Daniel Elson is a Professor of Surgical Imaging and Biophotonics in the Hamlyn Centre for Robotic Surgery, Institute of Global Health Innovation and Department of Surgery and Cancer at St. Mary's Hospital. Research interests are based around the development and application of photonics technology to medical imaging, including multispectral imaging, ultrasound mediated optical tomography, structured lighting, light sources in endoscopy and scattering spectroscopy.
Also see my research webpage:
Publications can be found on Google Scholar.
Recent publications are available here.
A list of current and previous lab members can also be found on my research webpage.
Hyperspectral circumferential resection margin assessment for gastrointestinal cancer surgery
Supervisors- Christopher Peters and Dan Elson
Multispectral optical probes promise sensitivity and specificity above 90% for discriminating between normal and abnormal tissue. One of these techniques, diffuse reflectance spectroscopy (DRS), utilises a safe broadband light source, optical fibres for light delivery and collection, a spectrograph to disperse the emitted light into the different wavelengths, and a detector (commonly a CCD camera). When compared to sophisticated microendoscopic probes, DRS has lower costs, and is simpler because it does not require lasers or magnification optics. Furthermore, combining DRS with fluorescence spectroscopy can offer increased accuracy through a dual modality approach that nevertheless maintains a simple probe design for clinical deployment.
We propose the use of a miniaturised endoscopic 2-D array of single-point DRS probe sensors for hyperspectral CRM assessment, based on technology developed in the Elson group. Such a device could be used directly in the surgical field, allowing the discrimination of tumour from scar tissue in real-time, minimising the time and cost of the CRM assessment, and optimising the clinical outcomes for patients with GI cancer. Furthermore, we propose to adapt this approach to transform it from a single point spectroscopic method to an imaging device that is suitable for in vivo data acquisition.
Aim of this study
Is it possible to analyse intraoperative circumferential resection margins by using hyperspectral probes for automated tissue classification?
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et al., 2018, Dual-modality endoscopic probe for tissue surface shape reconstruction and hyperspectral imaging enabled by deep neural networks, Medical Image Analysis, Vol:48, ISSN:1361-8415, Pages:162-176
et al., 2018, Assessment of tissue polarimetric properties using Stokes polarimetric imaging with circularly polarized illumination, Journal of Biophotonics, Vol:11, ISSN:1864-063X
Qi J, He C, Elson DS, 2017, Real time complete Stokes polarimetric imager based on a linear polarizer array camera for tissue polarimetric imaging, Biomedical Optics Express, Vol:8, ISSN:2156-7085, Pages:4933-4946
et al., 2016, Aptamer-conjugated, fluorescent gold nanorods as potential cancer theradiagnostic agents, Materials Science & Engineering C - Biomimetic and Supramolecular Systems, Vol:59, ISSN:0928-4931, Pages:324-332
et al., 2015, Application of gold nanoparticles for gastrointestinal cancer theranostics: A systematic review, Nanomedicine-Nanotechnology Biology and Medicine, Vol:11, ISSN:1549-9634, Pages:2083-2098
et al., 2015, Intraoperative measurement of bowel oxygen saturation using a multispectral imaging laparoscope, Biomedical Optics Express, Vol:6, ISSN:2156-7085, Pages:4179-4190
et al., 2015, Dual shear wave induced laser speckle contrast signal and the improvement in shear wave speed measurement, Biomedical Optics Express, Vol:6, ISSN:2156-7085, Pages:1954-1962