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  • Journal article
    Wisden W, McNaughton LA, Darlison MG, Hunt SP, Barnard EAet al., 1989,

    Differential distribution of GABAA receptor mRNAs in bovine cerebellum--localization of alpha 2 mRNA in Bergmann glia layer

    , Neurosci Lett, Vol: 106, Pages: 7-12

    Using in situ hybridization histochemistry, we have demonstrated that 3 alpha subunit mRNAs of the GABAA receptor are present in different cell populations of the bovine cerebellum. While the alpha 1 mRNA is the most abundant and is present in granule cells, Purkinje cells and stellate/basket cells, the alpha 2 mRNA appears to be confined to the Bergmann glial cell layer. The alpha 3 mRNA is only expressed in the Golgi cells. This differential distribution of GABAA receptor mRNA subtypes suggests a previously unrecognized complexity of GABAergic transmission in the cerebellum.
  • Book chapter
    Wisden W, Morris BJ, Darlison MG, Hunt SP, Barnard EAet al., 1989,

    Differential distribution in bovine brain of distinct GABA-A receptor alpha subunit mRNAs.

    , Biochem Soc Trans (London), Pages: 566-567
  • Book chapter
    Darlison MG, Barnard EA, Bateson AN, Glencorse TA, Harvey RJ, Hicks AA, Hunt SP, Morris BJ, Vallejo M, Vreugdnhil E, Wisden Wet al., 1989,

    The structure and expression of the GABA-A receptor as deduced by molecular genetic studies.

    , In Molecular Biology of Neuroreceptors and Ion Channels, Editors: Maelicke, Publisher: Springer-Verlag, Heidelberg, Pages: 83-99
  • Journal article
    Morris BJ, Wisden W, Dunnett SB, Sirinathsinghji DJet al., 1989,

    Cellular localisation of somatostatin mRNA and neuropeptide Y mRNA in foetal striatal tissue grafts

    , Neurosci Lett, Vol: 103, Pages: 121-126, ISSN: 0304-3940

    Using in situ nucleic acid hybridisation histochemistry, we have studied the expression of somatostatin mRNA and neuropeptide Y mRNA in grafts of embryonic striatal neurones implanted into the ibotenic acid-lesioned rat neostriatum. Tissue sections of the grafted striatum were incubated with either 32P- or 35S-labelled complementary oligodeoxyribonucleotide probes specific for somatostatin mRNA and neuropeptide Y mRNA, exposed with X-ray film and dipped in Ilford K-5 emulsion. Neither somatostatin mRNA nor neuropeptide Y mRNA was detectable in the ibotenic acid-lesioned striatum indicating a pronounced degeneration of somatostatin- and neuropeptide Y-containing neurones. However, in the striatal grafts the levels of somatostatin mRNA and neuropeptide Y mRNA were substantially increased over those in the control intact striata. The results suggest that in the grafts, somatostatin mRNA and neuropeptide Y mRNA were expressed in a higher proportion of primordial striatal neurones and there was also an increased level of expression of each neuropeptide gene per individual neurone (reflecting a higher synthetic activity of such neurones) compared to the intact mature striatum. These data demonstrate the sensitivity of the in situ hybridisation technique to study patterns of gene expression in developing neuronal tissues after transplantation.
  • Journal article
    RK Poole, HD Williams, JA Downie, F Gibsonet al., 1989,

    Mutations affecting the cytochrome d-containing oxidase complex of Escherichia coli K12: Identification and mapping of a fourth locus, cydD

    , Journal of General Microbiology, Vol: 135, Pages: 1865-1874
  • Journal article
    Wisden W, Morris BJ, Darlison MG, Hunt SP, Barnard EAet al., 1989,

    Localization of GABA-A receptor alpha-subunit mRNAs in relation to receptor subtypes

    , Brain Res Mol Brain Res, Vol: 5, Pages: 305-310, ISSN: 0169-328X

    The distribution of 3 GABAA receptor alpha-subunit mRNAs in various regions of bovine brain has been investigated using in situ hybridization. Whereas the alpha 2- and alpha 3-transcripts are of low abundance in all regions except striatum, the alpha 1-transcript is considerably enriched in the inferior colliculus, olfactory bulb and substantia nigra, and appears to be correlated with benzodiazepine type I receptor localization.
  • Journal article
    CHAPMAN DJ, GOUNARIS K, BARBER J, 1989,

    THE D1[D2] CYTOCHROME-B559 PHOTOSYSTEM 2 REACTION CENTER FROM PISUM-SATIVUM-L - ISOLATION, CHARACTERIZATION AND DAMAGE BY LIGHT

    , PHOTOSYNTHETICA, Vol: 23, Pages: 411-426, ISSN: 0300-3604
  • Journal article
    RI Scott, RK Poole, HD Williams, 1989,

    The electron transport chain of Streptomyces erythreus: Possible functions of cytochrome aa3 and a novel green pigment.

    , Current Microbiology, Vol: 18, Pages: 297-302
  • Conference paper
    BOUSSAC A, RUTHERFORD AW, 1989,

    THE ROLE OF CA-2+ IN PHOTOSYSTEM-2

    , 3RD WORKSHOP ON PHOTOCHEMICAL, PHOTOELECTROCHEMICAL AND PHOTOBIOLOGICAL RESEARCH AND DEVELOPMENT : PHOTOCONVERSION PROCESSES FOR ENERGY AND CHEMICALS, Publisher: ELSEVIER APPL SCI PUBL LTD, Pages: 185-189
  • Journal article
    M Soberon, HD Williams, RK Poole, E Escamilaet al., 1989,

    Isolation of a Rhizobium phaseoli cytochrome mutant with enhanced respiration and symbiotic nitrogen-fixation

    , Journal of Bacteriology, Vol: 171, Pages: 465-472
  • Conference paper
    SPANU P, BOLLER T, 1989,

    ETHYLENE BIOSYNTHESIS IN TOMATO INFECTED BY PHYTOPHTHORA-INFESTANS

    , CONF ON BIOCHEMICAL AND PHYSIOLOGICAL ASPECTS OF ETHYLENE PRODUCTION IN LOWER AND HIGHER PLANTS, Publisher: KLUWER ACADEMIC PUBL, Pages: 255-260
  • Journal article
    Rothberg JM, Hartley DA, Walther Z, Artavanis-Tsakonas Set al., 1988,

    slit: an EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system.

    , Cell, Vol: 55, Pages: 1047-1059, ISSN: 0092-8674

    A family of loci homologous to the EGF-like portion of Notch, a gene involved in neurogenesis, have been identified in D. melanogaster. The sequence, spatial, and temporal distribution of both RNA and protein of one of these loci suggest a possible role in the development of the central nervous system (CNS). In situ hybridization and antibody staining of embryos show initial localization in cells along the midline of the neuroepithelium. High level expression is restricted in the developing embryo to a subset of six midline glial cells abutting growing axons. Extracellular localization is suggested by the presence of EGF-like repeats in the deduced protein sequence and antibody staining. Cytological, immunocytochemical, genetic, and molecular data show that this gene corresponds to the slit locus. Mutations in this locus result in the collapse of the regular scaffold of commissural and longitudinal axon tracts in the embryonic central nervous system.
  • Journal article
    ERDJUMENT H, LANE DA, IRELAND H, DIMARZO V, PANICO M, MORRIS HR, TRIPODI A, MANNUCCI PMet al., 1988,

    ANTITHROMBIN MILANO, SINGLE AMINO-ACID SUBSTITUTION AT THE REACTIVE SITE, ARG393 TO CYS

    , THROMBOSIS AND HAEMOSTASIS, Vol: 60, Pages: 471-475, ISSN: 0340-6245
  • Journal article
    ZVELEBIL M, STERNBERG MJE, COOKSON J, COATES ARMet al., 1988,

    PREDICTIONS OF LINEAR T-CELL AND B-CELL EPITOPES IN PROTEINS ENCODED BY HIV-1, HIV-2 AND SIVMAC AND THE CONSERVATION OF THESE SITES BETWEEN STRAINS

    , FEBS LETTERS, Vol: 242, Pages: 9-21, ISSN: 0014-5793
  • Journal article
    Hartley DA, Preiss A, Artavanis-Tsakonas S, 1988,

    A deduced gene product from the Drosophila neurogenic locus, enhancer of split, shows homology to mammalian G-protein beta subunit.

    , Cell, Vol: 55, Pages: 785-795, ISSN: 0092-8674

    The correct segregation of neural from epidermal lineages in Drosophila embryogenesis depends on the activity of the six zygotic "neurogenic" genes. One of the neurogenic genes, Enhancer of split, is particularly noteworthy in its genetic interactions with Notch and Delta, which both appear to code for transmembrane proteins with homology to the epidermal growth factor. Transformation experiments have demonstrated the cloning of sequences necessary for Enhancer of split gene function. We report here that the gene product derived from DNA sequencing shows homology to the beta subunit of mammalian G proteins and CDC4, a yeast cell cycle gene. We demonstrate that expression of the transcripts relates to the developing central nervous system. These data suggest a mechanism of interaction between the gene products of Notch and Enhancer of split.
  • Journal article
    PRENTICE IC, 1988,

    PALEOECOLOGY AND PLANT-POPULATION DYNAMICS

    , TRENDS IN ECOLOGY & EVOLUTION, Vol: 3, Pages: 343-345, ISSN: 0169-5347
  • Journal article
    BARTON GJ, STERNBERG MJE, 1988,

    LOPAL AND SCAMP - TECHNIQUES FOR THE COMPARISON AND DISPLAY OF PROTEIN STRUCTURES

    , JOURNAL OF MOLECULAR GRAPHICS, Vol: 6, Pages: 190-&, ISSN: 0263-7855
  • Journal article
    GOUNARIS K, CHAPMAN DJ, BARBER J, 1988,

    RECONSTITUTION OF PLASTOQUINONE IN THE D1 D2 CYTOCHROME-B-559 PHOTOSYSTEM-II REACTION CENTER COMPLEX

    , FEBS LETTERS, Vol: 240, Pages: 143-147, ISSN: 0014-5793
  • Journal article
    MASENTO MS, MORRIS HR, TAYLOR GW, JOHNSON SJ, SKAPSKI AC, KAY RRet al., 1988,

    DIFFERENTIATION-INDUCING FACTOR FROM THE SLIME-MOLD DICTYOSTELIUM-DISCOIDEUM AND ITS ANALOGS - SYNTHESIS, STRUCTURE AND BIOLOGICAL-ACTIVITY

    , BIOCHEMICAL JOURNAL, Vol: 256, Pages: 23-28, ISSN: 0264-6021
  • Journal article
    VOGLER AP, BROEKHUIZEN CP, SCHUITEMA A, LENGELER JW, POSTMA PWet al., 1988,

    SUPPRESSION OF IIIGLC-DEFECTS BY ENZYMES IINAG AND IIBGL OF THE PEP - CARBOHYDRATE PHOSPHOTRANSFERASE SYSTEM

    , MOLECULAR MICROBIOLOGY, Vol: 2, Pages: 719-726, ISSN: 0950-382X
  • Journal article
    VERMAAS WFJ, RUTHERFORD AW, HANSSON O, 1988,

    SITE-DIRECTED MUTAGENESIS IN PHOTOSYSTEM-II OF THE CYANOBACTERIUM SYNECHOCYSTIS SP PCC-6803 - DONOR-D IS A TYROSINE RESIDUE IN THE D2-PROTEIN

    , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 85, Pages: 8477-8481, ISSN: 0027-8424
  • Journal article
    , 1988,

    A protein sequence/structure database. Protein Engineering Club Database Group.

    , Nature, Vol: 335, Pages: 745-746, ISSN: 0028-0836

    Researchers have been wishing for years for a database integrating protein sequences and protein structures. A group from the United Kingdom has achieved this long-sought objective.
  • Journal article
    GREER FM, MORRIS HR, FORSTROM J, LYONS Det al., 1988,

    FAST ATOM BOMBARDMENT MASS-SPECTRAL SEARCH FOR THE AMINO TERMINUS OF GENETICALLY ENGINEERED ALPHA-1-ANTITRYPSIN

    , BIOMEDICAL AND ENVIRONMENTAL MASS SPECTROMETRY, Vol: 16, Pages: 191-195, ISSN: 0887-6134
  • Journal article
    MASENTO MS, MORRIS HR, TAYLOR GW, KAY RRet al., 1988,

    MORPHOGENS FROM DICTYOSTELIUM-DISCOIDEUM

    , BIOMEDICAL AND ENVIRONMENTAL MASS SPECTROMETRY, Vol: 16, Pages: 353-355, ISSN: 0887-6134
  • Journal article
    CERVONE F, CASTORIA R, SPANU P, BONFANTEFASOLO Pet al., 1988,

    PECTINOLYTIC ACTIVITY IN SOME ERICOID MYCORRHIZAL FUNGI

    , TRANSACTIONS OF THE BRITISH MYCOLOGICAL SOCIETY, Vol: 91, Pages: 537-539, ISSN: 0007-1536
  • Journal article
    DOMIN J, CONLON JM, DIMARZO V, THIM L, MORRIS HR, BLOOM SRet al., 1988,

    THE PURIFICATION AND SEQUENCE-ANALYSIS OF RAT NEUROMEDIN-U

    , REGULATORY PEPTIDES, Vol: 22, Pages: 400-400, ISSN: 0167-0115
  • Journal article
    CONLON JM, DOMIN J, THIM L, DIMARZO V, MORRIS HR, BLOOM SRet al., 1988,

    PRIMARY STRUCTURE OF NEUROMEDIN-U FROM THE RAT

    , JOURNAL OF NEUROCHEMISTRY, Vol: 51, Pages: 988-991, ISSN: 0022-3042
  • Journal article
    BURT A, HUNTE W, DUFRESNE F, 1988,

    IDENTIFYING THE TIME SCALE OF TEMPORAL ASSOCIATION

    , CANADIAN JOURNAL OF ZOOLOGY-REVUE CANADIENNE DE ZOOLOGIE, Vol: 66, Pages: 2090-2092, ISSN: 0008-4301
  • Journal article
    REES MCP, DIMARZO V, BERNAL AL, TIPPINS JR, MORRIS HR, TURNBULL ACet al., 1988,

    LEUKOTRIENE RELEASE BY HUMAN-FETAL MEMBRANES, PLACENTA AND DECIDUA IN RELATION TO PARTURITION

    , JOURNAL OF ENDOCRINOLOGY, Vol: 118, Pages: 497-500, ISSN: 0022-0795
  • Journal article
    BOUSSAC A, RUTHERFORD AW, 1988,

    CA-2+ BINDING TO THE OXYGEN EVOLVING ENZYME VARIES WITH THE REDOX STATE OF THE MN CLUSTER

    , FEBS LETTERS, Vol: 236, Pages: 432-436, ISSN: 0014-5793

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