Publications

BibTex format

@article{Hill:2015:10.1002/oby.21000,
author = {Hill, NE and Fallowfield, JL and Delves, SK and Ardley, C and Stacey, M and Ghatei, M and Bloom, SR and Frost, G and Brett, SJ and Wilson, DR and Murphy, KG},
doi = {10.1002/oby.21000},
journal = {Obesity (Silver Spring)},
pages = {608--614},
title = {Changes in gut hormones and leptin in military personnel during operational deployment in Afghanistan.},
url = {http://dx.doi.org/10.1002/oby.21000},
volume = {23},
year = {2015}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: Understanding the mechanisms that drive weight loss in a lean population may elucidate systems that regulate normal energy homeostasis. This prospective study of British military volunteers investigated the effects of a 6-month deployment to Afghanistan on energy balance and circulating concentrations of specific appetite-regulating hormones. METHODS: Measurements were obtained twice in the UK (during the Pre-deployment period) and once in Afghanistan, at Mid-deployment. Body mass, body composition, food intake, and appetite-regulatory hormones (leptin, active and total ghrelin, PYY, PP, GLP-1) were measured. RESULTS: Repeated measures analysis of 105 volunteers showed body mass decreased by 4.9% ± 3.7% (P < 0.0001) during the first half of the deployment. Leptin concentrations were significantly correlated with percentage body fat at each time point. The reduction in percentage body fat between Pre-deployment and Mid-deployment was 8.6%, with a corresponding 48% decrease in mean circulating leptin. Pre-deployment leptin and total and active ghrelin levels correlated with subsequent change in body mass; however. no changes were observed in the anorectic gut hormones GLP-1, PP, or PYY. CONCLUSIONS: These data suggest that changes in appetite-regulating hormones in front line military personnel occur in response to, but do not drive, reductions in body mass.
AU  - Hill,NE
AU  - Fallowfield,JL
AU  - Delves,SK
AU  - Ardley,C
AU  - Stacey,M
AU  - Ghatei,M
AU  - Bloom,SR
AU  - Frost,G
AU  - Brett,SJ
AU  - Wilson,DR
AU  - Murphy,KG
DO  - 10.1002/oby.21000
EP  - 614
PY  - 2015///
SP  - 608
TI  - Changes in gut hormones and leptin in military personnel during operational deployment in Afghanistan.
T2  - Obesity (Silver Spring)
UR  - http://dx.doi.org/10.1002/oby.21000
UR  - https://www.ncbi.nlm.nih.gov/pubmed/25612171
UR  - http://hdl.handle.net/10044/1/21248
VL  - 23
ER  -

Download

ProfessorStephenBrett

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)