Imperial College London
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Professor Thanos Athanasiou MD PhD MBA FECTS FRCS

Faculty of Medicine, Department of Surgery & Cancer

Professor of Cardiovascular Sciences
 
 
 
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Contact

 

t.athanasiou

 
 
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Location

 

1022Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Tan:2016:icvts/ivw312,
author = {Tan, MKH and Jarral, OA and Thong, EHE and Kidher, E and Uppal, R and Punjabi, PP and Athanasiou, T},
doi = {icvts/ivw312},
journal = {Interactive Cardiovascular and Thoracic Surgery},
pages = {265--272},
title = {Quality of life after mitral valve intervention},
url = {http://dx.doi.org/10.1093/icvts/ivw312},
volume = {24},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Advancements in surgical technique and understanding of the pathophysiology of mitral valve (MV) dysfunction have led to improved outcomes. Seen as a development beyond measures of morbidity and mortality, health-related quality-of-life (HRQOL) outcome measures are becoming increasingly popular. These measures are important because complications following routine (i.e. low-risk) operations on the MV are uncommon and further markers of outcome are needed. Surgeons are increasingly operating earlier on asymptomatic patients and will need to prove that HRQOL is not impacted. Novel minimally invasive and transcatheter technologies will also need to demonstrate satisfactory HRQOL outcomes prior to widespread use. This systematic review provides an overview of all available literature detailing HRQOL in patients receiving MV interventions. In the 43 studies included, 6865 patients underwent procedures ranging from open replacement to percutaneous repair using devices such as the Mitraclip Clip Delivery System (MitraClip) (Abbott Vascular, Santa Clara, CA, USA). Most studies performed baseline HRQOL assessment, allowing postinterventional comparison. While the underlying literature had deficiencies, most studies report acceptable postintervention HRQOL that was comparable to that of matched general populations. Patient-specific (e.g. female gender, renal dysfunction) and surgical-specific factors (e.g. replacement instead of repair, elevated transmitral gradient) were identified that predispose patients to poorer long-term HRQOL outcomes. These factors are important for clinicians developing strategies to maximize their HRQOL outcomes. Future randomized studies would benefit from HRQOL measurements at specific time points to allow large-scale comparisons. Establishing a common HRQOL instrument for use in MV intervention studies may support detailed comparisons between specific techniques. Physical activity monitors, physiological biomarkers and radiological markers could a
AU  - Tan,MKH
AU  - Jarral,OA
AU  - Thong,EHE
AU  - Kidher,E
AU  - Uppal,R
AU  - Punjabi,PP
AU  - Athanasiou,T
DO  - icvts/ivw312
EP  - 272
PY  - 2016///
SN  - 1569-9293
SP  - 265
TI  - Quality of life after mitral valve intervention
T2  - Interactive Cardiovascular and Thoracic Surgery
UR  - http://dx.doi.org/10.1093/icvts/ivw312
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000397261100019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/45341
VL  - 24
ER  -
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