Imperial College London
Alternate

ProfessorAlunHughes

Faculty of Medicine, National Heart & Lung Institute

Visiting Professor
 
 
 
//

Contact

 

a.hughes Website

 
 
//

Assistant

 

Mrs Kim Cyrus +44 (0)20 7594 6047

 
//

Location

 

59/61 North Wharf RoadSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Farmaki:2019:10.1101/2019.12.13.19014704,
author = {Farmaki, A-E and Garfield, V and Eastwood, SV and Farmer, RE and Mathur, R and Patalay, P and Sattar, N and Hughes, A and Bhaskaran, K and Smeeth, L and Chaturvedi, N},
doi = {10.1101/2019.12.13.19014704},
title = {Type 2 diabetes risks and determinants in 2<sup>nd</sup> generation migrants and mixed ethnicity people of South Asian and African Caribbean descent in the UK},
url = {http://dx.doi.org/10.1101/2019.12.13.19014704},
year = {2019}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Type 2 diabetes mellitus (T2DM) risk is markedly higher in UK South Asians (SA) and African Caribbeans (AC) compared to Europeans. Explanations for this excess are unclear. We therefore compared risks and determinants of T2DM in first- and second-generation (born in the UK) migrants, and in those of mixed ethnicity populations.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Data from the UK Biobank, a large population-based cohort of volunteers aged 40-69, were used. T2DM was assigned using self-report and glycated haemoglobin. Ethnicity was self-assigned. Using logistic regression and mediation analysis, we compared T2DM between first- and second-generation migrants, and between mixed European/South Asians (MixESA), or mixed European/African Caribbeans (MixEAC) with both Europeans and SA or AC respectively.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>T2DM prevalence was three to five times higher in SA and AC compared with Europeans [OR (95%CI): 4·80(3·60,6·40) and 3·30(2·70,4·10) respectively]. T2DM was 20-30% lower in second versus first generation SA and AC migrants [0·78(0·60,1·01) and 0·71(0·57,0·87) respectively]. T2DM in mixed populations was lower than comparator ethnic minority groups [MixESA versus SA 0·29(0·21,0·39), MixEAC versus AC 0·48(0·37,0·62)] and higher than Europeans, in MixESA 1·55(1·11, 2·17), and in MixEAC 2·06 (1·53, 2·78). Improved adiposity patterns in second generation migrants made an important contribution to risk reduction. Greater socioeconomic deprivation accounted for 17% and 42% of the excess risk of T2DM in MixESA and MixEAC comp
AU  - Farmaki,A-E
AU  - Garfield,V
AU  - Eastwood,SV
AU  - Farmer,RE
AU  - Mathur,R
AU  - Patalay,P
AU  - Sattar,N
AU  - Hughes,A
AU  - Bhaskaran,K
AU  - Smeeth,L
AU  - Chaturvedi,N
DO  - 10.1101/2019.12.13.19014704
PY  - 2019///
TI  - Type 2 diabetes risks and determinants in 2<sup>nd</sup> generation migrants and mixed ethnicity people of South Asian and African Caribbean descent in the UK
UR  - http://dx.doi.org/10.1101/2019.12.13.19014704
ER  -
Download