Imperial College London
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DrEszterVamos

Faculty of Medicine, School of Public Health

Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 7457e.vamos

 
 
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Location

 

321Reynolds BuildingCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Vamos:2010:10.2337/dc10-0989,
author = {Vamos, EP and Bottle, A and Edmonds, ME and Valabhji, J and Majeed, A and Millett, C},
doi = {10.2337/dc10-0989},
journal = {Diabetes Care},
pages = {2592--2597},
title = {Changes in the incidence of lower extremity amputations in people with and without diabetes in England between 2004 and 2008},
url = {http://dx.doi.org/10.2337/dc10-0989},
volume = {33},
year = {2010}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE — To describe recent trends in the incidence of nontraumatic amputationsamong individuals with and without diabetes and estimate the relative risk of amputationsamong individuals with diabetes in England.RESEARCH DESIGN AND METHODS — We identified all patients aged  16 yearswho underwent any nontraumatic amputation in England between 2004 and 2008 using nationalhospital activity data from all National Health Service hospitals. Age- and sex-specificincidence rates were calculated using the total diabetes population in England every year. To testfor time trend, we fitted Poisson regression models.RESULTS — The absolute number of diabetes-related amputations increased by 14.7%, andthe incidence decreased by 9.1%, from 27.5 to 25.0 per 10,000 people with diabetes, during thestudy period (P   0.2 for both). The incidence of minor and major amputations did notsignificantly change (15.7–14.9 and 11.8–10.2 per 10,000 people with diabetes; P  0.66 andP  0.29, respectively). Poisson regression analysis showed no statistically significant change indiabetes-related amputation incidence over time (0.98 decrease per year [95% CI 0.93–1.02];P  0.12). Nondiabetes-related amputation incidence decreased from 13.6 to 11.9 per 100,000people without diabetes (0.97 decrease by year [0.93–1.00]; P  0.059). The relative risk of anindividual with diabetes undergoing a lower extremity amputation was 20.3 in 2004 and 21.2 in2008, compared with that of individuals without diabetes.CONCLUSIONS — This national study suggests that the overall population burden of amputationsincreased in people with diabetes at a time when the number and incidence of amputationsdecreased in the aging nondiabetic population.
AU  - Vamos,EP
AU  - Bottle,A
AU  - Edmonds,ME
AU  - Valabhji,J
AU  - Majeed,A
AU  - Millett,C
DO  - 10.2337/dc10-0989
EP  - 2597
PY  - 2010///
SN  - 1935-5548
SP  - 2592
TI  - Changes in the incidence of lower extremity amputations in people with and without diabetes in England between 2004 and 2008
T2  - Diabetes Care
UR  - http://dx.doi.org/10.2337/dc10-0989
UR  - http://hdl.handle.net/10044/1/34258
VL  - 33
ER  -
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