ProfessorSianHarding

Faculty of Medicine, National Heart & Lung Institute

Professor of Cardiac Pharmacology

Contact

Location

435ICTEM buildingHammersmith Campus

Summary

Sian Harding is Professor of Cardiac Pharmacology at the National Heart and Lung Institute, Imperial College London, and Director of the Imperial Cardiac Regenerative Medicine Centre https://www.imperial.ac.uk/bhf-regenerative-medicine/.

She obtained her Ph.D. in Pharmacology from King's College, London in 1981, and since then the primary focus of her work has been cardiomyocyte function in the failing heart. This has extended to gene therapy to modulate cardiomyocyte function, and she was Scientific PI for the UK's first clinical trial on myocardial gene therapy. More recently the scope has extended to the characterisation of cardiomyocytes derived from embryonic stem cells, and their use in cardiac repair, tissue engineering and drug discovery.

Professor Harding is Past-President of the European Section of the International Society for Heart Research, is on the Board of the British Society for Gene and Cell Therapy and has been elected as a Fellow to the AHA, ESC and ISHR. She was Special Advisor to the House of Commons Science and Technology Select Committee on Regenerative Medicine and is now a member of the CGT Catapult: Pluripotent stem cells programme Advisory Panel.

Professor Harding delivered her Inaugural Lecture, entitled 'Reviving the Failing Heart: one cell at a time', on 3 April 2007. The abstract and other details of the lecture can be found here.

Publications

Journals

Wright PT, Gorelik J, Harding SE, 2021, Electrophysiological remodeling: cardiac t-tubules and β-adrenoceptors, Cells, Vol:10, ISSN:2073-4409

Fu L, Zhang H, Machuki JO, et al.Fu L, Zhang H, Machuki JO, Zhang T, Han L, Sang L, Wu L, Zhao Z, Turley MJ, Hu X, Hou H, Li D, Harding SE, Sun H close, 2021, Reply to: Estrogens for protection from an index and recurrent episodes of takotsubo syndrome? REPLY, Journal of Endocrinology, Vol:250, ISSN:0022-0795, Pages:L3-L3

Jabbour R, Owen T, Pandey P, et al.Jabbour R, Owen T, Pandey P, reinsch M, Wang B, King O, Couch L, Pantou D, Pitcher D, Chowdhury R, Pitoulis F, Handa B, Kit-Anan W, Perbellini F, myles R, Stuckey D, dunne M, Shanmuganathan M, Peters N, Ng FS, weinberger F, Terracciano C, smith G, Eschenhagen T, Harding S close, 2021, In vivo grafting of large engineered heart tissue patches for cardiac repair, Jci Insight, Vol:6, ISSN:2379-3708, Pages:1-13

Basnett P, Matharu RK, Taylor CS, et al.Basnett P, Matharu RK, Taylor CS, Illangakoon U, Dawson J, Kanczler JM, Behbehani M, Humphrey E, Majid Q, Lukasiewicz B, Nigmatullin R, Heseltine P, Oreffo ROC, Haycock JW, Terracciano C, Harding SE, Edirisinghe M, Roy I close, 2021, Harnessing Polyhydroxyalkanoates and Pressurized Gyration for Hard and Soft Tissue Engineering, Acs Applied Materials & Interfaces, Vol:13, ISSN:1944-8244, Pages:32624-32639

Couch LS, Fiedler J, Chick G, et al.Couch LS, Fiedler J, Chick G, Clayton R, Dries E, Wienecke LM, Fu L, Fourre J, Pandey P, Derda AA, Wang BX, Jabbour R, Shanmuganathan M, Wright P, Lyon AR, Terracciano CM, Thum T, Harding SE close, 2021, Circulating microRNAs predispose to takotsubo syndrome following high-dose adrenaline exposure, Cardiovascular Research, ISSN:0008-6363

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