Imperial College London

MrJosephShalhoub

Faculty of MedicineDepartment of Surgery & Cancer

Honorary Clinical Lecturer
 
 
 
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Contact

 

j.shalhoub Website

 
 
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Location

 

Charing Cross HospitalCharing Cross Campus

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Summary

 

Summary

BSc MBBS FHEA PhD MEd FRCS FEBVS

Honorary Clinical Lecturer
Academic Section of Vascular Surgery
Division of Surgery
Department of Surgery & Cancer
Faculty of Medicine
Imperial College London

Research Areas of Focus

  • Vascular & Endovascular Surgery
  • Arterial Disease, including Peripheral Arterial Disease and Carotid Disease
  • Venous Disease
  • Thrombosis
  • Clinical Trials

Co-Investigator: Examining the benefit of graduated compression stockings as an adjunct to low dose low molecular weight heparin in the prevention of venous thromboembolism in elective surgical inpatients identified as moderate or high risk for venous thromboembolism – a multi-centre randomised controlled trial (NIHR HTA GAPS Trial)
https://www.journalslibrary.nihr.ac.uk/programmes/hta/1414061/
https://w3.abdn.ac.uk/hsru/GAPS/

Co-Investigator: Does Neuromuscular Electrical Stimulation improve the absolute walking distance in patients with Intermittent Claudication compared to best available treatment? a multicentre randomised controlled study (NIHR / MRC EME NESIC Trial)
https://www.journalslibrary.nihr.ac.uk/programmes/eme/1518068/
http://www.imperial.ac.uk/department-surgery-cancer/research/surgery/clinical-trials/nesic/

  • Vascular Biology
  • Metabolic Profiling in Vascular Disease
  • Vascular Imaging
  • Surgical Education and Training
  • Big Data

Clinical Need For risk stratification in atherosclerotic carotid stenosis

Stroke is a major cause of death, disability and dependence; these strokes are potentially preventable. A carotid atherosclerosis is responsible for significant proportion of strokes, with the identification of those carotid stenoses which are likely to be responsible for future neurological events identified as an important unmet clinical need.

Summary of Research Focus For risk stratification in atherosclerotic carotid stenosis

Molecular characterisation of high-risk carotid atherosclerosis using:

  • Plaque cell culture and multi-analyte profiling
  • 'Omics' technologies, including metabolic profiling, lipidomics, proteomics and transcriptomics
  • Immunohistochemistry

Identification of vulnerable carotid stenosis through novel imaging:

  • Contrast-enhanced ultrasound
  • PET/CT

Assessment of putative candidate biomarkers of atherosclerosis burden and instability. 

 Histological section of an atherosclerotic carotid plaque, stained for the macrophage marker CD68 

Image: Histological section of an atherosclerotic carotid plaque, stained for the macrophage marker CD68

Collaborations

Sources of Funding

  • Co-Investigator, National Institute for Health Research Health Technology Assessment (NIHR HTA) Project Grant 14/140/61
  • Co-Investigator, National Institute for Health Research Health Technology Assessment / Medical Research Council Efficacy and Mechanism Evaluation (NIHR / MRC EME) Project Grant 15/180/68
  • Royal College of Surgeons of England
  • Circulation Foundation
  • Stroke Association
  • Rosetrees Trust
  • Graham-Dixon Charitable Trust
  • Peel Medical Research Trust

Publications

Journals

Humm G, Harries RL, Derbyshire LF, et al., Teaching ‘Foundation Skills in Surgery’: Evaluating the Association of Surgeons in Training Course, Bulletin of the Royal College of Surgeons of England, ISSN:1473-6357

Nepogodiev D, Chapman SJ, Kolias AG, et al., The impact of trainee research collaboratives in the UK, Lancet Gastroenterology and Hepatology, ISSN:2468-1253

Nepogodiev D, National Surgical Research Collaborative, Shalhoub J, UK surgical trainees will continue to support European research collaboration, The Lancet, ISSN:0140-6736

Stather P, Mascara F, on Behalf of the Vascular and Endovascular Research Network (VERN), Cardiovascular Risk Reduction in Referrals to Outpatient Vascular Clinic (CaRdiOVasC Study), Annals of the Royal College of Surgeons of England, ISSN:0035-8843

Conference

Albazde O, Shalhoub J, Davies A, 2017, The effect of supervised exercise on biomarker levels in individuals with peripheral arterial disease - a systematic review, International Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland, WILEY, Pages:82-82, ISSN:0007-1323

More Publications