Summary
Sian Harding is Professor of Cardiac Pharmacology at the National Heart and Lung Institute, Imperial College London, and Director of the Imperial Cardiac Regenerative Medicine Centre https://www.imperial.ac.uk/bhf-regenerative-medicine/.
She obtained her Ph.D. in Pharmacology from King's College, London in 1981, and since then the primary focus of her work has been cardiomyocyte function in the failing heart. This has extended to gene therapy to modulate cardiomyocyte function, and she was Scientific PI for the UK's first clinical trial on myocardial gene therapy. More recently the scope has extended to the characterisation of cardiomyocytes derived from embryonic stem cells, and their use in cardiac repair, tissue engineering and drug discovery.
Professor Harding is Past-President of the European Section of the International Society for Heart Research, is on the Board of the British Society for Gene and Cell Therapy and has been elected as a Fellow to the AHA, ESC and ISHR. She was Special Advisor to the House of Commons Science and Technology Select Committee on Regenerative Medicine and is now a member of the CGT Catapult: Pluripotent stem cells programme Advisory Panel.
Professor Harding delivered her Inaugural Lecture, entitled 'Reviving the Failing Heart: one cell at a time', on 3 April 2007. The abstract and other details of the lecture can be found here.
Publications
Journals
Kondrashov A, Mohd Yusof NAN, Hasan A, et al., 2021, CRISPR/Cas9-mediated generation and analysis of N terminus polymorphic models of β2AR in isogenic hPSC-derived cardiomyocytes., Mol Ther Methods Clin Dev, Vol:20, ISSN:2329-0501, Pages:39-53
Crestani T, Steichen C, Neri E, et al., 2020, Electrical stimulation applied during differentiation drives the hiPSC-CMs towards a mature cardiac conduction-like cells, Biochemical and Biophysical Research Communications, Vol:533, ISSN:0006-291X, Pages:376-382
Forte E, Perkins B, Sintou A, et al., 2020, Cross-priming dendritic cells exacerbate immunopathology after ischemic tissue damage in the heart, Circulation, ISSN:0009-7322
Forte E, Panahi M, Baxan N, et al., 2020, Type 2 MI induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart, Journal of Cellular and Molecular Medicine, ISSN:1582-1838
Kit-Anan W, Mazo M, Wang BX, et al., 2020, Multiplexing physical stimulation on single human induced pluripotent stem cell-derived cardiomyocytes for phenotype modulation, Biofabrication, ISSN:1758-5082