Imperial College London
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Professor Thanos Athanasiou MD PhD MBA FECTS FRCS

Faculty of Medicine, Department of Surgery & Cancer

Professor of Cardiovascular Sciences
 
 
 
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Contact

 

t.athanasiou

 
 
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Location

 

1022Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jamel:2017:10.1007/s10120-017-0749-y,
author = {Jamel, S and Markar, SR and Malietzis, G and Acharya, A and Athanasiou, T and Hanna, GB},
doi = {10.1007/s10120-017-0749-y},
journal = {Gastric Cancer},
pages = {10--18},
title = {Prognostic significance of peritoneal lavage cytology in staging gastric cancer: systematic review and meta-analysis},
url = {http://dx.doi.org/10.1007/s10120-017-0749-y},
volume = {21},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundPeritoneal cytology has been used as a part of the cancer staging of gastric cancer patients. The primary aim of this systematic review was to evaluate the value of peritoneal cytology as part of the staging of gastric cancer and survival prediction. The second aim was to establish if positive cytology may be modified by neoadjuvant therapy, to improve prognosis.MethodsAn electronic literature search was performed using Embase, Medline, Web of Science, and Cochrane library databases up to January 2016. The logarithm of the hazard ratio (HR) with 95% confidence intervals (CI) was used as the primary summary statistic. Comparative studies were used, and the outcome measure was survival in three groups: (1) positive versus negative cytology at staging laparoscopy immediately preceding surgery; (2) effect of neoadjuvant therapy on cytology and survival; and (3) positive cytology in the absence of macroscopic peritoneal disease was compared with obvious macroscopic peritoneal disease.ResultsPooled analysis demonstrated that positive cytology was associated with significantly reduced overall survival (HR, 3.46; 95% CI, 2.77–4.31; P < 0.0001). Interestingly, negative cytology following neoadjuvant chemotherapy was associated with significantly improved overall survival (HR, 0.42; 95% CI, 0.31–0.57; P < 0.0001). The absence of macroscopic peritoneal disease with positive cytology was associated with significantly improved overall survival (HR, 0.64; 95% CI, 0.56–0.73; P < 0.0001).ConclusionThis study suggests that patients with initial positive cytology may have a good prognosis following neoadjuvant treatment if the cytology results change to negative after treatment.
AU  - Jamel,S
AU  - Markar,SR
AU  - Malietzis,G
AU  - Acharya,A
AU  - Athanasiou,T
AU  - Hanna,GB
DO  - 10.1007/s10120-017-0749-y
EP  - 18
PY  - 2017///
SN  - 1436-3291
SP  - 10
TI  - Prognostic significance of peritoneal lavage cytology in staging gastric cancer: systematic review and meta-analysis
T2  - Gastric Cancer
UR  - http://dx.doi.org/10.1007/s10120-017-0749-y
UR  - http://hdl.handle.net/10044/1/56206
VL  - 21
ER  -
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