Imperial College London

MrJosephShalhoub

Faculty of MedicineDepartment of Surgery & Cancer

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

j.shalhoub Website

 
 
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Location

 

Charing Cross HospitalCharing Cross Campus

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Summary

 

Summary

BSc MBBS FHEA PhD MEd FRCS FEBVS

Consultant Vascular Surgeon
Imperial College Healthcare NHS Trust

Honorary Clinical Senior Lecturer
Academic Section of Vascular Surgery
Division of Surgery
Department of Surgery & Cancer
Faculty of Medicine
Imperial College London


Mr Joseph Shalhoub is a Consultant Vascular Surgeon appointed at Imperial College Healthcare NHS Trust, St Mary’s Hospital and Charing Cross Hospital. He qualified with honours from Imperial College School of Medicine, completing his postgraduate surgical training in London including St Mary’s Hospital, Charing Cross Hospital, and St Thomas’ Hospital. Mr Shalhoub is a Fellow of the Royal College of Surgeons of England (FRCS), and was awarded the Gold Medal for the highest mark in the Fellowship of the European Board of Vascular Surgery (FEBVS) examination. After receiving his Certificate of Completion of Training (CCT) and gaining entry onto the General Medical Council (GMC) Specialist Register, he undertook a post-CCT Senior Clinical Fellowship in Vascular and Endovascular Surgery at St Thomas’ Hospital, London.

Mr Shalhoub has a strong academic and educational background which compliments his evidence-based clinical practice. He is an Honorary Clinical Senior Lecturer in the Department of Surgery and Cancer, Imperial College London where he is co-investigator for two National Institute for Health Research (NIHR) government-funded large multi-centre randomised clinical trials:

Co-Investigator: Examining the benefit of graduated compression stockings as an adjunct to low dose low molecular weight heparin in the prevention of venous thromboembolism in elective surgical inpatients identified as moderate or high risk for venous thromboembolism – a multi-centre randomised controlled trial (NIHR HTA GAPS Trial)
https://www.journalslibrary.nihr.ac.uk/programmes/hta/1414061/
https://w3.abdn.ac.uk/hsru/GAPS/

Co-Investigator: Does Neuromuscular Electrical Stimulation improve the absolute walking distance in patients with Intermittent Claudication compared to best available treatment? a multicentre randomised controlled study (NIHR / MRC EME NESIC Trial)
https://www.journalslibrary.nihr.ac.uk/programmes/eme/1518068/
http://www.imperial.ac.uk/department-surgery-cancer/research/surgery/clinical-trials/nesic/

He completed his BSc, PhD and Masters in Education (MEd) all at Imperial College London, receiving Research Fellowships from the Royal College of Surgeons of England and the Circulation Foundation. To date, he has secured more than £3.2 million in research funding as principal applicant or co-applicant, and has published more than 130 Pubmed indexed articles.

Mr Shalhoub is a Fellow of the Higher Education Academy (FHEA), Member of the Faculty of Surgical Trainers of the Royal College of Surgeons of Edinburgh (MFSTEd), Council Member and past Honorary Secretary of the Surgery Section of the Royal Society of Medicine (RSM), and Committee Member of the Vascular and Endovascular Research Network (VERN). He was a Council Member and past Vice-President of the Association of Surgeons in Training (ASiT).




Research Areas of Focus

  • Vascular & Endovascular Surgery
  • Arterial Disease, including Peripheral Arterial Disease and Carotid Disease
  • Venous Disease
  • Thrombosis
  • Clinical Trials
  • Vascular Biology
  • Metabolic Profiling in Vascular Disease
  • Vascular Imaging
  • Surgical Education and Training
  • Big Data

Clinical Need For risk stratification in atherosclerotic carotid stenosis

Stroke is a major cause of death, disability and dependence; these strokes are potentially preventable. A carotid atherosclerosis is responsible for significant proportion of strokes, with the identification of those carotid stenoses which are likely to be responsible for future neurological events identified as an important unmet clinical need.

Summary of Research Focus For risk stratification in atherosclerotic carotid stenosis

Molecular characterisation of high-risk carotid atherosclerosis using:

  • Plaque cell culture and multi-analyte profiling
  • 'Omics' technologies, including metabolic profiling, lipidomics, proteomics and transcriptomics
  • Immunohistochemistry

Identification of vulnerable carotid stenosis through novel imaging:

  • Contrast-enhanced ultrasound
  • PET/CT

Assessment of putative candidate biomarkers of atherosclerosis burden and instability. 

 Histological section of an atherosclerotic carotid plaque, stained for the macrophage marker CD68 

Image: Histological section of an atherosclerotic carotid plaque, stained for the macrophage marker CD68

Collaborations

Sources of Funding

  • Co-Investigator, National Institute for Health Research Health Technology Assessment (NIHR HTA) Project Grant 14/140/61
  • Co-Investigator, National Institute for Health Research Health Technology Assessment / Medical Research Council Efficacy and Mechanism Evaluation (NIHR / MRC EME) Project Grant 15/180/68
  • Royal College of Surgeons of England
  • Circulation Foundation
  • Stroke Association
  • Rosetrees Trust
  • Graham-Dixon Charitable Trust
  • Peel Medical Research Trust

Publications

Journals

Humm G, Harries RL, Derbyshire LF, et al., Teaching ‘Foundation Skills in Surgery’: Evaluating the Association of Surgeons in Training Course, Bulletin of the Royal College of Surgeons of England, ISSN:1473-6357

Milinis K, Shalhoub J, Coupland A, et al., The effectiveness of graduated compression stockings for prevention of venous thromboembolism in orthopedic and abdominal surgery patients requiring extended pharmacological thromboprophylaxis, Journal of Vascular Surgery, ISSN:0741-5214

Nepogodiev D, Chapman SJ, Kolias AG, et al., The impact of trainee research collaboratives in the UK, Lancet Gastroenterology and Hepatology, ISSN:2468-1253

Nepogodiev D, National Surgical Research Collaborative, Shalhoub J, UK surgical trainees will continue to support European research collaboration, The Lancet, ISSN:0140-6736

Sung Y, Spagou K, Kafeza M, et al., Deep vein thrombosis exhibits characteristic serum and vein wall metabolic phenotypes in the inferior vena cava ligation mouse model, European Journal of Vascular and Endovascular Surgery, ISSN:1078-5884

More Publications