Imperial College London
Portrait Picture

DrFionaWatt

Faculty of Medicine, Department of Immunology and Inflammation

Reader in Rheumatology
 
 
 
//

Contact

 

f.watt

 
 
//

Location

 

Commonwealth BuildingHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Whittaker:2024:10.1016/j.ocarto.2024.100449,
author = {Whittaker, JL and Kalsoum, R and Bilzon, J and Conaghan, PG and Crossley, K and Dodge, GR and Getgood, A and Li, X and Losina, E and Mason, DJ and Pietrosimone, B and Risberg, MA and Roemer, F and Felson, D and Culvenor, A and Meuffels, D and Gerwin, N and Simon, LS and Lohmander, LS and Englund, M and Watt, FE},
doi = {10.1016/j.ocarto.2024.100449},
journal = {Osteoarthritis and Cartilage Open},
title = {Toward designing human intervention studies to prevent osteoarthritis after knee injury: a report from an interdisciplinary OARSI 2023 workshop},
url = {http://dx.doi.org/10.1016/j.ocarto.2024.100449},
volume = {6},
year = {2024}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ObjectiveThe global impact of osteoarthritis is growing. Currently no disease modifying osteoarthritis drugs/therapies exist, increasing the need for preventative strategies. Knee injuries have a high prevalence, distinct onset, and strong independent association with post-traumatic osteoarthritis (PTOA). Numerous groups are embarking upon research that will culminate in clinical trials to assess the effect of interventions to prevent knee PTOA despite challenges and lack of consensus about trial design in this population. Our objectives were to improve awareness of knee PTOA prevention trial design and discuss state-of-the art methods to address the unique opportunities and challenges of these studies.DesignAn international interdisciplinary group developed a workshop, hosted at the 2023 Osteoarthritis Research Society International Congress. Here we summarize the workshop content and outputs, with the goal of moving the field of PTOA prevention trial design forward.ResultsWorkshop highlights included discussions about target population (considering risk, homogeneity, and possibility of modifying osteoarthritis outcome); target treatment (considering delivery, timing, feasibility and effectiveness); comparators (usual care, placebo), and primary symptomatic outcomes considering surrogates and the importance of knee function and symptoms other than pain to this population.ConclusionsOpportunities to test multimodal PTOA prevention interventions across preclinical models and clinical trials exist. As improving symptomatic outcomes aligns with patient and regulator priorities, co-primary symptomatic (single or aggregate/multidimensional outcome considering function and symptoms beyond pain) and structural/physiological outcomes may be appropriate for these trials. To ensure PTOA prevention trials are relevant and acceptable to all stakeholders, future research should address critical knowledge gaps and challenges.
AU  - Whittaker,JL
AU  - Kalsoum,R
AU  - Bilzon,J
AU  - Conaghan,PG
AU  - Crossley,K
AU  - Dodge,GR
AU  - Getgood,A
AU  - Li,X
AU  - Losina,E
AU  - Mason,DJ
AU  - Pietrosimone,B
AU  - Risberg,MA
AU  - Roemer,F
AU  - Felson,D
AU  - Culvenor,A
AU  - Meuffels,D
AU  - Gerwin,N
AU  - Simon,LS
AU  - Lohmander,LS
AU  - Englund,M
AU  - Watt,FE
DO  - 10.1016/j.ocarto.2024.100449
PY  - 2024///
SN  - 2665-9131
TI  - Toward designing human intervention studies to prevent osteoarthritis after knee injury: a report from an interdisciplinary OARSI 2023 workshop
T2  - Osteoarthritis and Cartilage Open
UR  - http://dx.doi.org/10.1016/j.ocarto.2024.100449
UR  - http://hdl.handle.net/10044/1/109953
VL  - 6
ER  -
Download