Imperial College London
Alternate

PROFESSOR H. TERENCE COOK

Faculty of Medicine, Department of Immunology and Inflammation

Emeritus Professor
 
 
 
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Contact

 

+44 (0)20 3313 2009t.h.cook

 
 
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Assistant

 

Miss Claudia Rocchi +44 (0)20 3313 2315

 
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Location

 

9N9Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bajema:2018:10.1016/j.kint.2017.11.023,
author = {Bajema, IM and Wilhelmus, S and Alpers, CE and Bruijn, JA and Colvin, RB and Cook, HT and D'Agati, VD and Ferrario, F and Haas, M and Jennette, JC and Joh, K and Nast, CC and Noël, L-H and Rijnink, EC and Roberts, ISD and Seshan, SV and Sethi, S and Fogo, AB},
doi = {10.1016/j.kint.2017.11.023},
journal = {Kidney International},
pages = {789--796},
title = {Revision of the International Society of Nephrology/Renal Pathology Society classification for lupus nephritis: clarification of definitions, and modified National Institutes of Health activity and chronicity indices},
url = {http://dx.doi.org/10.1016/j.kint.2017.11.023},
volume = {93},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We present a consensus report pertaining to the improved clarity of definitions and classification of glomerular lesions in lupus nephritis that derived from a meeting of 18 members of an international nephropathology working group in Leiden, Netherlands, in 2016. Here we report detailed recommendations on issues for which we can propose adjustments based on existing evidence and current consensus opinion (phase 1). New definitions are provided for mesangial hypercellularity and for cellular, fibrocellular, and fibrous crescents. The term "endocapillary proliferation" is eliminated and the definition of endocapillary hypercellularity considered in some detail. We also eliminate the class IV-S and IV-G subdivisions of class IV lupus nephritis. The active and chronic designations for class III/IV lesions are replaced by a proposal for activity and chronicity indices that should be applied to all classes. In the activity index, we include fibrinoid necrosis as a specific descriptor. We also make recommendations on issues for which there are limited data at present and that can best be addressed in future studies (phase 2). We propose to proceed to these investigations, with clinicopathologic studies and tests of interobserver reproducibility to evaluate the applications of the proposed definitions and to classify lupus nephritis lesions.
AU  - Bajema,IM
AU  - Wilhelmus,S
AU  - Alpers,CE
AU  - Bruijn,JA
AU  - Colvin,RB
AU  - Cook,HT
AU  - D'Agati,VD
AU  - Ferrario,F
AU  - Haas,M
AU  - Jennette,JC
AU  - Joh,K
AU  - Nast,CC
AU  - Noël,L-H
AU  - Rijnink,EC
AU  - Roberts,ISD
AU  - Seshan,SV
AU  - Sethi,S
AU  - Fogo,AB
DO  - 10.1016/j.kint.2017.11.023
EP  - 796
PY  - 2018///
SN  - 0085-2538
SP  - 789
TI  - Revision of the International Society of Nephrology/Renal Pathology Society classification for lupus nephritis: clarification of definitions, and modified National Institutes of Health activity and chronicity indices
T2  - Kidney International
UR  - http://dx.doi.org/10.1016/j.kint.2017.11.023
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29459092
UR  - http://hdl.handle.net/10044/1/57351
VL  - 93
ER  -
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