Imperial College London
Alternate

ProfessorStuartCook

Faculty of Medicine, Institute of Clinical Sciences

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3313 1346stuart.cook

 
 
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Location

 

RF 16Sydney StreetRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ng:2020:10.1038/s12276-020-00531-5,
author = {Ng, B and Cook, SA and Schafer, S},
doi = {10.1038/s12276-020-00531-5},
journal = {Experimental and Molecular Medicine},
pages = {1871--1878},
title = {Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway},
url = {http://dx.doi.org/10.1038/s12276-020-00531-5},
volume = {52},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Interleukin (IL)-11 evolved as part of the innate immune response. In the human lung, IL-11 upregulation has been associated with viral infections and a range of fibroinflammatory diseases, including idiopathic pulmonary fibrosis. Transforming growth factor-beta (TGFβ) and other disease factors can initiate an autocrine loop of IL-11 signaling in pulmonary fibroblasts, which, in a largely ERK-dependent manner, triggers the translation of profibrotic proteins. Lung epithelial cells also express the IL-11 receptor and transition into a mesenchymal-like state in response to IL-11 exposure. In mice, therapeutic targeting of IL-11 with antibodies can arrest and reverse bleomycin-induced pulmonary fibrosis and inflammation. Intriguingly, fibroblast-specific blockade of IL-11 signaling has anti-inflammatory effects, which suggests that lung inflammation is sustained, in part, through IL-11 activity in the stroma. Proinflammatory fibroblasts and their interaction with the damaged epithelium may represent an important but overlooked driver of lung disease. Initially thought of as a protective cytokine, IL-11 is now increasingly recognized as an important determinant of lung fibrosis, inflammation, and epithelial dysfunction.
AU  - Ng,B
AU  - Cook,SA
AU  - Schafer,S
DO  - 10.1038/s12276-020-00531-5
EP  - 1878
PY  - 2020///
SN  - 0378-8512
SP  - 1871
TI  - Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway
T2  - Experimental and Molecular Medicine
UR  - http://dx.doi.org/10.1038/s12276-020-00531-5
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000595038800002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/s12276-020-00531-5
UR  - http://hdl.handle.net/10044/1/105621
VL  - 52
ER  -
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