Imperial College London
Alternate

ProfessorThomasThum

Faculty of Medicine, National Heart & Lung Institute

Visiting Professor
 
 
 
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Contact

 

t.thum

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Watson:2015:10.1002/ejhf.244,
author = {Watson, CJ and Gupta, SK and O'Connell, E and Thum, S and Glezeva, N and Fendrich, J and Gallagher, J and Ledwidge, M and Grote-Levi, L and McDonald, K and Thum, T},
doi = {10.1002/ejhf.244},
journal = {European Journal of Heart Failure},
pages = {405--415},
title = {MicroRNA signatures differentiate preserved from reduced ejection fraction heart failure},
url = {http://dx.doi.org/10.1002/ejhf.244},
volume = {17},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - AimsDifferentiation of heart failure with reduced (HFrEF) or preserved (HFpEF) ejection fraction independent of echocardiography is challenging in the community. Diagnostic strategies based on monitoring circulating microRNA (miRNA) levels may prove to be of clinical value in the near future. The aim of this study was to identify a novel miRNA signature that could be a useful HF diagnostic tool and provide valuable clinical information on whether a patient has HFrEF or HFpEF.Methods and resultsMiRNA biomarker discovery was carried out on three patient cohorts, no heart failure (no-HF), HFrEF, and HFpEF, using Taqman miRNA arrays. The top five miRNA candidates were selected based on differential expression in HFpEF and HFrEF (miR-30c, −146a, −221, −328, and −375), and their expression levels were also different between HF and no-HF. These selected miRNAs were further verified and validated in an independent cohort consisting of 225 patients. The discriminative value of BNP as a HF diagnostic could be improved by use in combination with any of the miRNA candidates alone or in a panel. Combinations of two or more miRNA candidates with BNP had the ability to improve significantly predictive models to distinguish HFpEF from HFrEF compared with using BNP alone (area under the receiver operating characteristic curve >0.82).ConclusionThis study has shown for the first time that various miRNA combinations are useful biomarkers for HF, and also in the differentiation of HFpEF from HFrEF. The utility of these biomarker combinations can be altered by inclusion of natriuretic peptide. MiRNA biomarkers may support diagnostic strategies in subpopulations of patients with HF.
AU  - Watson,CJ
AU  - Gupta,SK
AU  - O'Connell,E
AU  - Thum,S
AU  - Glezeva,N
AU  - Fendrich,J
AU  - Gallagher,J
AU  - Ledwidge,M
AU  - Grote-Levi,L
AU  - McDonald,K
AU  - Thum,T
DO  - 10.1002/ejhf.244
EP  - 415
PY  - 2015///
SN  - 1879-0844
SP  - 405
TI  - MicroRNA signatures differentiate preserved from reduced ejection fraction heart failure
T2  - European Journal of Heart Failure
UR  - http://dx.doi.org/10.1002/ejhf.244
UR  - http://hdl.handle.net/10044/1/41851
VL  - 17
ER  -
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