Imperial College London
Alternate

ProfessorSudhinThayyil

Faculty of Medicine, Department of Brain Sciences

Professor of Perinatal Neuroscience
 
 
 
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Contact

 

+44 (0)20 3313 8515s.thayyil

 
 
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Location

 

529Hammersmith HouseHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lally:2014:10.1136/archdischild-2014-306576.146,
author = {Lally, P and Pauliah, S and Price, D and Bainbridge, A and Addison, S and Soe, A and Pattnayak, S and Satodia, P and Wayte, S and Ng'andwe, E and Clarke, P and Johnson, G and Harigopal, S and English, P and Abernethy, LJ and Turner, M and Cheong, J and Shankaran, S and Cady, E and Thayyil, S},
doi = {10.1136/archdischild-2014-306576.146},
journal = {Arch Dis Child Fetal Neonatal Ed},
title = {PC.45Quantification of N-Acetylaspartate Concentration in the Neonatal Brain: Initial Results from the Multi-Centre Marble Study.},
url = {http://dx.doi.org/10.1136/archdischild-2014-306576.146},
volume = {99 Suppl 1},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Early cerebral proton magnetic resonance spectroscopy (MRS) predicts medium-term outcomes in neonatal encephalopathy (NE). Metabolite peak-area ratios are most commonly used for prognosis, but conflate pathological information from different metabolites. N-acetylaspartate (NAA) is predominantly neuronal and neuronal loss should result in reduced NAA absolute-concentration ([NAA]). Thus, thalamic [NAA] should offer significant prognostic value but is difficult to measure in a clinical setting. We have established a protocol for multi-centre [NAA] measurement with the aim to use it as a surrogate biomarker in phase II clinical trials.
AU  - Lally,P
AU  - Pauliah,S
AU  - Price,D
AU  - Bainbridge,A
AU  - Addison,S
AU  - Soe,A
AU  - Pattnayak,S
AU  - Satodia,P
AU  - Wayte,S
AU  - Ng'andwe,E
AU  - Clarke,P
AU  - Johnson,G
AU  - Harigopal,S
AU  - English,P
AU  - Abernethy,LJ
AU  - Turner,M
AU  - Cheong,J
AU  - Shankaran,S
AU  - Cady,E
AU  - Thayyil,S
DO  - 10.1136/archdischild-2014-306576.146
PY  - 2014///
TI  - PC.45Quantification of N-Acetylaspartate Concentration in the Neonatal Brain: Initial Results from the Multi-Centre Marble Study.
T2  - Arch Dis Child Fetal Neonatal Ed
UR  - http://dx.doi.org/10.1136/archdischild-2014-306576.146
UR  - http://www.ncbi.nlm.nih.gov/pubmed/25021271
VL  - 99 Suppl 1
ER  -
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