Publications
600 results found
Davies JC, Alton EWFW, 2005, Airway Gene Therapy, NON-VIRAL VECTORS FOR GENE THERAPY, SECOND EDITION: PART 2, Vol: 54, Pages: 291-314, ISSN: 0065-2660
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- Citations: 14
Davies JC, Alton EWFW, 2005, Non-viral vectors for gene therapy, Airway gene therapy., Editors: Huang, Hung, Wagner, Pages: 291-314
Hilliard TN, Shute J, Nicholson AG, et al., 2004, Transforming growth factor β1 and airway remodelling in children with cystic fibrosis, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: 25-26, ISSN: 0040-6376
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- Citations: 3
McLachlan G, Griesenbach U, Owaki T, et al., 2004, Recombinant Sendai virus vector to evaluate vector distribution in a large animal model of lung gene transfer, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: 25-25, ISSN: 0040-6376
Wodehouse T, Collins LA, Farley R, et al., 2004, Cystic fibrosis mice display increased adherence of <i>Pseudomonas aeruginosa</i> to respiratory epithelia of a similar degree to that observed in humans, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: 24-25, ISSN: 0040-6376
Low T, Lympany PA, Davies JC, et al., 2004, Analysis of the effect of inflammatory gene polymorphisms on clinical phenotype in cystic fibrosis, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: 25-25, ISSN: 0040-6376
Griesenbach U, Larsen MDB, Smith SN, et al., 2004, Airway surface liquid height and nasal potential difference measurements in FABP-CF knockout mice: A core facility for screening of non-viral gene transfer agents, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: 27-27, ISSN: 0040-6376
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- Citations: 2
Griesenbach U, Geddes DM, Alton EWFW, 2004, Advances in cystic fibrosis gene therapy, CURRENT OPINION IN PULMONARY MEDICINE, Vol: 10, Pages: 542-546, ISSN: 1070-5287
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- Citations: 26
Ferrari S, Griesenbach U, Shirai-Iida T, et al., 2004, A defective nontransmissible recombinant Sendai virus mediates efficient gene transfer to airway epithelium in vivo, GENE THERAPY, Vol: 11, Pages: 1659-1664, ISSN: 0969-7128
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- Citations: 44
Davies JC, Turner MW, Klein N, 2004, Impaired pulmonary status in cystic fibrosis adults with two mutated <i>MBL-2</i> alleles, EUROPEAN RESPIRATORY JOURNAL, Vol: 24, Pages: 798-804, ISSN: 0903-1936
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- Citations: 52
Griesenbach U, Geddes DM, Alton EWFW, 2004, Gene therapy for cystic fibrosis: an example for lung gene therapy, GENE THERAPY, Vol: 11, Pages: S43-S50, ISSN: 0969-7128
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- Citations: 44
Radke PW, Kivela A, Vick T, et al., 2004, Efficacy of vascular oligonucleotide transfer using polymer-coated stents, 16th Annual Transcatheter Cardiovascular Therapeutics Symposium, Publisher: EXCERPTA MEDICA INC, Pages: 27E-28E, ISSN: 0002-9149
Ferrari S, Griesenbach U, Farley R, et al., 2004, Recombinant sendai virus mediates CFTR gene transfer to airway epithelium both <i>in vitro</i> and <i>in vivo</i>, 1st Annual Conference of the British-Society-for-Gene-Therapy, Publisher: JOHN WILEY & SONS LTD, Pages: S19-S19, ISSN: 1099-498X
Griesenbach U, Darlay R, Marshall N, et al., 2004, Optimisation of adenoviral and plasmid-mediated gene transfer to the murine myocardium, 1st Annual Conference of the British-Society-for-Gene-Therapy, Publisher: JOHN WILEY & SONS LTD, Pages: S22-S22, ISSN: 1099-498X
Griesenbach U, Kitson C, Escudero-Garcia S, et al., 2004, LacZ siRNA and antisense DNA decrease β-galactosidase mRNA but not protein expression in the airways of K18-lacZ transgenic mice, 1st Annual Conference of the British-Society-for-Gene-Therapy, Publisher: JOHN WILEY & SONS LTD, Pages: S21-S22, ISSN: 1099-498X
Munkonge FM, Hillery E, Smith JWS, et al., 2004, Characterisation of cytosolic DNA-binding karyophilic shuttle proteins mediating plasmid DNA import into mammalian cell nuclei, 1st Annual Conference of the British-Society-for-Gene-Therapy, Publisher: JOHN WILEY & SONS LTD, Pages: S8-S8, ISSN: 1099-498X
Munkonge F, Alton EWFW, Andersson C, et al., 2004, Measurement of halide efflux from cultured and primary airway epithelial cells using fluorescence indicators., J Cyst Fibros, Vol: 3 Suppl 2, Pages: 171-176, ISSN: 1569-1993
The use of the halide-sensitive fluorescent probes (6-methoxy-N-(-sulphopropyl)quinolinium (SPQ) and N-(ethoxycarbonylmethyl)-6-methoxyquinolinium bromide (MQAE)) to measure chloride transport in cells has now been established as an alternative to the halide-selective electrode technique, radioisotope efflux assays and patch-clamp electrophysiology. We report here procedures for the assessment of halide efflux, using SPQ/MQAE halide-sensitive fluorescent indicators, from both adherent cultured epithelial cells and freshly obtained primary human airway epithelial cells. The procedure describes the calculation of efflux rate constants using experimentally derived SPQ/MQAE fluorescence intensities and empirically derived Stern-Volmer calibration constants. These fluorescence methods permit the quantitative analysis of CFTR function.
Radke PW, Heinl-Green A, Frass OM, et al., 2004, Effects of intramyocardial pVEGF<sub>165</sub> delivery on regional myocardial blood flow:: evidence for a spatial 'delivery-efficacy' mismatch, GENE THERAPY, Vol: 11, Pages: 1249-1255, ISSN: 0969-7128
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- Citations: 14
Degabriele NM, Griesenbach U, Sato K, et al., 2004, Critical appraisal of the mouse model of myocardial infarction, EXPERIMENTAL PHYSIOLOGY, Vol: 89, Pages: 497-505, ISSN: 0958-0670
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- Citations: 34
McShane D, Davies JC, Wodehouse T, et al., 2004, Normal nasal mucociliary clearance in CF children: evidence against a CFTR-related defect, EUROPEAN RESPIRATORY JOURNAL, Vol: 24, Pages: 95-100, ISSN: 0903-1936
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- Citations: 31
Griesenbach U, Boyton R, Somerton L, et al., 2004, Tolerisation of mice to allow repeated administration of recombinant Sendai virus vector to the airways, 7th Annual Meeting of the American-Society-of-Gene-Therapy, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: S274-S275, ISSN: 1525-0016
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- Citations: 1
McLachlan G, Griesenbach U, Owaki T, et al., 2004, Recombinant Sendai virus vector to evaluate vector distribution in a large animal model of lung gene transfer, 7th Annual Meeting of the American-Society-of-Gene-Therapy, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: S188-S188, ISSN: 1525-0016
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- Citations: 1
Xenariou S, Griesenbach U, Ferrari S, et al., 2004, Magnetofection to enhance airway gene transfer, 7th Annual Meeting of the American-Society-of-Gene-Therapy, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: S180-S180, ISSN: 1525-0016
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- Citations: 3
Xenariou S, Griesenbach U, Bowden R, et al., 2004, Magnetofection to enhance transfection efficiency of large genomic context vectors <i>in vitro</i>, 7th Annual Meeting of the American-Society-of-Gene-Therapy, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: S182-S182, ISSN: 1525-0016
Griesenbach U, Garcia SE, Kitson C, et al., 2004, Down-regulation of the epithelial sodium channel ENaC through antisense oligonucleotides, 7th Annual Meeting of the American-Society-of-Gene-Therapy, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: S192-S193, ISSN: 1525-0016
Griesenbach U, Dean P, Marshall N, et al., 2004, Magnetofection and ultrasound to increase "naked" DNA delivery to the myocardium, 7th Annual Meeting of the American-Society-of-Gene-Therapy, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: S358-S358, ISSN: 1525-0016
Ban H, Inoue M, Griesenbach U, et al., 2004, Proper maturation of CFTR protein expressed by SeV vector was proved by using a GFP-CFTR fusion protein, 7th Annual Meeting of the American-Society-of-Gene-Therapy, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: S275-S275, ISSN: 1525-0016
Shirohzu H, Mitomo K, Tabata T, et al., 2004, Efficient <i>in vivo</i> transduction of mouse airway epithelial cells by the Simian immunodeficiency virus vector pseudotyped with Sendai virus F and HN proteins, 7th Annual Meeting of the American-Society-of-Gene-Therapy, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: S188-S188, ISSN: 1525-0016
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- Citations: 3
Davies JC, Turner MW, Klein N, et al., 2004, Impaired pulmonary status in cystic fibrosis adults with two mutated MBL-2 alleles, European Respiratory Journal, Vol: 24, Pages: 708-804
Alton EWFW, United Kingdom Cystic Fibrosis Gene Therapy Consortium, 2004, Use of nonviral vectors for cystic fibrosis gene therapy., Proc Am Thorac Soc, Vol: 1, Pages: 296-301, ISSN: 1546-3222
Over the last decade, three groups within the United Kingdom (Edinburgh, Oxford, and Imperial College, London) have undertaken key studies in the development of clinical gene therapy for cystic fibrosis. In 2001, catalyzed by the Cystic Fibrosis Trust, these groups came together to form the United Kingdom Cystic Fibrosis Gene Therapy Consortium. The Consortium has removed duplication and competition, developed core facilities playing to the respective strengths of the centers, and introduced the joint strategy described in this article. This is driven by a clinical trial program, with a product pipeline and the necessary development of novel preclinical and human assays. The program is milestone-related, has a structure that lies between the pharmaceutical industry and academia, and has as its endpoint negotiations with industry to undertake a phase III clinical trial of the identified product.
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