Michael Levin is currently Professor of Paediatrics & International Child Health at Imperial College. He trained in medicine in South Africa and in paediatrics in the UK before specialising in infectious diseases. He was Consultant in Infectious Diseases at Great Ormond Street hospital before being appointed as Professor of Paediatrics at Imperial College London in 1990. His research has focused on life threatening infections of childhood including meningococcal disease , childhood tuberculosis. Malaria, and Kawasaki disease, and severe respiratory infections.
He currently leads the EU funded PERFORM study investigating the application of RNA transcriptomics to improve diagnosis of childhood infection. He recently led an ESPID funded consortium studying the genetic basis of meningococcal disease, and is a co-investigator on the FEAST trial, with Professor Maitland, an MRC funded Phase III trial of fluids as supportive treatment for critical illness in African children. He has also led an EU Aid for poverty-related diseases project researching novel diagnostic methods for tuberculosis in Africa working with colleagues in Malawi and South Africa.
Professor Levin's research group continues to study the pathophysiology and genetics of life threatening childhood infections, focusing on meningococcal disease, Kawasaki disease, and mycobacterial infection. The group are applying gene expression profiling and proteomic methods to understand pathophysiology of severe childhood ilnees, and are undertaking genome wide SNP studies linked to expression studies of meningococcal disease, Kawasaki disease and tuberculosis.
Pofessor Levin received an MBE for his services to infectious diseases, critical care and research in paediatrics in the Queen's New Year's honour list in 2017.
et al., 2018, Life-threatening infections in children in Europe (the EUCLIDS Project): a prospective cohort study, Lancet Child and Adolescent Health, Vol:2, ISSN:2352-4642, Pages:404-414
et al., 2018, Mortality and morbidity in community-acquired sepsis in European pediatric intensive care units: a prospective cohort study from the European Childhood Life-threatening Infectious Disease Study (EUCLIDS), Critical Care, Vol:22, ISSN:1364-8535
et al., 2018, Mycobacterium tuberculosis Exploits a Molecular Off Switch of the Immune System for Intracellular Survival, Scientific Reports, Vol:8, ISSN:2045-2322
et al., 2017, Diagnosis of bacterial infection using a 2-transcript host RNA signature in febrile infants 60 days or younger, JAMA - Journal of the American Medical Association, Vol:317, ISSN:0098-7484, Pages:1577-1578
et al., 2016, Diagnostic Test Accuracy of a 2-Transcript Host RNA Signature for Discriminating Bacterial vs Viral Infection in Febrile Children, Journal of the American Medical Association, Vol:316, ISSN:0002-9955, Pages:835-845
Kaforou M, Wright VJ, Levin M, 2014, Host RNA signatures for diagnostics: An example from paediatric tuberculosis in Africa, Journal of Infection, Vol:69, ISSN:0163-4453, Pages:S28-S31
et al., 2014, Diagnosis of Childhood Tuberculosis and Host RNA Expression in Africa, New England Journal of Medicine, Vol:370, ISSN:1533-4406, Pages:1712-1723
et al., 2011, Pathway-driven gene stability selection of two rheumatoid arthritis GWAS identifies and validates new susceptibility genes in receptor mediated signalling pathways, Human Molecular Genetics, Vol:20, Pages:3494-3506