Imperial College London
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ProfessorXiaodongZhang

Faculty of Medicine, Department of Infectious Disease

Professor of Macromolecular Structure and Function
 
 
 
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Contact

 

+44 (0)20 7594 3151xiaodong.zhang Website

 
 
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Assistant

 

Miss Kelly Butler +44 (0)20 7594 2763

 
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Location

 

104Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Uchiyama:2002:10.1083/jcb.200208112,
author = {Uchiyama, K and Jokitalo, E and Kano, F and Murata, M and Zhang, XD and Canas, B and Newman, R and Rabouille, C and Pappin, D and Freemont, P and Kondo, H},
doi = {10.1083/jcb.200208112},
journal = {Journal of Cell Biology},
pages = {855--866},
title = {VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo},
url = {http://dx.doi.org/10.1083/jcb.200208112},
volume = {159},
year = {2002}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - NSF and p97 are ATPases required for the heterotypic fusion of transport vesicles with their target membranes and the homotypic fusion of organelles. NSF uses ATP hydrolysis to dissociate NSF/SNAPs/SNAREs complexes, separating the v- and t-SNAREs, which are then primed for subsequent rounds of fusion. In contrast, p97 does not dissociate the p97/p47/SNARE complex even in the presence of ATP. Now we have identified a novel essential factor for p97/p47-mediated membrane fusion, named VCIP135 (valosin-containing protein [VCP][p97]/p47 complex-interacting protein, p135), and show that it binds to the p97/p47/syntaxin5 complex and dissociates it via p97 catalyzed ATP hydrolysis. In living cells, VCIP135 and p47 are shown to function in Golgi and ER assembly.
AU  - Uchiyama,K
AU  - Jokitalo,E
AU  - Kano,F
AU  - Murata,M
AU  - Zhang,XD
AU  - Canas,B
AU  - Newman,R
AU  - Rabouille,C
AU  - Pappin,D
AU  - Freemont,P
AU  - Kondo,H
DO  - 10.1083/jcb.200208112
EP  - 866
PY  - 2002///
SN  - 0021-9525
SP  - 855
TI  - VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo
T2  - Journal of Cell Biology
UR  - http://dx.doi.org/10.1083/jcb.200208112
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000179814700013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/69624
VL  - 159
ER  -
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