/1/91367
VL  - 4
ER  -

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