Publications
754 results found
Psarras S, Papadopoulos NG, Johnston SL, 2004, Pathogenesis of respiratory syncytial virus bronchiolitis-related wheezing., Paediatr Respir Rev, Vol: 5 Suppl A, Pages: S179-S184, ISSN: 1526-0542
Respiratory syncytial virus (RSV) is a common cause of virus infection of the human respiratory tract during the first two years of life, with virtually all children experiencing at least one infection within this period. Although this usually leads to mild respiratory illness, some infants develop more severe disease (bronchiolitis, pneumonia, etc.) affecting the lower airways and frequently requiring hospitalisation. There is evidence that bronchiolitis hospitalisations have increased during the last two decades and many of the hospitalised children develop wheezing later in life. The immune response to the virus is probably a major factor in the development or the expression of the pathological phenotype. In particular, a bias towards type-2 cytokine responses seems to be associated with more severe disease, whereas a type-1 response leads to more effective viral clearance and milder illness. Although the virus by itself triggers a type-1 response, a preexisting type-1 deficiency may contribute to the severity of the disease. In that sense, RSV bronchiolitis may serve as a marker, reflecting predisposition of the individual for virus induced wheezing early in life and/or asthma later in life.
Papadopoulos NG, Johnston SL, 2004, Rhinoviruses, Principles and Practice of Clinical Virology Fifth Edition, Editors: Zuckerman, Banatvala, Griffiths, Pattison, Schoub, UK, Publisher: John Wiley & Son
Mallia P, Kebadze T, Johnston SL, 2003, An experimental model of respiratory virus-induced COPD exacerbation - A pilot study, Winter Meeting of the British Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: 34-34, ISSN: 0040-6376
Johnston SL, 2003, Experimental models of rhinovirus-induced exacerbations of asthma - Where to now?, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 168, Pages: 1145-1146, ISSN: 1073-449X
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- Citations: 11
Tuthill TJ, Papadopoulos NG, Jourdan P, et al., 2003, Mouse respiratory epithelial cells support efficient replication of human rhinovirus, JOURNAL OF GENERAL VIROLOGY, Vol: 84, Pages: 2829-2836, ISSN: 0022-1317
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- Citations: 43
Legg JP, Hussain IR, Warner JA, et al., 2003, Type 1 and type 2 cytokine imbalance in acute respiratory syncytial virus bronchiolitis, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 168, Pages: 633-639, ISSN: 1073-449X
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- Citations: 287
Wark PAB, Bucchieri F, Puddicombe SM, et al., 2003, Cytotoxic effects of infection with rhinovirus on asthmatic primary bronchial epithelial cells, 1st Lung Science Meeting of the European-Respiratory-Society, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, Pages: 46S-46S, ISSN: 0903-1936
Abraham B, Antó JM, Barreiro E, et al., 2003, The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma, EUROPEAN RESPIRATORY JOURNAL, Vol: 22, Pages: 470-477, ISSN: 0903-1936
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- Citations: 609
Ichinohe S, Hussain IR, Johnston SL, 2003, Cytokine production of RSV/PHA-stimulated tonsillar mononuclear cells: influences of age and atopy, EUROPEAN RESPIRATORY JOURNAL, Vol: 22, Pages: 317-322, ISSN: 0903-1936
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- Citations: 9
Johnston SL, Unsworth J, Gompels MM, 2003, Cause of reactions should be identified - Authors' reply, BRITISH MEDICAL JOURNAL, Vol: 327, Pages: 227-227, ISSN: 0959-535X
Chauhan AJ, Inskip HM, Linaker CH, et al., 2003, Personal exposure to nitrogen dioxide (NO<sub>2</sub>) and the severity of virus-induced asthma in children, LANCET, Vol: 361, Pages: 1939-1944, ISSN: 0140-6736
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- Citations: 222
Simpson JL, Moric I, Wark PAB, et al., 2003, Use of induced sputum for the diagnosis of influenza and infections in asthma: a comparison of diagnostic techniques, JOURNAL OF CLINICAL VIROLOGY, Vol: 26, Pages: 339-346, ISSN: 1386-6532
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- Citations: 36
Johnston SL, Unsworth J, Gompels MM, 2003, Lesson of the week - Adrenaline given outside the context of life threatening allergic reactions, BRITISH MEDICAL JOURNAL, Vol: 326, Pages: 589-590, ISSN: 0959-535X
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- Citations: 56
Myatt TA, Johnston SL, Rudnick S, et al., 2003, Airborne rhinovirus detection and effect of ultraviolet irradiation on detection by a semi-nested RT-PCR assay, BMC Public Health, Vol: 3, ISSN: 1471-2458
BackgroundRhinovirus, the most common cause of upper respiratory tract infections, has been implicated in asthma exacerbations and possibly asthma deaths. Although the method of transmission of rhinoviruses is disputed, several studies have demonstrated that aerosol transmission is a likely method of transmission among adults. As a first step in studies of possible airborne rhinovirus transmission, we developed methods to detect aerosolized rhinovirus by extending existing technology for detecting infectious agents in nasal specimens.MethodsWe aerosolized rhinovirus in a small aerosol chamber. Experiments were conducted with decreasing concentrations of rhinovirus. To determine the effect of UV irradiation on detection of rhinoviral aerosols, we also conducted experiments in which we exposed aerosols to a UV dose of 684 mJ/m2. Aerosols were collected on Teflon filters and rhinovirus recovered in Qiagen AVL buffer using the Qiagen QIAamp Viral RNA Kit (Qiagen Corp., Valencia, California) followed by semi-nested RT-PCR and detection by gel electrophoresis.ResultsWe obtained positive results from filter samples that had collected at least 1.3 TCID50 of aerosolized rhinovirus. Ultraviolet irradiation of airborne virus at doses much greater than those used in upper-room UV germicidal irradiation applications did not inhibit subsequent detection with the RT-PCR assay.ConclusionThe air sampling and extraction methodology developed in this study should be applicable to the detection of rhinovirus and other airborne viruses in the indoor air of offices and schools. This method, however, cannot distinguish UV inactivated virus from infectious viral particles.
Papi A, Caramori G, Bellettato CM, et al., 2003, Molecular mechanisms of respiratory virus-induced inflammation, Respiratory infections in allergy and asthma, Editors: Papadopoulos, Johnston, New York, Publisher: Marcell Dekker, Pages: 199-228
Papadopoulos NG, Johnston SL, 2003, Mallia P, Johnston SL. Respiratory viruses: do they protect from or induce asthma? In: Respiratory infections in allergy and asthma., New York, Publisher: Marcel Dekker, Pages: 101-116
Creer DD, Gelder CM, Johnston SL, 2003, Treatment of the Common Cold: prospects and implications for the treatment of asthma exacerbations, Respiratory infections in allergy and asthma, Editors: Papadopoulos, Johnston, New York, Publisher: Marcell Dekker, Pages: 675-710
Wedzicha JA, Johnston SL, Mitchell DM, 2003, New year: new editors, Thorax, Vol: 1, Pages: 1-2
Schwarze J, Johnston SL, 2003, Virus-induced wheezing, Leukotriene Research & Clinical Review, Vol: 4, Pages: 1-4
Papi A, Message SD, Papadopoulos NG, et al., 2003, Respiratory Viruses and asthma, European Respiratory Monograph, Vol: 23, Pages: 223-238
Johnston SL, 2003, Respiratory infections in allergy and asthma, New York, Publisher: Marcell Dekker
Taylor P, Johnston SL, 2003, Detection of Respiratory Viruses, Respiratory Medicine Third Edition, Editors: Gibson, Geddes, Costabel, Sterk, Corrin, London, Publisher: Elsevier Science Limited, Pages: 385-390
Chauhan AJ, Johnston SL, 2003, Air pollution and infection in respiratory illness, BRITISH MEDICAL BULLETIN, Vol: 68, Pages: 95-112, ISSN: 0007-1420
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- Citations: 159
Hussain I, Johnston SL, 2003, Viral Infections: Effects on nasal and lower airway functions, Upper and Lower Respiratory Disease, Editors: Corren, Togias, Bousquet, New York, Publisher: Marcel Dekker, Inc
Mallia P, Johnston SL, 2003, Treatment of Respiratory Viruses, Horizons in Medicine - Updates in Major Clinical Advances, Editors: Weber, London UK, Publisher: Royal College of Physicians, Pages: 145-152
Seemungal TAR, Wedzicha JA, MacCallum PK, et al., 2002, <i>Chlamydia pneumoniae</i> and COPD exacerbation, THORAX, Vol: 57, Pages: 1087-1088, ISSN: 0040-6376
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- Citations: 26
Gompels LL, bethune C, Johnston SL, et al., 2002, Proposed use of adrenaline (epinephrine) in anaphylaxis and related conditions: a study of senior house officers starting accident and emergency posts., Postgraduate Medical Journal, Vol: 78, Pages: 416-418
Pala P, Message SD, Johnston SL, et al., 2002, Increased aeroallergen-specific interleukin-4-producing T cells in asthmatic adults, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 32, Pages: 1739-1744, ISSN: 0954-7894
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- Citations: 14
Mallia P, Johnston SL, 2002, Respiratory viruses: do they protect from or induce asthma?, ALLERGY, Vol: 57, Pages: 1118-1129, ISSN: 0105-4538
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- Citations: 23
Papi A, Papadopoulos NG, Stanciu LA, et al., 2002, Reducing agents inhibit rhinovirus-induced up-regulation of the rhinovirus receptor intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells, FASEB JOURNAL, Vol: 16, Pages: 1934-+, ISSN: 0892-6638
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- Citations: 40
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