BibTex format
@article{Contreras:2023:10.1126/sciadv.adg3861,
author = {Contreras, MP and Pai, H and Selvaraj, M and Toghani, A and Lawson, DM and Tumtas, Y and Duggan, C and Yuen, ELH and Stevenson, CEM and Harant, A and Maqbool, A and Wu, C-H and Bozkurt, TO and Kamoun, S and Derevnina, L},
doi = {10.1126/sciadv.adg3861},
journal = {Science Advances},
title = {Resurrection of plant disease resistance proteins via helper NLR bioengineering},
url = {http://dx.doi.org/10.1126/sciadv.adg3861},
volume = {9},
year = {2023}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Parasites counteract host immunity by suppressing helper nucleotide binding and leucine-rich repeat (NLR) proteins that function as central nodes in immune receptor networks. Understanding the mechanisms of immunosuppression can lead to strategies for bioengineering disease resistance. Here, we show that a cyst nematode virulence effector binds and inhibits oligomerization of the helper NLR protein NRC2 by physically preventing intramolecular rearrangements required for activation. An amino acid polymorphism at the binding interface between NRC2 and the inhibitor is sufficient for this helper NLR to evade immune suppression, thereby restoring the activity of multiple disease resistance genes. This points to a potential strategy for resurrecting disease resistance in crop genomes.
AU - Contreras,MP
AU - Pai,H
AU - Selvaraj,M
AU - Toghani,A
AU - Lawson,DM
AU - Tumtas,Y
AU - Duggan,C
AU - Yuen,ELH
AU - Stevenson,CEM
AU - Harant,A
AU - Maqbool,A
AU - Wu,C-H
AU - Bozkurt,TO
AU - Kamoun,S
AU - Derevnina,L
DO - 10.1126/sciadv.adg3861
PY - 2023///
SN - 2375-2548
TI - Resurrection of plant disease resistance proteins via helper NLR bioengineering
T2 - Science Advances
UR - http://dx.doi.org/10.1126/sciadv.adg3861
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000988274400003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
VL - 9
ER -