Imperial College London
Alternate

ProfessorThomasBrand

Faculty of Medicine, National Heart & Lung Institute

Chair in Developmental Dynamics
 
 
 
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Contact

 

+44 (0)20 7594 8744t.brand Website CV

 
 
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Assistant

 

Miss Cheryl Costello +44 (0)20 7594 3001

 
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Location

 

433ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{MacLellan:1993:10.1161/01.res.73.5.783,
author = {MacLellan, WR and Brand, T and Schneider, MD},
doi = {10.1161/01.res.73.5.783},
journal = {Circ Res},
pages = {783--791},
title = {Transforming growth factor-beta in cardiac ontogeny and adaptation.},
url = {http://dx.doi.org/10.1161/01.res.73.5.783},
volume = {73},
year = {1993}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The transforming growth factor-beta (TGF-beta) superfamily comprises a set of regulatory peptides with multiple effects on cell growth and differentiation. The elaborate regulation of TGF-beta s during embryonic development of the heart, the upregulation of TGF-beta after hemodynamic stress, and the impact of TGF-beta on cardiac gene expression together imply a prominent functional role for this family of growth factors in cardiac organogenesis and hypertrophy. Basal and TGF-beta-induced expression of skeletal alpha-actin, one of several genes specifically associated with developing or hypertrophied myocardium, each are contingent on transcriptional activation by serum response factor. A truncated form of the type II TGF-beta receptor, created by deletion of the cytoplasmic kinase domain, acts as a dominant suppressor of TGF-beta signal transduction in cultured cardiac muscle cells and may provide a suitable means to establish the functions of TGF-beta in vivo.
AU  - MacLellan,WR
AU  - Brand,T
AU  - Schneider,MD
DO  - 10.1161/01.res.73.5.783
EP  - 791
PY  - 1993///
SN  - 0009-7330
SP  - 783
TI  - Transforming growth factor-beta in cardiac ontogeny and adaptation.
T2  - Circ Res
UR  - http://dx.doi.org/10.1161/01.res.73.5.783
UR  - https://www.ncbi.nlm.nih.gov/pubmed/8403249
VL  - 73
ER  -
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