Imperial College London
Portrait Picture

Professor Timothy Constandinou

Faculty of Engineering, Department of Electrical and Electronic Engineering

Professor of Bioelectronics
 
 
 
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Contact

 

+44 (0)20 7594 0790t.constandinou Website

 
 
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Assistant

 

Miss Izabela Wojcicka-Grzesiak +44 (0)20 7594 0701

 
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Location

 

B407Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Tossell:2023:10.1038/s41593-023-01430-4,
author = {Tossell, K and Yu, X and Giannos, P and Anuncibay, Soto B and Nollet, M and Yustos, R and Miracca, G and Vicente, M and Miao, A and Hsieh, B and Ma, Y and Vysstoski, A and Constandinou, T and Franks, N and Wisden, W},
doi = {10.1038/s41593-023-01430-4},
journal = {Nature Neuroscience},
pages = {1805--1819},
title = {Somatostatin neurons in prefrontal cortex initiate sleep preparatory behavior and sleep via the preoptic and lateral hypothalamus},
url = {http://dx.doi.org/10.1038/s41593-023-01430-4},
volume = {26},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The prefrontal cortex (PFC) enables mammals to respond to situations, including internal states, with appropriate actions. One such internal state could be ‘tiredness’. Here, using activity tagging in the mouse PFC, we identified particularly excitable, fast-spiking, somatostatin-expressing, γ-aminobutyric acid (GABA) (PFCSst-GABA) cells that responded to sleep deprivation. These cells projected to the lateral preoptic (LPO) hypothalamus and the lateral hypothalamus (LH). Stimulating PFCSst-GABA terminals in the LPO hypothalamus caused sleep-preparatory behavior (nesting, elevated theta power and elevated temperature), and stimulating PFCSst-GABA terminals in the LH mimicked recovery sleep (non-rapid eye-movement sleep with higher delta power and lower body temperature). PFCSst-GABA terminals had enhanced activity during nesting and sleep, inducing inhibitory postsynaptic currents on diverse cells in the LPO hypothalamus and the LH. The PFC also might feature in deciding sleep location in the absence of excessive fatigue. These findings suggest that the PFC instructs the hypothalamus to ensure that optimal sleep takes place in a suitable place.
AU  - Tossell,K
AU  - Yu,X
AU  - Giannos,P
AU  - Anuncibay,Soto B
AU  - Nollet,M
AU  - Yustos,R
AU  - Miracca,G
AU  - Vicente,M
AU  - Miao,A
AU  - Hsieh,B
AU  - Ma,Y
AU  - Vysstoski,A
AU  - Constandinou,T
AU  - Franks,N
AU  - Wisden,W
DO  - 10.1038/s41593-023-01430-4
EP  - 1819
PY  - 2023///
SN  - 1097-6256
SP  - 1805
TI  - Somatostatin neurons in prefrontal cortex initiate sleep preparatory behavior and sleep via the preoptic and lateral hypothalamus
T2  - Nature Neuroscience
UR  - http://dx.doi.org/10.1038/s41593-023-01430-4
UR  - https://www.nature.com/articles/s41593-023-01430-4
UR  - http://hdl.handle.net/10044/1/106171
VL  - 26
ER  -
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