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@article{Sepanlou:2020:10.1016/s2468-1253(19)30349-8,
author = {Sepanlou, SG and Safiri, S and Bisignano, C and Ikuta, KS and Merat, S and Saberifiroozi, M and Poustchi, H and Tsoi, D and Colombara, DV and Abdoli, A and Adedoyin, RA and Afarideh, M and Agrawal, S and Ahmad, S and Ahmadian, E and Ahmadpour, E and Akinyemiju, T and Akunna, CJ and Alipour, V and Almasi-Hashiani, A and Almulhim, AM and Al-Raddadi, RM and Alvis-Guzman, N and Anber, NH and Angus, C and Anoushiravani, A and Arabloo, J and Araya, EM and Asmelash, D and Ataeinia, B and Ataro, Z and Atout, MMW and Ausloos, F and Awasthi, A and Badawi, A and Banach, M and Bejarano, Ramirez DF and Bhagavathula, AS and Bhala, N and Bhattacharyya, K and Biondi, A and Bolla, SR and Boloor, A and Borzì, AM and Butt, ZA and Cámera, LLAA and Campos-Nonato, IR and Carvalho, F and Chu, D-T and Chung, S-C and Cortesi, PA and Costa, VM and Cowie, BC and Daryani, A and de, Courten B and Demoz, GT and Desai, R and Dharmaratne, SD and Djalalinia, S and Do, HT and Dorostkar, F and Drake, TM and Dubey, M and},
doi = {10.1016/s2468-1253(19)30349-8},
journal = {The Lancet Gastroenterology & Hepatology},
pages = {245--266},
title = {The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017},
url = {http://dx.doi.org/10.1016/s2468-1253(19)30349-8},
volume = {5},
year = {2020}
}

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TY  - JOUR
AB  - BackgroundCirrhosis and other chronic liver diseases (collectively referred to as cirrhosis in this paper) are a major cause of morbidity and mortality globally, although the burden and underlying causes differ across locations and demographic groups. We report on results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 on the burden of cirrhosis and its trends since 1990, by cause, sex, and age, for 195 countries and territories.MethodsWe used data from vital registrations, vital registration samples, and verbal autopsies to estimate mortality. We modelled prevalence of total, compensated, and decompensated cirrhosis on the basis of hospital and claims data. Disability-adjusted life-years (DALYs) were calculated as the sum of years of life lost due to premature death and years lived with disability. Estimates are presented as numbers and age-standardised or age-specific rates per 100000 population, with 95% uncertainty intervals (UIs). All estimates are presented for five causes of cirrhosis: hepatitis B, hepatitis C, alcohol-related liver disease, non-alcoholic steatohepatitis (NASH), and other causes. We compared mortality, prevalence, and DALY estimates with those expected according to the Socio-demographic Index (SDI) as a proxy for the development status of regions and countries.FindingsIn 2017, cirrhosis caused more than 1·32 million (95% UI 1·27–1·45) deaths (440000 [416000–518000; 33·3%] in females and 883000 [838000–967000; 66·7%] in males) globally, compared with less than 899000 (829000–948000) deaths in 1990. Deaths due to cirrhosis constituted 2·4% (2·3–2·6) of total deaths globally in 2017 compared with 1·9% (1·8–2·0) in 1990. Despite an increase in the number of deaths, the age-standardised death rate decreased from 21·0 (19·2–22·3) per 100000 population in 1990 to 16&mid
AU  - Sepanlou,SG
AU  - Safiri,S
AU  - Bisignano,C
AU  - Ikuta,KS
AU  - Merat,S
AU  - Saberifiroozi,M
AU  - Poustchi,H
AU  - Tsoi,D
AU  - Colombara,DV
AU  - Abdoli,A
AU  - Adedoyin,RA
AU  - Afarideh,M
AU  - Agrawal,S
AU  - Ahmad,S
AU  - Ahmadian,E
AU  - Ahmadpour,E
AU  - Akinyemiju,T
AU  - Akunna,CJ
AU  - Alipour,V
AU  - Almasi-Hashiani,A
AU  - Almulhim,AM
AU  - Al-Raddadi,RM
AU  - Alvis-Guzman,N
AU  - Anber,NH
AU  - Angus,C
AU  - Anoushiravani,A
AU  - Arabloo,J
AU  - Araya,EM
AU  - Asmelash,D
AU  - Ataeinia,B
AU  - Ataro,Z
AU  - Atout,MMW
AU  - Ausloos,F
AU  - Awasthi,A
AU  - Badawi,A
AU  - Banach,M
AU  - Bejarano,Ramirez DF
AU  - Bhagavathula,AS
AU  - Bhala,N
AU  - Bhattacharyya,K
AU  - Biondi,A
AU  - Bolla,SR
AU  - Boloor,A
AU  - Borzì,AM
AU  - Butt,ZA
AU  - Cámera,LLAA
AU  - Campos-Nonato,IR
AU  - Carvalho,F
AU  - Chu,D-T
AU  - Chung,S-C
AU  - Cortesi,PA
AU  - Costa,VM
AU  - Cowie,BC
AU  - Daryani,A
AU  - de,Courten B
AU  - Demoz,GT
AU  - Desai,R
AU  - Dharmaratne,SD
AU  - Djalalinia,S
AU  - Do,HT
AU  - Dorostkar,F
AU  - Drake,TM
AU  - Dubey,M
AU  - Duncan,BB
AU  - Effiong,A
AU  - Eftekhari,A
AU  - Elsharkawy,A
AU  - Etemadi,A
AU  - Farahmand,M
AU  - Farzadfar,F
AU  - Fernandes,E
AU  - Filip,I
AU  - Fischer,F
AU  - Gebremedhin,KBB
AU  - Geta,B
AU  - Gilani,SA
AU  - Gill,PS
AU  - Gutirrez,RA
AU  - Haile,MT
AU  - Haj-Mirzaian,A
AU  - Hamid,SS
AU  - Hasankhani,M
AU  - Hasanzadeh,A
AU  - Hashemian,M
AU  - Hassen,HY
AU  - Hay,SI
AU  - Hayat,K
AU  - Heidari,B
AU  - Henok,A
AU  - Hoang,CL
AU  - Hostiuc,M
AU  - Hostiuc,S
AU  - Hsieh,VC-R
AU  - Igumbor,EU
AU  - Ilesanmi,OS
AU  - Irvani,SSN
AU  - Jafari,Balalami N
AU  - James,SL
AU  - Jeemon,P
AU  - Jha,RP
AU  - Jonas,JB
AU  - Jozwiak,JJ
AU  - Kabir,A
AU  - Kasaeian,A
AU  - Kassaye,HG
AU  - Kefale,AT
AU  - Khalilov,R
AU  - Khan,MA
AU  - Khan,EA
AU  - Khater,A
AU  - Kim,YJ
AU  - Koyanagi,A
AU  - La,Vecchia C
AU  - Lim,L-L
AU  - Lopez,AD
AU  - Lorkowski,S
AU  - Lotufo,PA
AU  - Lozano,R
AU  - Magdy,Abd El Razek M
AU  - Mai,HT
AU  - Manafi,N
AU  - Manafi,A
AU  - Mansournia,MA
AU  - Mantovani,LG
AU  - Mazzaglia,G
AU  - Mehta,D
AU  - Mendoza,W
AU  - Menezes,RG
AU  - Mengesha,MM
AU  - Meretoja,TJ
AU  - Mestrovic,T
AU  - Miazgowski,B
AU  - Miller,TR
AU  - Mirrakhimov,EM
AU  - Mithra,P
AU  - Moazen,B
AU  - Moghadaszadeh,M
AU  - Mohammadian-Hafshejani,A
AU  - Mohammed,S
AU  - Mokdad,AH
AU  - Montero-Zamora,PA
AU  - Moradi,G
AU  - Naimzada,MD
AU  - Nayak,V
AU  - Negoi,I
AU  - Nguyen,TH
AU  - Ofori-Asenso,R
AU  - Oh,I-H
AU  - Olagunju,TO
AU  - Padubidri,JR
AU  - Pakshir,K
AU  - Pana,A
AU  - Pathak,M
AU  - Pourshams,A
AU  - Rabiee,N
AU  - Radfar,A
AU  - Rafiei,A
AU  - Ramezanzadeh,K
AU  - Rana,SMM
AU  - Rawaf,S
AU  - Rawaf,DL
AU  - Reiner,RC
AU  - Roever,L
AU  - Room,R
AU  - Roshandel,G
AU  - Safari,S
AU  - Samy,AM
AU  - Sanabria,J
AU  - Sartorius,B
AU  - Schmidt,MI S
DO  - 10.1016/s2468-1253(19)30349-8
EP  - 266
PY  - 2020///
SN  - 2468-1253
SP  - 245
TI  - The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
T2  - The Lancet Gastroenterology & Hepatology
UR  - http://dx.doi.org/10.1016/s2468-1253(19)30349-8
UR  - https://www.sciencedirect.com/science/article/pii/S2468125319303498?via%3Dihub
UR  - http://hdl.handle.net/10044/1/76647
VL  - 5
ER  -

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