Publications
1335 results found
Al Saikhan L, Park C, Hardy R, et al., 2019, Prognostic implications of left ventricular strain by speckle-tracking echocardiography in the general population: a meta-analysis, VASCULAR HEALTH AND RISK MANAGEMENT, Vol: 15, Pages: 229-251, ISSN: 1176-6344
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- Citations: 24
Chattopadhyay K, Chandrasekaran AM, Praveen PA, et al., 2019, Development of a Yoga-Based Cardiac Rehabilitation (Yoga-CaRe) Programme for Secondary Prevention of Myocardial Infarction, EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, Vol: 2019, ISSN: 1741-427X
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- Citations: 7
Prabhakaran D, Chandrasekaran AM, Singh K, et al., 2018, Effectiveness of a Yoga-Based Cardiac Rehabilitation (yoga-care) Program: A Multi-Centre Randomised Controlled Trial of 4,014 Patients With Acute Myocardial Infarction From India, Scientific Sessions of the American-Heart-Association (AHA) / Resuscitation Science Symposium, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: E756-E756, ISSN: 0009-7322
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- Citations: 1
Hughes A, Rood DH, Whittaker AC, et al., 2018, Geomorphic evidence for the geometry and slip rate of a young, low-angle thrust fault: Implications for hazard assessment and fault interaction in complex tectonic environments, Earth and Planetary Science Letters, Vol: 504, Pages: 198-210, ISSN: 0012-821X
We present surface evidence and displacement rates for a young, active, low-angle (∼20°) reverse thrust fault in close proximity to major population centers in southern California (USA), the Southern San Cayetano fault (SSCF). Active faulting along the northern flank of the Santa Clara River Valley displaces young landforms, such as late Quaternary river terraces and alluvial fans. Geomorphic strain markers are examined using field mapping, high-resolution lidar topographic data, 10Be surface exposure dating, and subsurface well data to provide evidence for a young, active SSCF along the northern flank of the Santa Clara River Valley. Displacement rates for the SSCF are calculated over 103–104 yr timescales with maximum slip rates for the central SSCF of 1.9[Formula presented] mm yr−1 between ∼19–7 ka and minimum slip rates of 1.3[Formula presented] mm yr−1 since ∼7 ka. Uplift rates for the central SSCF have not varied significantly over the last ∼58 ka, with a maximum value of 1.7[Formula presented] mm yr−1 for the interval ∼58–19 ka, and a minimum value of 1.2±0.3 mm yr−1 since ∼7 ka. The SSCF is interpreted as a young, active structure with onset of activity at some time after ∼58 ka. The geometry for the SSCF presented here, with a ∼20° north dip in the subsurface, is the first interpretation of the SSCF based on geological field data. Our new interpretation is significantly different from the previously proposed model-derived geometry, which dips more steeply at 45–60° and intersects the surface in the middle of the Santa Clara River Valley. We suggest that the SSCF may rupture in tandem with the main San Cayetano fault. Additionally, the SSCF could potentially act as a rupture pathway between the Ventura and San Cayetano faults in large-magnitude, multi-fault earthquakes in southern California. However, given structural complexities, including significant changes
Negoita M, Hughes AD, Parker KH, et al., 2018, A method for determining local pulse wave velocity in human ascending aorta from sequential ultrasound measurements of diameter and velocity, PHYSIOLOGICAL MEASUREMENT, Vol: 39, ISSN: 0967-3334
Wade KH, Chiesa ST, Hughes AD, et al., 2018, Assessing the Causal Role of Body Mass Index on Cardiovascular Health in Young Adults Mendelian Randomization and Recall-by-Genotype Analyses, CIRCULATION, Vol: 138, Pages: 2187-2201, ISSN: 0009-7322
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- Citations: 40
Chiesa ST, Masi S, Shipley M, et al., 2018, Carotid Artery Wave Intensity Measured in Mid- to Late-Life Predicts Future Cognitive Decline: The Whitehall II Study, Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0009-7322
Joshi R, Wannamethee G, Rhodes D, et al., 2018, Triglyceride-Containing Lipoprotein Sub-Fractions and Coronary Heart Disease and Stroke Risk, Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0009-7322
Sudre CH, Smith L, Atkinson D, et al., 2018, Cardiovascular Risk Factors and White Matter Hyperintensities: Difference in Susceptibility in South Asians Compared With Europeans, JOURNAL OF THE AMERICAN HEART ASSOCIATION, Vol: 7, ISSN: 2047-9980
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- Citations: 21
O'Keeffe LM, Simpkin AJ, Tilling K, et al., 2018, Sex-specific trajectories of measures of cardiovascular health during childhood and adolescence: A prospective cohort study, ATHEROSCLEROSIS, Vol: 278, Pages: 190-196, ISSN: 0021-9150
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- Citations: 28
Park C, Fraser A, Howe LD, et al., 2018, Elevated Blood Pressure in Adolescence Is Attributable to a Combination of Elevated Cardiac Output and Total Peripheral Resistance: Evidence Against a Hyperkinetic State, HYPERTENSION, Vol: 72, Pages: 1103-1108, ISSN: 0194-911X
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- Citations: 7
Campbell MD, Laitinen TT, Hughes A, et al., 2018, Impact of Ideal Cardiovascular Health in Childhood on the Retinal Microvasculature in Midadulthood: Cardiovascular Risk in Young Finns Study, JOURNAL OF THE AMERICAN HEART ASSOCIATION, Vol: 7, ISSN: 2047-9980
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- Citations: 14
Park C, Richards M, Hardy R, et al., 2018, The heart-brain connection in the 1946 British Birth Cohort, Publisher: NATURE PUBLISHING GROUP, Pages: 708-709, ISSN: 0950-9240
Taylor H, Park C, Fraser A, et al., 2018, Mediation by blood pressure and other risk factors of relationships between body composition and cardiac structure in adolescents, Publisher: NATURE PUBLISHING GROUP, Pages: 694-695, ISSN: 0950-9240
Huang Z, Fonseca R, Sharman JE, et al., 2018, ASSOCIATIONS BETWEEN EXERCISE BLOOD PRESSURE AND LEFT-VENTRICULAR MASS ARE INFLUENCED BY CARDIORESPIRATORY FITNESS IN ADOLESCENCE, 27th Scientific Meeting of the International-Society-of-Hypertension, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: E156-E156, ISSN: 0263-6352
Petrie JR, Chaturvedi N, Ford I, et al., 2018, The REMOVAL trial: metformin reduces progression of mean carotid intima-media thickness (cIMT) in never smokers with type 1 diabetes, 54th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Publisher: SPRINGER, Pages: S555-S555, ISSN: 0012-186X
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- Citations: 1
Picone D, Schultz M, Otahal P, et al., 2018, CUFF BLOOD PRESSURE IS PROGRESSIVELY MORE BIASED WITH INCREASING AGE: INDIVIDUAL PARTICIPANT LEVEL ANALYSIS FROM THE INSPECT CONSORTIUM, 27th Scientific Meeting of the International-Society-of-Hypertension, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: E246-E246, ISSN: 0263-6352
Wade KH, Chiesa ST, Hughes AD, et al., 2018, Assessing the causal role of body mass index on cardiovascular health in young adults: a Mendelian randomization and recall-by-genotype analysis, 50th European-Society-of-Human-Genetics (ESHG) Conference, Publisher: NATURE PUBLISHING GROUP, Pages: 63-64, ISSN: 1018-4813
, 2018, Abstracts from the 2018 Annual Scientific Meeting of the British and Irish Hypertension Society (BIHS)., J Hum Hypertens, Vol: 32, Pages: 693-721
Michail M, Dehbi H-M, Davies J, et al., 2018, Reducing the need for invasive pressure wire assessment in patients using a novel angiographic scoring tool, 30th Annual Symposium on Transcatheter Cardiovascular Therapeutics (TCT), Publisher: ELSEVIER SCIENCE INC, Pages: B65-B66, ISSN: 0735-1097
Leeuwis AE, Smith LA, Melbourne A, et al., 2018, Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort: The SABRE Study, FRONTIERS IN AGING NEUROSCIENCE, Vol: 10, ISSN: 1663-4365
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- Citations: 45
Magnus MC, Hughes AD, Williams C, et al., 2018, Hypertensive Disorders During Pregnancy and Offspring Retinal Microvasculature During Adolescence, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 72, Pages: 1318-1320, ISSN: 0735-1097
Hughes AD, Chaturvedi N, 2018, Estimation of maximal oxygen consumption and heart rate recovery using the Tecumseh sub-maximal step test and their relationship to cardiovascular risk factors (vol 18, pg 29, 2017), ARTERY RESEARCH, Vol: 23, Pages: 44-44, ISSN: 1872-9312
Al Saikhan L, Park C, Hardy R, et al., 2018, Prognostic implications of left ventricular strain by speckle-tracking echocardiography in population-based studies: a systematic review protocol of the published literature, BMJ OPEN, Vol: 8, ISSN: 2044-6055
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- Citations: 6
Kyriacou A, Rajkumar CA, Pabari P, et al., 2018, Distinct impacts of heart rate and right atrial-pacing on left atrial mechanical activation and optimal AV delay in CRT, Pacing and Clinical Electrophysiology, Vol: 41, Pages: 959-966, ISSN: 0147-8389
AbstractBackgroundControversy exists regarding how atrial activation mode and heart rate affect optimal AV delay in cardiac resynchronisation therapy. We studied these questions using high‐reproducibility haemodynamic and echocardiographic measurements.Methods20 patients were hemodynamically optimized using non‐invasive beat‐to‐beat blood pressure at rest (62±11 bpm), during exercise (80±6 bpm) and at 3 atrially‐paced rates: 5, 25 and 45 bpm above rest, denoted Apaced,r+5, Apaced,r+25 and Apaced,r+45 respectively. Left atrial myocardial motion and transmitral flow were timed echocardiographically.ResultsDuring atrial‐sensing, raising heart rate shortened optimal AV delay by 25±6 ms (p < 0.001). During atrial pacing, raising heart rate from Apaced,r+5 to Apaced,r+25 shortened it by 16±6 ms; Apaced,r+45 shortened it 17±6 ms further (p < 0.001).In comparison to atrial‐sensed activation, atrial pacing lengthened optimal AV delay by 76±6 ms (p < 0.0001) at rest, and at ∼20 bpm faster, by 85±7 ms (p < 0.0001), 9±4 ms more (p = 0.017). Mechanically, atrial pacing delayed left atrial contraction by 63±5 ms at rest and by 73±5 ms (i.e. by 10±5 ms more, p < 0.05) at ∼20 bpm faster.Raising atrial rate by exercise advanced left atrial contraction by 7±2 ms (p = 0.001). Raising it by atrial pacing did not (p = 0.2).ConclusionsHemodynamic optimal AV delay shortens with elevation of heart rate. It lengthens on switching from atrial‐sensed to atrial‐paced at the same rate, and echocardiography shows this sensed‐paced difference in optima results from a sensed‐paced difference in atrial electromechanical delay.The reason for the widening of the sensed‐paced difference in AV optimum may be physiological stimuli (e.g. adrenergic drive) advancing left atrial contraction during exercise but not with fast atrial pacing.
Bhuva A, Treibel TA, De Marvao A, et al., 2018, Septal hypertrophy in aortic stenosis and its regression after valve replacement is more plastic in males than females: insights from 3D machine learning approach, European-Society-of-Cardiology Congress, Publisher: European Society of Cardiology, Pages: 1132-1132, ISSN: 0195-668X
Background: Evaluation of left ventricular non-compaction (LVNC) is an increasingly common indication for cardiac magnetic resonance imaging (MRI). Fractal dimension (FD) is a unitless measure of geometrical complexity which can be used to quantify LV trabeculation. FD is increased in LVNC, but there have been few studies on FD in normal subjects. The aim of the study was to establish reference ranges for FD in a healthy population, and identify covariates which are associated with FD.Methods: MRI was performed in 1,913 volunteers without hypertension, diabetes, or heart disease (1055 female, 858 male; median age 40, range 19-82). FD was derived from LV short-axis images, using a custom MATLAB box-counting algorithm. The maximal FD in the apical half of the LV was used for all analyses, as previously described.Results: Normal ranges (2.5-97.5th percentile) for female and male subjects were 1.154 - 1.367 and 1.179 - 1.392, respectively. FD was significantly correlated with age, gender, ethnicity, body surface area (BSA), activity score, and systolic blood pressure. In multivariable analysis, FD was independently correlated with increased age (β 0.11, p<0.001), male gender (β 0.09, p<0.001), African/Afro-Caribbean ethnicity (β 0.18, p<0.001), increased BSA (β 0.27, p<0.001), and increased activity score (β 0.07, p=0.002). Since ethnicity was found to significantly affect FD, normal ranges were calculated for each subgroup (see table).Conclusions: This is the largest study on FD in healthy subjects, and the first to present gender- and race-specific normal ranges. The association between FD and age suggests that LV trabeculation is a dynamic phenotype which may change with age.
Van Zalen JJ, D'Silva A, Badiani S, et al., 2018, Linking myocardial mechanical function to exercise performance: a cardiopulmonary stress echo study in first time London marathon participants, European-Society-of-Cardiology Congress, Publisher: OXFORD UNIV PRESS, Pages: 155-155, ISSN: 0195-668X
D'Silva A, Bhuva AN, Jones S, et al., 2018, Exercise-induced left ventricular trabeculation: real entity or fake news?, European-Society-of-Cardiology Congress, Publisher: OXFORD UNIV PRESS, Pages: 89-89, ISSN: 0195-668X
Cook S, Malyutina S, Kudryavtsev AV, et al., 2018, Know Your Heart: Rationale, design and conduct of a cross-sectional study of cardiovascular structure, function and risk factors in 4500 men and women aged 35-69 years from two Russian cities, 2015-18 [version 2; referees: 3 approved], Wellcome Open Research, Vol: 3, Pages: 67-67, ISSN: 2398-502X
Russia has one of the highest rates of cardiovascular disease in the world. The International Project on Cardiovascular Disease in Russia (IPCDR) was set up to understand the reasons for this. A substantial component of this study was the Know Your Heart Study devoted to characterising the nature and causes of cardiovascular disease in Russia by conducting large cross-sectional surveys in two Russian cities Novosibirsk and Arkhangelsk. The study population was 4542 men and women aged 35-69 years recruited from the general population. Fieldwork took place between 2015-18. There were two study components: 1) a baseline interview to collect information on socio-demographic characteristics and cardiovascular risk factors, usually conducted at home, and 2) a comprehensive health check at a primary care clinic which included detailed examination of the cardiovascular system. In this paper we describe in detail the rationale for, design and conduct of these studies.
Treibel TA, Kozor R, Fontana M, et al., 2018, Sex Dimorphism in the Myocardial Response to Aortic Stenosis, JACC-CARDIOVASCULAR IMAGING, Vol: 11, Pages: 962-973, ISSN: 1936-878X
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- Citations: 71
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