Imperial College London

Professor Dan Elson

Faculty of MedicineDepartment of Surgery & Cancer

Professor of Surgical Imaging
 
 
 
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Contact

 

+44 (0)20 7594 1700daniel.elson Website

 
 
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Location

 

415 Bessemer BuildingBessemer BuildingSouth Kensington Campus

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Summary

 

Summary

Daniel Elson is a Professor of Surgical Imaging and Biophotonics in the Hamlyn Centre for Robotic Surgery, Institute of Global Health Innovation and Department of Surgery and Cancer at St. Mary's Hospital.  Research interests are based around the development and application of photonics technology to medical imaging, including multispectral imaging, ultrasound mediated optical tomography, structured lighting, light sources in endoscopy and scattering spectroscopy.

Also see my research webpage:

http://ubimon.doc.ic.ac.uk/elsonds/m657.html

Publications can be found on Google Scholar.

Recent publications are available here.

A list of current and previous lab members can also be found on my research webpage.

Image Guided Therapies


PhD Studentship

Hyperspectral circumferential resection margin assessment for gastrointestinal cancer surgery

Supervisors- Christopher Peters and Dan Elson

Multispectral optical probes promise sensitivity and specificity above 90% for discriminating between normal and abnormal tissue. One of these techniques, diffuse reflectance spectroscopy (DRS), utilises a safe broadband light source, optical fibres for light delivery and collection, a spectrograph to disperse the emitted light into the different wavelengths, and a detector (commonly a CCD camera). When compared to sophisticated microendoscopic probes, DRS has lower costs, and is simpler because it does not require lasers or magnification optics. Furthermore, combining DRS with fluorescence spectroscopy can offer increased accuracy through a dual modality approach that nevertheless maintains a simple probe design for clinical deployment.

We propose the use of a miniaturised endoscopic 2-D array of single-point DRS probe sensors for hyperspectral CRM assessment, based on technology developed in the Elson group. Such a device could be used directly in the surgical field, allowing the discrimination of tumour from scar tissue in real-time, minimising the time and cost of the CRM assessment, and optimising the clinical outcomes for patients with GI cancer. Furthermore, we propose to adapt this approach to transform it from a single point spectroscopic method to an imaging device that is suitable for in vivo data acquisition.

Aim of this study

Is it possible to analyse intraoperative circumferential resection margins by using hyperspectral probes for automated tissue classification?

All enquiries to daniel.elson@imperial.ac.uk 

Selected Publications

Journal Articles

Lin J, Clancy NT, Qi J, et al., 2018, Dual-modality endoscopic probe for tissue surface shape reconstruction and hyperspectral imaging enabled by deep neural networks, Medical Image Analysis, Vol:48, ISSN:1361-8415, Pages:162-176

Qi J, He H, Lin J, et al., 2018, Assessment of tissue polarimetric properties using Stokes polarimetric imaging with circularly polarized illumination, Journal of Biophotonics, Vol:11, ISSN:1864-063X

Qi J, He C, Elson DS, 2017, Real time complete Stokes polarimetric imager based on a linear polarizer array camera for tissue polarimetric imaging, Biomedical Optics Express, Vol:8, ISSN:2156-7085, Pages:4933-4946

Gallina ME, Zhou Y, Johnson CJ, et al., 2016, Aptamer-conjugated, fluorescent gold nanorods as potential cancer theradiagnostic agents, Materials Science & Engineering C - Biomimetic and Supramolecular Systems, Vol:59, ISSN:0928-4931, Pages:324-332

Singh M, Harris-Birtill DCC, Markar SR, et al., 2015, Application of gold nanoparticles for gastrointestinal cancer theranostics: A systematic review, Nanomedicine-Nanotechnology Biology and Medicine, Vol:11, ISSN:1549-9634, Pages:2083-2098

Clancy NT, Arya S, Stoyanov D, et al., 2015, Intraoperative measurement of bowel oxygen saturation using a multispectral imaging laparoscope, Biomedical Optics Express, Vol:6, ISSN:2156-7085, Pages:4179-4190

Li S, Cheng Y, Eckersley RJ, et al., 2015, Dual shear wave induced laser speckle contrast signal and the improvement in shear wave speed measurement, Biomedical Optics Express, Vol:6, ISSN:2156-7085, Pages:1954-1962

More Publications