Imperial College London
Alternate

ProfessorEricAlton

Faculty of Medicine, National Heart & Lung Institute

Chair in Gene Therapy
 
 
 
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Contact

 

+44 (0)20 7594 7929e.alton

 
 
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Assistant

 

Miss Samia Soussi +44 (0)20 7594 7980

 
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Location

 

Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

600 results found

Davies JC, Cunningham S, Alton EWFW, Innes JAet al., 2008, Lung clearance index in CF: a sensitive marker of lung disease severity, THORAX, Vol: 63, Pages: 96-97, ISSN: 0040-6376

Journal article

Horsley AR, Gustafsson PM, Macleod KA, Saunders C, Greening AP, Porteous DJ, Davies JC, Cunningham S, Alton EWFW, Innes JAet al., 2008, Lung clearance index is a sensitive, repeatable and practical measure of airways disease in adults with cystic fibrosis, THORAX, Vol: 63, Pages: 135-140, ISSN: 0040-6376

Journal article

Rakonczay Z, Hegyi P, Hasegawa M, Inoue M, You J, Iida A, Ignath I, Alton EWFW, Griesenbach U, Ovari G, Vag J, Da Paula AC, Crawford RM, Varga G, Amaral MD, Mehta A, Lonovics J, Argent BE, Gray MAet al., 2008, CFTR gene transfer to human cystic fibrosis pancreatic duct cells using a sendai virus vector, JOURNAL OF CELLULAR PHYSIOLOGY, Vol: 214, Pages: 442-455, ISSN: 0021-9541

Journal article

Green A, Alton E, 2008, Cardiac repair clinical trials, Advances in Tissue Engineering, Pages: 695-731, ISBN: 9781848161825

Cardiovascular disease is a major problem worldwide, and remains the leading cause of death within Europe. Clinical trials of stem cells have been conducted in the setting of acute myocardial infarction and chronic heart disease. At the time of writing there have been a number of different cell types, preparation and doses delivered by a number of different delivery routes to a variety of patients in small, mostly uncontrolled trials, generally with positive outcomes. Larger placebo-controlled trials are ongoing and we eagerly await their results. The challenges currently facing the field are to define the optimal target patient population, cell source, preparation, dose, delivery and retention of cells within the myocardium and the appropriate assays to detect meaningful clinical changes. Clearly not all of these questions can be answered in the clinical trial setting and it is imperative that basic science and translational research are conducted simultaneously to help guide clinical research. At present there appears to be no clear steer in answering these questions but we attempt to discuss the evidence to date and the future of stem cells in the management of cardiovascular disease.

Book chapter

Regamey N, Hilliard TN, Saglani S, Zhu J, Balfour-Lynn IM, Rosenthal M, Jeftery PK, Alton EWFV, Bush A, Davies JCet al., 2008, Endobronchial biopsy in childhood, CHEST, Vol: 133, Pages: 312-312, ISSN: 0012-3692

Journal article

Griesenbach U, Munkonge FM, Sumner-Jones S, Holder E, Smith SN, Boyd AC, Gill DR, Hyde SC, Porteous D, Alton EWFW, UK Cystic Fibrosis Gene Therapy Consortiumet al., 2008, Assessment of CFTR function after gene transfer in vitro and in vivo., Methods Mol Biol, Vol: 433, Pages: 229-242, ISSN: 1064-3745

Cystic fibrosis (CF) a monogenic lethal disease and, therefore, ideally suited for the development of gene therapy. The first clinical trials were carried out shortly after cloning the CF gene in 1989. Since then, 25 trials have been carried out. Proof of principle for low-level airway gene transfer was established in most, but not all, trials. It is currently unclear whether current gene transfer efficiency will lead to improvements in clinically relevant endpoints such as inflammation or infection. In addition to addressing this important question, we and others are further improving airway gene transfer, by modifying existing and developing new gene transfer agents. Here, we describe pre-clinical methods related to assessing correction of the CF chloride transport defect.

Journal article

Davies JC, Alton EWFW, Bush A, 2007, Cystic fibrosis, BMJ-BRITISH MEDICAL JOURNAL, Vol: 335, Pages: 1255-1259, ISSN: 1756-1833

Journal article

Aziz ZA, Wells A, Meister M, Tyler P, Davies J, Alton E, Innes A, Gray R, Horsley A, Hansell Det al., 2007, Computed tomography in infective exacerbations in cystic fibrosis: Serial change and observer agreement, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A30-A31, ISSN: 0040-6376

Conference paper

Alexander BL, Ali RR, Alton EWFW, Bainbridge JW, Braun S, Cheng SH, Flotte TR, Gaspar HB, Grez M, Griesenbach U, Kaplitt MG, Ott MG, Seger R, Simons M, Thrasher AJ, Thrasher AZ, Herttuala SYet al., 2007, Progress and prospects: gene therapy clinical trials (part 1) (vol 14, pg 1439, 2007), GENE THERAPY, Vol: 14, Pages: 1754-1754, ISSN: 0969-7128

Journal article

Xenariou S, Griesenbach U, Liang HD, Zhu J, Farley R, Somerton L, Singh C, Jeffery PK, Blomley M, Alton Eet al., 2007, Assessing ultrasound as a method to enhance non-viral gene transfer to the lung, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A105-A105, ISSN: 0040-6376

Conference paper

Griesenbach U, Jeswiet SB, Larsen MDB, Bakar Y, Voase NWG, Gammie FM, Mullard KE, Geddes DM, Davies JC, Alton EWFW, Marriott C, Gray R, Horsley A, Imrie M, Dewar M, Greening AP, Innes Aet al., 2007, UK cf gene therapy consortium tracking study: Change in sputum properties in response to IV antibiotics, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A30-A30, ISSN: 0040-6376

Conference paper

Hilliard TN, Regamey N, Shute JK, Nicholson AG, Alton EWFW, Bush A, Davies JCet al., 2007, Airway remodelling in children with cystic fibrosis, THORAX, Vol: 62, Pages: 1074-1080, ISSN: 0040-6376

Journal article

Larsen MDB, Griesenbach U, Goussard S, Geddes DM, Grillot-Courvalin C, Alton EWFWet al., 2007, Bactofection into airway epithelial cells in vitro and in vivo using a genetically modified Escherichia coli, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A105-A105, ISSN: 0040-6376

Conference paper

Horsley AR, Aziz Z, Macleod KA, Saunders CJ, Meister M, Tyler P, Dewar M, Gray R, Voase N, Cunningham S, Greening AP, Davies JC, Alton EWFW, Hansell D, Innes JAet al., 2007, Functional and structural changes in the cystic fibrosis lung following antibiotic treatment for exacerbation, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A31-A31, ISSN: 0040-6376

Conference paper

Ban H, Inoue M, Griesenbach U, Munkonge F, Chan M, Iida A, Alton E, Hasegawa Met al., 2007, Expression and maturation of Sendai virus vector-derived CFTR protein: functional and biochemical evidence using a GFP-CFTR fusion protein, GENE THERAPY, Vol: 14, Pages: 1688-1694, ISSN: 0969-7128

Journal article

Davies JC, Voase N, Dewar M, Mullard K, Gammie F, Saunders C, Horsley A, Gray R, Macleod K, Somerton L, Higgins T, Donovan J, Cornish N, Ashby D, Geddes D, Greening A, Cunningham S, Innes A, Alton Eet al., 2007, Uk CF gene therapy consortium tracking study: Response of clinically available assays to intravenous antibiotics, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A30-A30, ISSN: 0040-6376

Conference paper

Alton E, Ferrari S, Griesenbach U, 2007, Progress and prospects: Gene therapy clinical trials (part 2), GENE THERAPY, Vol: 14, Pages: 1555-1563, ISSN: 0969-7128

Journal article

Alton E, 2007, Progress and prospects: Gene therapy clinical trials (part 1), GENE THERAPY, Vol: 14, Pages: 1439-1447, ISSN: 0969-7128

Journal article

Ferrari S, Griesenbach U, Iida A, Farley R, Wright AM, Zhu J, Munkonge FM, Smith SN, You J, Ban H, Inoue M, Chan M, Singh C, Verdon B, Argent BE, Wainwright B, Jeffery PK, Geddes DM, Porteous DJ, Hyde SC, Gray MA, Hasegawa M, Alton EWFWet al., 2007, Sendai virus-mediated CFTR gene transfer to the airway epithelium, GENE THERAPY, Vol: 14, Pages: 1371-1379, ISSN: 0969-7128

Journal article

Regamey N, Hilliard TN, Saglani S, Zhu J, Scallan M, Balfour-Lynn IM, Rosenthal M, Jeffery PK, Alton EWFW, Bush A, Davies JCet al., 2007, Quality, size, and composition of pediatric endobronchial biopsies in cystic fibrosis, CHEST, Vol: 131, Pages: 1710-1717, ISSN: 0012-3692

Journal article

Xenariou S, Griesenbach U, Liang H-D, Zhu J, Farley R, Somerton L, Singh C, Jeffery PK, Ferrari S, Scheule RK, Cheng SH, Geddes DM, Blomley M, Alton EWFWet al., 2007, Use of ultrasound to enhance nonviral lung gene transfer in vivo, GENE THERAPY, Vol: 14, Pages: 768-774, ISSN: 0969-7128

Journal article

Alton EWFW, Davies JC, Geddes DM, 2007, Biomarkers for cystic fibrosis - Are we progressing?, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 175, Pages: 750-751, ISSN: 1073-449X

Journal article

Aziz ZA, Davies JC, Alton EW, Wells AU, Geddes DM, Hansell DMet al., 2007, Computed tomography and cystic fibrosis: promises and problems, THORAX, Vol: 62, Pages: 181-186, ISSN: 0040-6376

Journal article

McLachlan G, Baker A, Tennant P, Gordon C, Vrettou C, Renwick L, Blundell R, Cheng SH, Scheule RK, Davies L, Painter H, Coles RL, Lawton AE, Marriott C, Gill DR, Hyde SC, Griesenbach U, Alton EWFW, Boyd AC, Porteous DJ, Collie DDSet al., 2007, Optimizing aerosol gene delivery and expression in the ovine lung, MOLECULAR THERAPY, Vol: 15, Pages: 348-354, ISSN: 1525-0016

Journal article

Regamey N, Ochs M, Hilliard TN, Muehlfeld C, Cornish N, Fleming L, Saglani S, Alton EW, Bush A, Jeffery P, Davies JCet al., 2007, Airway smooth muscle remodeling in children with cystic fibrosis, PEDIATRIC PULMONOLOGY, Pages: 349-350, ISSN: 8755-6863

Journal article

Alton E, 2007, Measures of CFTR molecular and clinical function, 21st Annual North American Cystic Fibrosis Conference, Publisher: WILEY-LISS, Pages: 178-179, ISSN: 8755-6863

Conference paper

Horsley A, Macleod K, Saunders C, Gray RD, Dewar M, Voase N, Porteous D, Boyd C, Hyde S, Gill D, Geddes D, Greening AP, Cunningham S, Davies JC, Alton E, Innes JAet al., 2007, UKCF gene therapy consortium tracking study: Lung clearance index improves with treatment of an infective exacerbation, PEDIATRIC PULMONOLOGY, Pages: 335-336, ISSN: 8755-6863

Journal article

Gray RD, Horsley A, Macleod K, Imrie M, Dewar M, Voase N, Donovan J, Hyde S, Gill D, Griesenbach U, Davies JC, Alton E, Boyd AC, Porteous D, Cunningham S, Innes JA, Greening APet al., 2007, UKCF gene therapy consortium tracking study: Sputum and serum calprotectin are useful novel measurements in CF exacerbation, PEDIATRIC PULMONOLOGY, Pages: 338-338, ISSN: 8755-6863

Journal article

Reizarney N, Tsartsali L, Hilliard TN, Cornish N, Zhu J, Jeffery PK, Alton EW, Bush A, Davies JCet al., 2007, Airway mucosa inflammation in children with cystic fibrosis, PEDIATRIC PULMONOLOGY, Pages: 262-263, ISSN: 8755-6863

Journal article

Macleod K, Horsley A, Gray R, Imrie M, Leiton J, Dewar M, Voase N, Saunders C, Hyde S, Gill D, Geddes D, Davies JC, Alton E, Porteous D, Boyd C, Cunningham S, Innes JA, Greening Aet al., 2007, UK cystic fibrosis gene therapy consortium tracking study: Exhaled breath condensate pH increases with treatment of an infective exacerbation, PEDIATRIC PULMONOLOGY, Pages: 343-344, ISSN: 8755-6863

Journal article

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