Publications
359 results found
Nijher GMK, Chaudhri OB, Ramachandran R, et al., 2010, The effects of kisspeptin-54 on blood pressure in humans and plasma kisspeptin concentrations in hypertensive diseases of pregnancy, BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Vol: 70, Pages: 674-681, ISSN: 0306-5251
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- Citations: 28
Gardiner JV, Beale KE, Roy D, et al., 2010, Cerebellin1 is a novel orexigenic peptide, DIABETES OBESITY & METABOLISM, Vol: 12, Pages: 883-890, ISSN: 1462-8902
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- Citations: 9
Ramachandran R, Bech P, Murphy KG, et al., 2010, Chromogranin A assays: Comparison of diagnostic accuracy, 18th International Symposium on Regulatory Peptides, Publisher: ELSEVIER SCIENCE BV, Pages: 12-12, ISSN: 0167-0115
Moolla A, Amin A, Ghaffar A, et al., 2010, The secretin test can be used to diagnose a gastrinoma even in patients who cannot stop proton pump inhibitors, 18th International Symposium on Regulatory Peptides, Publisher: ELSEVIER SCIENCE BV, Pages: 12-12, ISSN: 0167-0115
Tan T, Cabrita IZ, Hensman D, et al., 2010, Assessment of cardiac valve dysfunction in patients receiving cabergoline treatment for hyperprolactinaemia, CLINICAL ENDOCRINOLOGY, Vol: 73, Pages: 369-374, ISSN: 0300-0664
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- Citations: 35
Jayasena CN, Dhillo WS, 2010, Neurokinin B and Kisspeptin: Sexual Partners or Single Agents?, ENDOCRINOLOGY, Vol: 151, Pages: 4090-4091, ISSN: 0013-7227
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- Citations: 3
Tuah NAA, Qureshi S, Dhillo WS, et al., 2010, Development and application of the Imperial College Obesity Strategy Assessment Framework for analysing local obesity strategies, Primary Health Care Research & Development
Sam AH, Dhillo WS, 2010, Kisspeptin: A Critical Regulator of Puberty and Reproductive Function, CURRENT DRUG TARGETS, Vol: 11, Pages: 971-977, ISSN: 1389-4501
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- Citations: 5
Hrabovszky E, Ciofi P, Vida B, et al., 2010, The kisspeptin system of the human hypothalamus: sexual dimorphism and relationship with gonadotropin-releasing hormone and neurokinin B neurons, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 31, Pages: 1984-1998, ISSN: 0953-816X
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- Citations: 201
Curtis AE, Murphy KG, Chaudhri OB, et al., 2010, Kisspeptin is released from human prostate cancer cell lines but plasma kisspeptin is not elevated in patients with prostate cancer, ONCOLOGY REPORTS, Vol: 23, Pages: 1729-1734, ISSN: 1021-335X
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- Citations: 16
Nijher GMK, Baxter JE, Chaudhri OB, et al., 2010, Identification of the Hormone Kisspeptin in Amniotic Fluid, CLINICAL CHEMISTRY, Vol: 56, Pages: 1029-1031, ISSN: 0009-9147
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- Citations: 3
Salem V, Dhillo WS, Meeran K, et al., 2010, Dexamethasone-Suppressed Corticotrophin-Releasing Hormone-Stimulation Test Does Not Reliably Diagnose or Predict Recurrence of Cushing Disease, CLINICAL CHEMISTRY, Vol: 56, Pages: 1031-1034, ISSN: 0009-9147
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- Citations: 6
Jayasena CN, Nijher GMK, Abbara A, et al., 2010, Twice-Weekly Administration of Kisspeptin-54 for Eight Weeks Stimulates Reproductive Hormone Release in Women with Hypothalamic Amenorrhea, 92nd Meeting and Expo of the Endocrine Society (ENDO 2010), Publisher: ENDOCRINE SOC, Pages: S2527-S2527, ISSN: 0163-769X
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- Citations: 1
Jayasena CN, Nijher GMK, Chaudhri OB, et al., 2010, Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis, Obstetrical and Gynecological Survey, Vol: 65, Pages: 244-245, ISSN: 0029-7828
Corander MP, Challis BG, Thompson EL, et al., 2010, The Effects of Neurokinin B upon Gonadotrophin Release in Male Rodents, JOURNAL OF NEUROENDOCRINOLOGY, Vol: 22, Pages: 181-187, ISSN: 0953-8194
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- Citations: 56
Curtis AE, Murphy KG, Chaudhri OB, et al., 2010, Kisspeptin is released from human prostate cancer cell lines but plasma kisspeptin is not elevated in patients with prostate cancer, Oncology Reports, Vol: 23, Pages: 1729-1734, ISSN: 1021-335X
Kisspeptin, the product of the KiSS-1 gene, inhibits metastasis and stimulates the hypothalamo-pituitary-gonadal axis. Kisspeptin is therefore a putative target in the treatment of hormone-sensitive malignancies. Prostatic carcinoma remains a significant cause of mortality despite improvements in therapy. The role of kisspeptin in prostatic carcinoma remains undefined. We therefore aimed to investigate release of kisspeptin by prostatic cancer cell lines; investigate expression of KiSS-1 in human prostate tissue; investigate whether patients with prostate carcinoma have elevated plasma kisspeptin. 1) Culture medium from prostatic carcinoma cell lines LNCaP, DU145 and PC3 was assayed for kisspeptin immunoreactivity (-IR). Kisspeptin-IR release was detectable from all three cell lines. The effect of hydroxy-flutamide, gefitinib and resveratrol on kisspeptin-IR release from these cell lines was also investigated. No effect of the drugs tested on release of kisspeptin-IR was observed. 2) Expression of KiSS-1 in human prostate tissue (n=4) was investigated using in situ hybridisation. Expression of KiSS-1 was detected in human prostate tissue. 3) Plasma kisspeptin-IR was compared in 92 patients with prostatic carcinoma and 73 male controls. Kisspeptin-IR was not detected in the plasma of either patients with prostate cancer or control patients. We have therefore shown for the first time the release of kisspeptin-IR by prostatic carcinoma cell lines. We have also shown that KiSS-1 is expressed in human prostate tissue, and that circulating levels of kisspeptin-IR are not elevated in patients with prostatic carcinoma. Further work is required to determine the role of kisspeptin in the prostate.
Hameed S, Dhillo WS, 2010, Biology of Kisspeptins, KALLMANN SYNDROME AND HYPOGONADOTROPIC HYPOGONADISM, Vol: 39, Pages: 25-36, ISSN: 0301-3073
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- Citations: 7
Nijher GK, Dhillo WS, Bloom SR, 2009, Kisspeptin: A novel role in the regulation of reproductive function, Drug News and Perspectives, Vol: 22, Pages: 573-578, ISSN: 0214-0934
Kisspeptin appears to have a pivotal role in the regulation of reproductive function and may have a therapeutic role in the treatment of disorders of reproduction. In this review we summarise the evidence regarding kisspeptin and its function in the hypothalamic pituitary gonadal axis and also examine future therapeutic applications. Copyright © 2009 Prous Science, S.A.U. or its licensors. All rights reserved.
Nijher GK, Dhillo WS, Bloom SR, 2009, KISSPEPTIN: A NOVEL ROLE IN THE REGULATION OF REPRODUCTIVE FUNCTION, DRUG NEWS & PERSPECTIVES, Vol: 22, Pages: 573-578, ISSN: 0214-0934
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- Citations: 1
Ramachandran R, Benfield P, Dhillo WS, et al., 2009, Need for Revision of Diagnostic Limits for Medullary Thyroid Carcinoma with a New Immunochemiluminometric Calcitonin Assay, CLINICAL CHEMISTRY, Vol: 55, Pages: 2225-2226, ISSN: 0009-9147
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- Citations: 5
Gardiner JV, Bataveljic A, Patel NA, et al., 2009, Prokineticin 2 Is a Hypothalamic Neuropeptide That Potently Inhibits Food Intake, Diabetes, Vol: 59, Pages: 397-406, ISSN: 0012-1797
OBJECTIVE Prokineticin 2 (PK2) is a hypothalamic neuropeptide expressed in central nervous system areas known to be involved in food intake. We therefore hypothesized that PK2 plays a role in energy homeostasis.RESEARCH DESIGN AND METHODS We investigated the effect of nutritional status on hypothalamic PK2 expression and effects of PK2 on the regulation of food intake by intracerebroventricular (ICV) injection of PK2 and anti-PK2 antibody. Subsequently, we investigated the potential mechanism of action by determining sites of neuronal activation after ICV injection of PK2, the hypothalamic site of action of PK2, and interaction between PK2 and other hypothalamic neuropeptides regulating energy homeostasis. To investigate PK2's potential as a therapeutic target, we investigated the effect of chronic administration in lean and obese mice.RESULTS Hypothalamic PK2 expression was reduced by fasting. ICV administration of PK2 to rats potently inhibited food intake, whereas anti-PK2 antibody increased food intake, suggesting that PK2 is an anorectic neuropeptide. ICV administration of PK2 increased c-fos expression in proopiomelanocortin neurons of the arcuate nucleus (ARC) of the hypothalamus. In keeping with this, PK2 administration into the ARC reduced food intake and PK2 increased the release of α-melanocyte–stimulating hormone (α-MSH) from ex vivo hypothalamic explants. In addition, ICV coadministration of the α-MSH antagonist agouti-related peptide blocked the anorexigenic effects of PK2. Chronic peripheral administration of PK2 reduced food and body weight in lean and obese mice.CONCLUSIONS This is the first report showing that PK2 has a role in appetite regulation and its anorectic effect is mediated partly via the melanocortin system.
Jayasena CN, Nijher GMK, Chaudhri OB, et al., 2009, Subcutaneous Injection of Kisspeptin-54 Acutely Stimulates Gonadotropin Secretion in Women with Hypothalamic Amenorrhea, But Chronic Administration Causes Tachyphylaxis, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 94, Pages: 4315-4323, ISSN: 0021-972X
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- Citations: 150
Jayasena CN, Dhillo WS, 2009, Carcinoid syndrome, Medicine, Vol: 37, Pages: 454-456, ISSN: 1357-3039
Carcinoid tumours are the most common type of neuroendocrine tumour. However, fewer than 10% actually lead to carcinoid syndrome. Carcinoid tumours arise from enterochromaffin and enterochromaffin-like cells, which originate from the primitive gut. Classic symptoms of carcinoid syndrome, such as flushing and diarrhoea, occur as a consequence of the release of hormones, including serotonin, tachykinins and peptide hormones. In the majority of cases, liver metastasis has already occurred at the time of diagnosis. The diagnosis of carcinoid syndrome is made biochemically. Raised levels of a serotonin metabolite, 5-hydroxyindoleacetic acid, are detected during 24-hour urine collection. In addition, raised plasma chromogranin A is supportive of the diagnosis, but is not specific to carcinoid syndrome itself. Somatostatin analogue injections such as octreotide are the mainstay of carcinoid syndrome treatment. Simple therapies such as loperamide and antihistamines may also help to alleviate symptoms. Surgical debulking and hepatic embolization are useful methods to reduce tumour bulk in patients who remain symptomatic on medical treatment. Radioisotope therapy using radiolabelled octreotide or radiolabelled 5-hydroxytryptophan is becoming increasingly available, but is still used in only a minority of cases. A review of the pathophysiology and clinical features of carcinoid syndrome is provided and important issues in its management are highlighted. © 2009 Elsevier Ltd. All rights reserved.
Jayasena CN, Tharakan G, Dhillo WS, 2009, Kisspeptin: paving the way to a new therapeutic avenue in reproduction, Recent Patents on Endocrine, Metabolic & Immune Drug Discovery, Vol: 3, Pages: 87-93
Jayasena CN, Gadhvi KA, Gohel B, et al., 2009, Day 5 Morning Serum Cortisol Predicts Hypothalamic-Pituitary-Adrenal Function after Transsphenoidal Surgery for Pituitary Tumors, CLINICAL CHEMISTRY, Vol: 55, Pages: 972-977, ISSN: 0009-9147
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- Citations: 35
Jayasena CN, Dhillo WS, 2009, Kisspeptin offers a novel therapeutic target in reproduction, CURRENT OPINION IN INVESTIGATIONAL DRUGS, Vol: 10, Pages: 311-318, ISSN: 1472-4472
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- Citations: 12
Dhillo WS, Bewick GA, White NE, et al., 2009, The thyroid hormone derivative 3-iodothyronamine increases food intake in rodents, DIABETES OBESITY & METABOLISM, Vol: 11, Pages: 251-260, ISSN: 1462-8902
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- Citations: 39
Parkinson JRC, Chaudhri OB, Kuo Y-T, et al., 2009, Differential patterns of neuronal activation in the brainstem and hypothalamus following peripheral injection of GLP-1, oxyntomodulin and lithium chloride in mice detected by manganese-enhanced magnetic resonance imaging (MEMRI), NEUROIMAGE, Vol: 44, Pages: 1022-1031, ISSN: 1053-8119
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- Citations: 69
Thompson EL, Amber V, Stamp GWH, et al., 2009, Kisspeptin-54 at high doses acutely induces testicular degeneration in adult male rats via central mechanisms, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 156, Pages: 609-625, ISSN: 0007-1188
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- Citations: 43
Hameed S, Dhillo WS, Bloom SR, 2009, Gut hormones and appetite control, ORAL DISEASES, Vol: 15, Pages: 18-26, ISSN: 1354-523X
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- Citations: 66
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