Imperial College London
Alternate

Professor Daniel Elson

Faculty of Medicine, Department of Surgery & Cancer

Professor of Surgical Imaging
 
 
 
//

Contact

 

+44 (0)20 7594 1700daniel.elson Website CV

 
 
//

Location

 

415 Bessemer BuildingBessemer BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@inproceedings{Perrott:2021:bjs/znab259.803,
author = {Perrott, C and Patil, A and Elson, D and Peters, C},
doi = {bjs/znab259.803},
pages = {1--1},
publisher = {British Journal of Surgery Society},
title = {Novel methods of detecting tumour margins in gastrointestinal cancer surgery},
url = {http://dx.doi.org/10.1093/bjs/znab259.803},
year = {2021}
}
Download

RIS format (EndNote, RefMan)

TY  - CPAPER
AB  - AimGastrointestinal (GI) cancers account for 26% of global cancer incidence with prevalence projected to rise exponentially due to the ageing population and lifestyle choices. Surgical resection is the mainstay of treatment to remove the cancer in its entirety to achieve an R0 resection. Positive margins, when cancerous tissue has been left in situ, is associated with increased morbidity and mortality. Current margin assessment involves histopathological analysis, after resection of the specimen. Diffuse Reflectance Spectroscopy (DRS) and Hyperspectral Imaging (HSI) are novel imaging techniques that have the potential to provide real-time assessment of cancer margins intra-operatively to reduce the incidence of positive resection margins and improve patient outcomes. The aim of this review is to assess the current state of evidence for the use of novel imaging techniques in GI cancer margin assessment.MethodA literature review was conducted of studies using DRS and HSI in GI cancers in adult patients, published from inception to October 2020.ResultsA total of 15 studies were analysed, nine of which used DRS and six used HSI and the majority of studies were performed ex-vivo. Current image acquisition techniques and processing algorithms vary greatly. The sensitivity and specificity of DRS ranged from 0.90-0.98 and 0.88-0.95 respectively and for HSI 0.63-0.98 and 0.69-0.98, respectively across five types of GI cancers.ConclusionsDRS and HSI are novel imaging techniques, currently in their infancy but the outlook is promising. With further research focused on standardising methodology and in-vivo settings, DRS and HSI could transform intra-operative margin assessment in GI cancers.
AU  - Perrott,C
AU  - Patil,A
AU  - Elson,D
AU  - Peters,C
DO  - bjs/znab259.803
EP  - 1
PB  - British Journal of Surgery Society
PY  - 2021///
SN  - 0007-1323
SP  - 1
TI  - Novel methods of detecting tumour margins in gastrointestinal cancer surgery
UR  - http://dx.doi.org/10.1093/bjs/znab259.803
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000711212701244&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://academic.oup.com/bjs/article/108/Supplement_6/znab259.803/6388584?searchresult=1
UR  - http://hdl.handle.net/10044/1/94033
ER  -
Download