Imperial College London
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DrVanessaGarcia Larsen

Faculty of Medicine, National Heart & Lung Institute

Honorary Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 7945vgla

 
 
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Location

 

61Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Alemayohu:2023:10.1016/j.eclinm.2023.102215,
author = {Alemayohu, MA and Zanolin, ME and Cazzoletti, L and Nyasulu, P and Garcia-Larsen, V and GBD, 2019 Sub-Saharan COPD Collaborators},
doi = {10.1016/j.eclinm.2023.102215},
journal = {EClinicalMedicine},
title = {Burden and risk factors of chronic obstructive pulmonary disease in Sub-Saharan African countries, 1990-2019: a systematic analysis for the Global Burden of disease study 2019.},
url = {http://dx.doi.org/10.1016/j.eclinm.2023.102215},
volume = {64},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Sub-Saharan Africa (SSA) has experienced a surge of non-communicable diseases (NCDs) including chronic obstructive pulmonary disease (COPD) over the past two decades. Using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), in this study we have estimated the burden and attributable risk factors of COPD across SSA countries between 1990 and 2019. METHODS: COPD burden and its attributable risk factors were estimated using data from the 2019 GBD. Percentage change was estimated to show the trend of COPD estimates from 1990 to 2019. COPD estimates attributable by risk factors were also reported to ascertain the risk factor that brings the greatest burden by sex and locations (at country and regions level). FINDINGS: In 2019, all-age prevalent cases of COPD in SSA were estimated to be 10.3 million (95% Uncertainty Intervals (UI) 9.7 million to 10.9 million) showing an increase of 117% compared with the number of all-age COPD cases in 1990. From 1990 to 2019, SSA underwent an increased percentage change in all-age YLDs due to COPD ranging from 41% in Lesotho to 203% in Equatorial Guinea. The largest premature mortality due to COPD was reported from Central SSA accounting for 729 subjects (95% UI, 509-1078). The highest rate of DALYs attributable to COPD was observed in Lesotho. Household air pollution from solid fuel was the primary contributor of the age standardized YLDs, death rate, and DALYs rate per 100,000 population. INTERPRETATION: The prevalence of COPD in SSA has had a steady increase over the past three decades and has progressively become a major public health burden across the region. Household air pollution from solid fuel is the primary contributor to COPD related burden, and its percentage contribution showed a similar trend to the reduction of COPD attributed age-standardized DALY rate. The methodological limitations of surveys and datapoints included in the GBD need to be considered when interpreting t
AU  - Alemayohu,MA
AU  - Zanolin,ME
AU  - Cazzoletti,L
AU  - Nyasulu,P
AU  - Garcia-Larsen,V
AU  - GBD,2019 Sub-Saharan COPD Collaborators
DO  - 10.1016/j.eclinm.2023.102215
PY  - 2023///
TI  - Burden and risk factors of chronic obstructive pulmonary disease in Sub-Saharan African countries, 1990-2019: a systematic analysis for the Global Burden of disease study 2019.
T2  - EClinicalMedicine
UR  - http://dx.doi.org/10.1016/j.eclinm.2023.102215
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37799614
VL  - 64
ER  -
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