ProfessorSianHarding

Faculty of Medicine, National Heart & Lung Institute

Professor of Cardiac Pharmacology

Contact

Location

435ICTEM buildingHammersmith Campus

Summary

Sian Harding is Professor of Cardiac Pharmacology at the National Heart and Lung Institute, Imperial College London, and a co-investigator within the UKRMP Immunomodulation Hub.

She obtained her Ph.D. in Pharmacology from King's College, London in 1981, and since then the primary focus of her work has been cardiomyocyte function in the failing heart. This has extended to gene therapy to modulate cardiomyocyte function, and she is Scientific PI for the UK's first clinical trial on myocardial gene therapy. More recently the scope has extended to the characterisation of cardiomyocytes derived from embryonic stem cells, and their use in cardiac repair, tissue engineering and drug discovery.

Professor Harding is Past-President of the European Section of the International Society for Heart Research and Fellow of the AHA, ESC and ISHR. She sits on the Nuffield Council on Bioethics and the Scientific Advisory Board of the PPP "Stem Cells for Safer Medicines".

Professor Harding delivered her Inaugural Lecture, entitled 'Reviving the Failing Heart: one cell at a time', on 3 April 2007. The abstract and other details of the lecture can be found here.

Publications

Journals

Constantinou C, Miranda Almeida A, Chaves Guerrero P, et al.Constantinou C, Miranda Almeida A, Chaves Guerrero P, Bellahcene M, Massaia A, Cheng K, Samari S, Rothery S, Chandler A, Schwarz R, Harding S, Punjabi P, Schneider MD, Noseda M close, Human pluripotent stem cell-derived cardiomyocytes as a targetplatform for paracrine protection by cardiac mesenchymal stromalcells, Scientific Reports, ISSN:2045-2322

Pitoulis FG, Hasan W, Papadaki M, et al.Pitoulis FG, Hasan W, Papadaki M, Clavere NG, Perbellini F, Harding SE, Kirk JA, Boateng SY, de Tombe PP, Terracciano CM close, 2020, Intact myocardial preparations reveal intrinsic transmural heterogeneity in cardiac mechanics, Journal of Molecular and Cellular Cardiology, Vol:141, ISSN:0022-2828, Pages:11-16

Schobesberger S, Wright PT, Poulet C, et al.Schobesberger S, Wright PT, Poulet C, Mardones JLSA, Mansfield C, Friebe A, Harding SE, Balligand J-L, Nikolaev VO, Gorelik J close, 2020, beta(3)-Adrenoceptor redistribution impairs NO/cGMP/PDE2 signalling in failing cardiomyocytes, Elife, Vol:9, ISSN:2050-084X, Pages:1-15

Fiedler LR, Chapman K, Xie M, et al.Fiedler LR, Chapman K, Xie M, Maifoshie E, Jenkins M, Golforoush PA, Bellahcene M, Noseda M, Faust D, Jarvis A, Newton G, Paiva MA, Harada M, Stuckey DJ, Song W, Habib J, Narasimhan P, Aqil R, Sanmugalingam D, Yan R, Pavanello L, Sano M, Wang SC, Sampson RD, Kanayaganam S, Taffet GE, Michael LH, Entman ML, Tan T-H, Harding SE, Low CMR, Tralau-Stewart C, Perrior T, Schneider MD close, 2020, MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo (vol 24, 579.e1,2019), Cell Stem Cell, Vol:26, ISSN:1934-5909, Pages:458-458

Sparks H, Dvinskikh L, Firth J, et al.Sparks H, Dvinskikh L, Firth J, Francis A, Harding S, Paterson C, MacLeod K, Dunsby C close, Development a flexible light-sheet fluorescence microscope for high-speed 3D imaging of calcium dynamics and 3D imaging of cellular microstructure, Journal of Biophotonics, ISSN:1864-063X

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