Publications
511 results found
Morris ES, McHayle A, Digesu A, et al., 2019, BLADDER BIOPSIES TAKEN USING A FLEXIBLE CYSTOSCOPE ARE NOT RELIABLE FORMAST CELL COUNTS, Publisher: SPRINGER LONDON LTD, Pages: S342-S343, ISSN: 0937-3462
Veit-Rubin N, De Tayrac R, Cartwright R, et al., 2019, Abnormal vaginal microbiome associated with vaginal mesh complications, Neurourology and Urodynamics, Vol: 38, Pages: 2255-2263, ISSN: 0733-2467
AimsTo identify differences in the vaginal microbiomes of women after transvaginal mesh (TVM) surgery for pelvic organ prolapse with and without mesh‐associated complications.MethodsPatients with complications were eligible as cases, patients without as controls. DNA was isolated and the V1‐2 region of the 16S ribosomal RNA gene was amplified and sequenced. Overall richness was quantified using Chao1. Overall diversity was expressed as Shannon diversity and screened for group differences using analysis of variance. Multivariate differences among groups were evaluated with functions from R .ResultsWe recruited 14 patients after mesh exposure, 5 after contraction, and 21 as controls. The average number of operational taxonomic unit was 74.79 (SD ± 63.91) for controls, 57.13 (SD ± 58.74) after exposures, and 92.42 (SD ± 50.01) after contractions. Total 89.6% of bacteria in controls, 86.4% in previous exposures, and 81.3% in contractions were classified as either Firmicutes, Proteobacteria , or Actinobacteria (P < .001). Veillonella spp. was more abundant in patients after contraction (P = .045). The individual microbiomes varied, and we did not detect any significant differences in richness but a trend towards higher diversity with complications.ConclusionsThe presence of Veillonella spp. could be associated with mesh contraction. Our study did not identify vaginal microbiotic dysbiosis as a factor associated with exposure. Larger cohort studies would be needed to distinguish the vaginal microbiome of women predisposed to mesh‐related complications for targeted phenotyping of patients who could benefit from TVM surgery.
Tailor V, McHayle A, Morris E, et al., 2019, PERINEOMETER AND DIGITAL EXAMINATION VARIATION WITH THE LEVATOR ANI HIATUS SIZE, 49th Annual Meeting of the International-Continence-Society (ICS), Publisher: WILEY, Pages: S48-S49, ISSN: 0733-2467
Ford AA, Taylor V, Ogah J, et al., 2019, Midurethral slings for treatment of stress urinary incontinence review, NEUROUROLOGY AND URODYNAMICS, Vol: 38, Pages: S70-S75, ISSN: 0733-2467
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- Citations: 17
Purwar B, Cartwright R, Cavalcanti G, et al., 2019, The impact of bariatric surgery on urinary incontinence: a systematic review and meta-analysis, INTERNATIONAL UROGYNECOLOGY JOURNAL, Vol: 30, Pages: 1225-1237, ISSN: 0937-3462
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- Citations: 6
Asfour V, Gibbs K, Franklin L, et al., 2019, Ultrasound technique for the assessment of urethral descent assessment technique (UDAT) in healthy volunteers, Journal of Obstetrics and Gynaecology, ISSN: 0144-3615
Bladder neck descent (BND) has been implicated in the pathophysiology of stress incontinence and prolapse. The aim of this study was to evaluate a novel 2D technique for the evaluation of BND, the Urethral Descent Assessment Technique (UDAT). UDAT involves measuring BND during dynamic manoeuvres in live 2D ultrasound, by using the geometrical properties of parallel lines. The internal urethral meatus and distal end of the urethra are used as reference points. Y1 is the urethral height at rest (also the urethral length when the urethra is straight). Y2 is the urethral height on Valsalva. Y1 and Y2 are parallel lines. Y1–Y2 = BND. A horizontal line (X) connecting Y1 and Y2 is the forward movement of the bladder neck.Y1 mean 30.4 mm (95% CI ± 1.36 mm). Y2 mean 24.2 mm (95% CI ± 2.58 mm). X mean 12.1 mm (95% CI ± 1.66 mm). BND mean 6.2 mm (95% CI ± 1.47 mm). Bland–Altman plots and linear regression showed that UDAT is repeatable and reliable.
Tailor V, Digesu A, Khullar V, et al., 2019, Results of a prospective, multicenter study evaluating impact of a wireless implantable tibial nerve stimulator at 3 years in subjects with overactive bladder symptoms (OAB), British Congress of the RCOG, Publisher: WILEY, Pages: 227-228, ISSN: 1470-0328
Bhide AA, Khullar V, Swift S, et al., 2019, The use of laser in urogynaecology, International Urogynecology Journal and Pelvic Floor Dysfunction, Vol: 30, Pages: 683-692, ISSN: 0937-3462
IntroductionThe use of lasers in urogynaecology has increased in recent years. Their use has been described in pelvic organ prolapse, urinary incontinence and genito-urinary symptoms of menopause. The aim of this study was to review the published literature on CO2 and erbium:YAG laser use in urogynaecological conditions.MethodsAn extensive search of literature databases (PubMed, EMBASE) was performed for publications (full text and abstracts) written in English up to July 2018. Relevant trials were selected and analysed by an independent reviewer. Twenty-five studies were identified in total.ResultsAll studies were either prospective cohort or case-control studies. The results of individual studies indicate that both CO2 and erbium lasers are effective in treating urogynaecological conditions. Most studies use a vaginal approach with only two investigations of intraurethral application.ConclusionThe use of lasers to treat these conditions may seem appealing; however, the lack of good-quality evidence in the form of multi-centre randomised placebo-controlled trials is concerning. The safety and effectiveness of these laser devices have not been established. Use of lasers may lead to serious adverse events such as vaginal burns, scarring, dyspareunia and chronic pain. Randomised placebo-controlled trials in addition to formal evaluation of the laser devices are required before this treatment modality can be recommended.
Serati M, Andersson K-E, Dmochowski R, et al., 2019, Systematic Review of Combination Drug Therapy for Non-neurogenic Lower Urinary Tract Symptoms, EUROPEAN UROLOGY, Vol: 75, Pages: 129-168, ISSN: 0302-2838
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- Citations: 15
Da Silva AS, Asfour V, Digesu GA, et al., 2019, Levator Ani avulsion: The histological composition of this site. A cadaveric study, NEUROUROLOGY AND URODYNAMICS, Vol: 38, Pages: 123-129, ISSN: 0733-2467
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- Citations: 3
Asfour V, Gargasole C, Fernando R, et al., 2018, Urodynamics are necessary for patients with asymptomatic pelvic organ prolapse, NEUROUROLOGY AND URODYNAMICS, Vol: 37, Pages: 2841-2846, ISSN: 0733-2467
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- Citations: 8
Wagg A, Darekar A, Arumi D, et al., 2018, Factors associated with dose escalation of fesoterodine for treatment of overactive bladder in people >65 years of age: A post hoc analysis of data from the SOFIA study (vol 34, pg 438, 2015), NEUROUROLOGY AND URODYNAMICS, Vol: 37, Pages: 2989-2989, ISSN: 0733-2467
Cartwright R, Jarvelin M, Miotla P, et al., 2018, Genome wide association study identifies two novel loci associated with female stress and urgency urinary incontinence, 50th European-Society-of-Human-Genetics (ESHG) Conference, Publisher: NATURE PUBLISHING GROUP, Pages: 93-93, ISSN: 1018-4813
Abrams P, Andersson K-E, Apostolidis A, et al., 2018, 6th International Consultation on Incontinence. Recommendations of the International Scientific Committee: EVALUATION AND TREATMENT OF URINARY INCONTINENCE, PELVIC ORGAN PROLAPSE AND FAECAL INCONTINENCE, NEUROUROLOGY AND URODYNAMICS, Vol: 37, Pages: 2271-2272, ISSN: 0733-2467
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- Citations: 136
Ford A, Asfour V, Tailor V, et al., 2018, Diamine oxidase and mast cell count; Two separate roles in the pathogenesis of bladder pain syndrome, International Urogynaecology Association Meeting, Publisher: SPRINGER LONDON LTD, Pages: S24-S24, ISSN: 0937-3462
Bhide A, Digesu A, Fernando R, et al., 2018, Evaluation of urinary symptoms and urodynamic abnormalities in HTLV-I infected individuals with associated myelopathy, International Urogynaecology Association Meeting, Publisher: SPRINGER LONDON LTD, Pages: S271-S271, ISSN: 0937-3462
Veit-Rubin N, De Tayrac R, Cartwright R, et al., 2018, The vaginal microbiome after transvaginal mesh complications: a case-control study, International Urogynaecology Association, Publisher: SPRINGER LONDON LTD, Pages: S17-S18, ISSN: 0937-3462
Bhide A, Digesu A, Fernando R, et al., 2018, Can urinary BDNF be a useful biomarker in lower urinary tract symptom assesment? A meta-analysis, International Urogynaecology Association Meeting, Publisher: SPRINGER LONDON LTD, Pages: S270-S271, ISSN: 0937-3462
Veit-Rubin N, Mahboobani KS, Cartwright R, et al., 2018, RELATIONSHIP BETWEEN THE URINARY, UROTHELIAL AND VAGINAL MICROBIOME IN OVERACTIVE BLADDER, Meeting of the International-Continence-Society (ICS), Publisher: WILEY, Pages: S41-S42, ISSN: 0733-2467
Averbeck MA, Rantell A, Ford A, et al., 2018, Current controversies in urinary tract infections: ICI-RS 2017, NEUROUROLOGY AND URODYNAMICS, Vol: 37, Pages: S86-S92, ISSN: 0733-2467
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- Citations: 12
Ford AA, Veit-Rubin N, Cardozo L, et al., 2018, Is the microbiome influencing patient care in lower urinary tract dysfunction? Report from the ICI-RS 2017, NEUROUROLOGY AND URODYNAMICS, Vol: 37, Pages: S93-S98, ISSN: 0733-2467
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- Citations: 3
Asfour V, Digesu GA, Ford A, et al., 2018, Re: Ultrasound bladder wall thickness and detrusor overactivity: a multicentre test accuracy study Is it fair to assess new imaging techniques against a poor gold standard?, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 125, Pages: 395-395, ISSN: 1470-0328
Bray R, Cartwright R, Cardozo L, et al., 2018, Tolterodine ER reduced increased bladder wall thickness in women with overactive bladder. A randomized, placebo-controlled, double-blind, parallel group study, NEUROUROLOGY AND URODYNAMICS, Vol: 37, Pages: 237-243, ISSN: 0733-2467
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- Citations: 7
Bray R, Cacciatore S, Jimenez B, et al., 2017, Urinary metabolic phenotyping of women with lower urinary tract symptoms, Journal of Proteome Research, Vol: 16, Pages: 4208-4216, ISSN: 1535-3893
Lower urinary tract symptoms (LUTS), including urinary incontinence, urgency and nocturia, affect approximately half of women worldwide. Current diagnostic methods for LUTS are invasive and costly, while available treatments are limited by side effects leading to poor patient compliance. In this study, we aimed to identify urine metabolic signatures associated with LUTS using proton nuclear magnetic resonance (1H NMR) spectroscopy. A total of 214 urine samples were collected from women attending tertiary urogynecology clinics (cases; n = 176) and healthy control women attending general gynecology clinics (n = 36). Despite high variation in the urine metabolome across the cohort, associations between urine metabolic profiles and BMI, parity, overactive bladder syndrome, frequency, straining, and bladder storage were identified using KODAMA (knowledge discovery by accuracy maximization). Four distinct urinary metabotypes were identified, one of which was associated with increased urinary frequency and low BMI. Urine from these patients was characterized by increased levels of isoleucine and decreased levels of hippurate. Our study suggests that metabolic profiling of urine samples from LUTS patients offers the potential to identify differences in underlying etiology, which may permit stratification of patient populations and the design of more personalized treatment strategies.
Latthe P, Middleton L, Rachaneni S, et al., 2017, Ultrasound bladder wall thickness and detrusor overactivity: a multicentre test accuracy study., BJOG, Vol: 124, Pages: 1422-1429
OBJECTIVE: Women with overactive bladder (OAB) often undergo urodynamics before invasive treatments are considered. Ultrasound measurement of bladder wall thickness (BWT) is a less invasive, less expensive and widely available test. It has the potential to diagnose the presence of detrusor overactivity (DO). We aimed to evaluate the accuracy of BWT in the diagnosis of DO. DESIGN: Prospective cohort study. SETTING: Twenty-two UK clinics (university and district general hospitals). METHODS: Consecutive eligible women with OAB symptoms had transvaginal ultrasound to estimate BWT (index test). The reference standard for the diagnosis of DO was urodynamic testing with multichannel subtracted cystometry. MAIN OUTCOME MEASURES: The sensitivity, specificity and likelihood ratios using a BWT threshold of ≥5 mm were used to indicate the presence of DO, and the area under the receiver operating characteristics (ROC) curve to give an overall estimate of BWT accuracy. RESULTS: Between March 2011 and 2013, 644/687 (94%) women recruited had both tests. The mean age was 52.7 years (standard deviation 13.9) and DO was diagnosed in 399/666 (60%) women. BWT had a sensitivity of 43% [95% confidence interval (CI) 38-48%], specificity of 62% (95% CI 55-68%), and likelihood ratios of 1.11 (95% CI 0.92-1.35) and 0.93 (95% CI 0.82-1.06) for positive and negative tests, respectively. The area under the ROC curve was 0.53 (95% CI 0.48-0.57). Extensive sensitivity analyses and subgroup analyses were carried out, but did not alter the interpretation. CONCLUSIONS: BWT is not a good replacement test for urodynamics in women with overactive bladder. TWEETABLE ABSTRACT: Bladder wall thickness is not a good replacement test for urodynamics in women with overactive bladder.
Da Silva AS, Asfour V, Digesu A, et al., 2017, A QUANTITATIVE HISTOLOGICAL EVALUATION OF THE PUBOVISCERAL ENTHESIS COMPARISON WITH OR WITH SONOGRAPHIC APPEARANCE OF LEVATOR ANI AVULSION., 47th Annual Meeting of the International-Continence-Society (ICS), Publisher: WILEY, Pages: S58-S59, ISSN: 0733-2467
Purwar B, Cartwright R, Cavalcanti G, et al., 2017, THE EFFECT OF BARIATRIC SURGERY ON URINARY INCONTINENCE: A SYSTEMATIC REVIEWAND META-ANALYSIS, International Urogynaecology Association Meeting, Publisher: SPRINGER LONDON LTD, Pages: S11-S12, ISSN: 0937-3462
Thiagamoorthy G, Bray R, Hunter JE, et al., 2017, A MULTICENTRE STUDY OF ETHNICITY AND DIAGNOSIS OF URINARY INCONTINENCE, International Urogynaecology Association Meeting, Publisher: SPRINGER LONDON LTD, Pages: S62-S63, ISSN: 0937-3462
Purwar B, Cartwright R, Ford AA, et al., 2017, IMPACT OF PELVIC ORGAN PROLAPSE ON THE SIZE OF UROGENITAL HIATUS - A COMPARATIVE STUDY OF WOMEN WITH AND WITHOUT PROLAPSE, International Urogynaecology Association Meeting, Publisher: SPRINGER LONDON LTD, Pages: S142-S142, ISSN: 0937-3462
Ford AA, Bray R, Asfour V, et al., 2017, OVERACTIVE BLADDER AND BLADDER PAIN SYNDROME; PAIN OF THE SAME SPECTRUM?, International Urogynaecology Association Meeting, Publisher: SPRINGER LONDON LTD, Pages: S65-S66, ISSN: 0937-3462
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